Studying epigenomic regulation of cell differentiation, with a focus on enhancer regulation by histone modifying or chromatin remodeling enzymes
Select Publications
- MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
- Xie G, Lee JE, Senft AD, Park YK, Jang Y, Chakraborty S, Thompson JJ, McKernan K, Liu C, Macfarlan TS, Rocha PP, Peng W, Ge K.
- Nat Genet (2023 Apr) 55:693-705. Abstract/Full Text
- MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state.
- Cui J, Zhang C, Lee JE, Bartholdy BA, Yang D, Liu Y, Erler P, Galbo PM Jr, Hodge DQ, Huangfu D, Zheng D, Ge K, Guo W.
- Nat Cell Biol (2023 Jan) 25:145-158. Abstract/Full Text
Lab Members
Back left to right: Guojia Xie, Young-Kwon Park, Christabelle Agyapong, Hieu Van. Front left to right: Kai Ge, Cuncun Ke, Danyang Wan, Ji-Eun Lee.
Last Reviewed May 2023