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Smita Jha, M.D.

Photo of Smita Jha, M.D.
Scientific Focus Areas: Clinical Research, Genetics and Genomics

Professional Experience

  • Director, Calcium & MEN1 Research, Metabolic Diseases Branch, 2020-present
  • Assistant Research Physician, Section on Congenital Disorders, NIH Clinical Center, 2018-2020
  • Faculty, Inter-Institute Endocrinology Training Program, 2016- present
  • Scholar in Translational Research, NIAMS, 2016-2018
  • Endocrinology and Metabolism Fellowship, Inter-Institute Endocrinology Training Program, NICHD, 2013-2016
  • Internal Medicine Residency, North Shore Medical Center, 2009-2012
  • M.D., Bangalore Medical College and Research Institute, 2007

Current Research

Our long-term goal is to enhance the knowledge and ultimately advance the care of patients with parathyroid tumors and parathyroid hormone signaling disorders. The primary disorders of interest include a) parathyroid cancer and atypical parathyroid tumors b) Jansen’s metaphyseal chondrodysplasia c) heritable forms of primary hyperparathyroidism including familial hypocalciuric hypercalcemia, multiple endocrine neoplasia type 1 and d) pseudohypoparathyroidism and related disorders.

Applying our Research

We aim to elucidate the pathophysiology of diseases under study and identify novel biomarkers and treatments.

Select Publications

Blood-based Proteomic Signatures Associated With MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression.
Fahrmann JF, Wasylishen AR, Pieterman CRC, Irajizad E, Vykoukal J, Wu R, Dennison JB, Peterson CB, Zhao H, Do KA, Halperin DM, Agarwal SK, Blau JE, Jha S, Rivero JD, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM, Katayama H.
J Clin Endocrinol Metab (2023 Nov 17) 108:3260-3271. Abstract/Full Text
Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.
Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S.
J Clin Endocrinol Metab (2023 Nov 17) 108:3165-3177. Abstract/Full Text
View More Publications

Research in Plain Language

We study patients with parathyroid cancer or atypical tumors or disorders of parathyroid signaling. Some examples of these disorders are: 

  • parathyroid cancer
  • Jansen’s metaphyseal chondrodysplasia
  • heritable forms of hyperparathyroidism including familial hypocalciuric hypercalcemia, multiple endocrine neoplasia type 1, familial isolated hyperparathyroidism and hyperparathyroid jaw tumor syndrome
  • pseudohypoparathyroidism and related disorders

We wish to identify new predictors which can predict the disease course and identify novel treatments for these disorders.

Last Reviewed November 2023