- Ph.D., McGill University, 1999
My laboratory investigates how metabolism and the brain adapt in response to a variety of interventions to diet and physical activity. We perform experiments in both humans and rodents to better understand the complex mechanisms regulating macronutrient metabolism, body composition, and energy expenditure. A unique aspect of our laboratory involves the development of mathematical models to quantitatively describe, explain, integrate, and predict our experimental results.
- Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity.
- Hall KD, Bemis T, Brychta R, Chen KY, Courville A, Crayner EJ, Goodwin S, Guo J, Howard L, Knuth ND, Miller BV 3rd, Prado CM, Siervo M, Skarulis MC, Walter M, Walter PJ, Yannai L.
- Cell Metab (2015 Sep 1) 22:427-36. Abstract/Full Text
- Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior.
- Guo J, Simmons WK, Herscovitch P, Martin A, Hall KD.
- Mol Psychiatry (2014 Oct) 19:1078-84. Abstract/Full Text
Research in Plain Language
My laboratory studies the regulation of body weight and metabolism—the processes through which food is converted into the energy. We perform experiments in both humans and rodents to better understand the complex mechanisms that control
- metabolism of macronutrients—proteins, fats, and carbohydrates;
- food choice and eating behavior;
- body weight and composition; and
- energy expenditure, which is the amount of calories used to maintain life and perform physical work.
A unique aspect of our research group is that we develop mathematical models to describe, explain, integrate, and predict the results of our experiments.
- Mathematical Modeling of Metabolism and Body Weight Regulation
- Research Behind the Body Weight Planner
- NIH Research in Action: The Human Energy Crisis