Smita Jha, M.D.

Associate Research Physician: Signal Transduction Section, Metabolic Diseases Branch

Scientific Focus Areas: Clinical Research, Genetics and Genomics, Cancer Biology, Molecular Biology and Biochemistry

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Publications

A selection of recent and significant publications can be viewed below.

A Germline ZFX Missense Variant in a Patient With Primary Hyperparathyroidism.

Guan B, Agarwal SK, Welch JM, Jha S, Weinstein LS, Simonds WF.

JCEM Case Rep (2024 Aug) 2:luae115. Abstract/Full Text

Ocular findings in Jansen metaphyseal chondrodysplasia.

Obiezu F, Magone De Quadros Costa MT, Huryn LA, Pan K, Almpani K, Ninan A, Roszko KL, Weinstein LS, Gafni RI, Ferreira CR, Lee J, Collins MT, Jha S.

JBMR Plus (2024 Sep) 8:ziae089. Abstract/Full Text

Invasive Testing for Preoperative Localization of Parathyroid Tumors.

Graf A, Cochran C, Sadowski S, Nilubol N, Simonds WF, Weinstein LS, Chang R, Jha S.

J Endocr Soc (2023 Dec 1) 8:bvad158. Abstract/Full Text

Blood-based Proteomic Signatures Associated With MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression.

Fahrmann JF, Wasylishen AR, Pieterman CRC, Irajizad E, Vykoukal J, Wu R, Dennison JB, Peterson CB, Zhao H, Do KA, Halperin DM, Agarwal SK, Blau JE, Jha S, Rivero JD, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM, Katayama H.

J Clin Endocrinol Metab (2023 Nov 17) 108:3260-3271. Abstract/Full Text

Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.

Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S.

J Clin Endocrinol Metab (2023 Nov 17) 108:3165-3177. Abstract/Full Text

Germline- and Somatic-Inactivating FLCN Variants in Parathyroid Cancer and Atypical Parathyroid Tumors.

Jha S, Welch J, Tora R, Lack J, Warner A, Del Rivero J, Sadowski SM, Nilubol N, Schmidt LS, Linehan WM, Weinstein LS, Simonds WF, Agarwal SK.

J Clin Endocrinol Metab (2023 Sep 18) 108:2686-2698. Abstract/Full Text

Micronutrient Supplementation and Bone Health After Prophylactic Total Gastrectomy in Patients With CDH1 Variants.

Gamble LA, Lopez R, Rajasimhan S, Samaranayake SG, Bowden C, Famiglietti AL, Blakely AM, Jha S, Ahlman MA, Davis JL.

J Clin Endocrinol Metab (2023 Sep 18) 108:2635-2642. Abstract/Full Text

Molecular and Clinical Spectrum of Primary Hyperparathyroidism.

Jha S, Simonds WF.

Endocr Rev (2023 Sep 15) 44:779-818. Abstract/Full Text

Case Report: Nine-year-old with parathyroid adenoma within the piriform sinus.

Zenno A, Ramamoorthy B, Hammoud DA, Quezado M, Zeiger MA, Jha S.

Front Endocrinol (Lausanne) (2023) 14:1171052. Abstract/Full Text

Occupational engagement, fatigue, and upper and lower extremity abilities in persons with melorheostosis.

Farrell K, Comis LE, Casimir MM, Hodsdon B, Jiménez-Silva R, Dunigan T, Bhattacharyya T, Jha S.

PM R (2023 May) 15:587-595. Abstract/Full Text

Long-Term Outcomes of Parathyroid Autografts in Primary Hyperparathyroidism.

Chuki E, Graf A, Ninan A, Tora R, Abijo T, Bliss L, Nilubol N, Weinstein LS, Agarwal SK, Simonds WF, Jha S.

J Endocr Soc (2023 Mar 6) 7:bvad055. Abstract/Full Text

Fibroblasts from Patients with Melorheostosis Promote Angiogenesis in Healthy Endothelial Cells through Secreted Factors.

Hurley-Novatny AC, Allbritton-King JD, Jha S, Cowen EW, Colbert RA, Navid F, Bhattacharyya T.

J Invest Dermatol (2022 Sep) 142:2406-2414.e5. Abstract/Full Text

Excess 11-Oxygenated Androgens in Women With Severe Insulin Resistance Are Mediated by Adrenal Insulin Receptor Signaling.

Walzer D, Turcu AF, Jha S, Abel BS, Auchus RJ, Merke DP, Brown RJ.

J Clin Endocrinol Metab (2022 Aug 18) 107:2626-2635. Abstract/Full Text

Metastatic Grade 3 Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Expressing Somatostatin Receptors.

Graf A, Welch J, Bansal R, Mandl A, Parekh VI, Cochran C, Levy E, Nilubol N, Patel D, Sadowski S, Jha S, Agarwal SK, Millo C, Blau JE, Simonds WF, Weinstein LS, Del Rivero J.

J Endocr Soc (2022 Oct 1) 6:bvac122. Abstract/Full Text

Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer.

Afreen S, Weinstein LS, Simonds WF, Jha S.

J Endocr Soc (2022 Aug 1) 6:bvac096. Abstract/Full Text

Cardiovascular Disease Risk Factors and Metabolic Morbidity in a Longitudinal Study of Congenital Adrenal Hyperplasia.

Torky A, Sinaii N, Jha S, Desai J, El-Maouche D, Mallappa A, Merke DP.

J Clin Endocrinol Metab (2021 Nov 19) 106:e5247-e5257. Abstract/Full Text

Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus.

Mandl A, Welch JM, Kapoor G, Parekh VI, Schrump DS, Ripley RT, Walter MF, Del Rivero J, Jha S, Simonds WF, Jensen RT, Weinstein LS, Blau JE, Agarwal SK.

Endocr Relat Cancer (2021 Oct 4) 28:L15-L19. Abstract/Full Text

Distribution and Functional Consequences of Somatic MAP2K1 Variants in Affected Skin Associated with Bone Lesions in Melorheostosis.

Jha S, Ivovic A, Kang H, Meylan F, Hanson EP, Rimland C, Lange E, Katz J, McBride A, Warner AC, Edmondson EF, Cowen EW, Marini JC, Siegel RM, Bhattacharyya T.

J Invest Dermatol (2021 Mar) 141:688-692.e11. Abstract/Full Text

Nonclassic Congenital Adrenal Hyperplasia: What Do Endocrinologists Need to Know?

Jha S, Turcu AF.

Endocrinol Metab Clin North Am (2021 Mar) 50:151-165. Abstract/Full Text

Cross-Sectional Imaging Useful in Melorheostosis.

Hurley-Novatny A, Karantanas AH, Papadakis GZ, Bhattacharyya T, Jha S.

JBMR Plus (2021 Apr) 5:e10472. Abstract/Full Text

11-Oxygenated Androgens Useful in the Setting of Discrepant Conventional Biomarkers in 21-Hydroxylase Deficiency.

Jha S, Turcu AF, Sinaii N, Brookner B, Auchus RJ, Merke DP.

J Endocr Soc (2021 Feb 1) 5:bvaa192. Abstract/Full Text

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway.

Kang H, Jha S, Ivovic A, Fratzl-Zelman N, Deng Z, Mitra A, Cabral WA, Hanson EP, Lange E, Cowen EW, Katz J, Roschger P, Klaushofer K, Dale RK, Siegel RM, Bhattacharyya T, Marini JC.

J Exp Med (2020 May 4) 217. Abstract/Full Text

Remission of hypertension after surgical cure of Cushing's syndrome.

Jha S, Sinaii N, McGlotten RN, Nieman LK.

Clin Endocrinol (Oxf) (2020 Feb) 92:124-130. Abstract/Full Text

Melorheostosis: A Clinical, Pathologic, and Radiologic Case Series.

Fick CN, Fratzl-Zelman N, Roschger P, Klaushofer K, Jha S, Marini JC, Bhattacharyya T.

Am J Surg Pathol (2019 Nov) 43:1554-1559. Abstract/Full Text

Individualizing Management of Infertility in Classic Congenital Adrenal Hyperplasia and Testicular Adrenal Rest Tumors.

Jha S, El-Maouche D, Marko J, Mallappa A, Veeraraghavan P, Merke DP.

J Endocr Soc (2019 Dec 1) 3:2290-2294. Abstract/Full Text

When Low Bone Mineral Density and Fractures Is Not Osteoporosis.

Jha S, Chapman M, Roszko K.

Curr Osteoporos Rep (2019 Oct) 17:324-332. Abstract/Full Text

Clinical Evaluation of Melorheostosis in the Context of a Natural History Clinical Study.

Jha S, Cowen EW, Lehky TJ, Alter K, Flynn L, Reynolds JC, Lange E, Katz JD, Marini JC, Siegel RM, Bhattacharyya T.

JBMR Plus (2019 Aug) 3:e10214. Abstract/Full Text

Melorheostotic Bone Lesions Caused by Somatic Mutations in MAP2K1 Have Deteriorated Microarchitecture and Periosteal Reaction.

Fratzl-Zelman N, Roschger P, Kang H, Jha S, Roschger A, Blouin S, Deng Z, Cabral WA, Ivovic A, Katz J, Siegel RM, Klaushofer K, Fratzl P, Bhattacharyya T, Marini JC.

J Bone Miner Res (2019 May) 34:883-895. Abstract/Full Text

Retrospective study of inpatient diabetes management service, length of stay and 30-day readmission rate of patients with diabetes at a community hospital.

Mandel SR, Langan S, Mathioudakis NN, Sidhaye AR, Bashura H, Bie JY, Mackay P, Tucker C, Demidowich AP, Simonds WF, Jha S, Ebenuwa I, Kantsiper M, Howell EE, Wachter P, Golden SH, Zilbermint M.

J Community Hosp Intern Med Perspect (2019 Apr) 9:64-73. Abstract/Full Text

Distinct Clinical and Pathological Features of Melorheostosis Associated With Somatic MAP2K1 Mutations.

Jha S, Fratzl-Zelman N, Roschger P, Papadakis GZ, Cowen EW, Kang H, Lehky TJ, Alter K, Deng Z, Ivovic A, Flynn L, Reynolds JC, Dasgupta A, Miettinen M, Lange E, Katz J, Klaushofer K, Marini JC, Siegel RM, Bhattacharyya T.

J Bone Miner Res (2019 Jan) 34:145-156. Abstract/Full Text

CT analysis of anatomical distribution of melorheostosis challenges the sclerotome hypothesis.

Jha S, Laucis N, Kim L, Malayeri A, Dasgupta A, Papadakis GZ, Karantanas A, Torres M, Bhattacharyya T.

Bone (2018 Dec) 117:31-36. Abstract/Full Text

Diverticular Perforation: A Fatal Complication to Forestall in Cushing Syndrome.

Sater ZA, Jha S, McGlotten R, Hartley I, El Lakis M, Araque KA, Nieman LK.

J Clin Endocrinol Metab (2018 Aug 1) 103:2811-2814. Abstract/Full Text

Somatic activating mutations in MAP2K1 cause melorheostosis.

Kang H, Jha S, Deng Z, Fratzl-Zelman N, Cabral WA, Ivovic A, Meylan F, Hanson EP, Lange E, Katz J, Roschger P, Klaushofer K, Cowen EW, Siegel RM, Marini JC, Bhattacharyya T.

Nat Commun (2018 Apr 11) 9:1390. Abstract/Full Text

18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement.

Papadakis GZ, Jha S, Bhattacharyya T, Millo C, Tu TW, Bagci U, Marias K, Karantanas AH, Patronas NJ.

Clin Nucl Med (2017 Jul) 42:537-539. Abstract/Full Text

Utilization and cost of anti-osteoporosis therapy among US Medicare beneficiaries.

Jha S, Bhattacharyya T.

Arch Osteoporos (2016 Dec) 11:28. Abstract/Full Text

Normal and Delayed Fracture Healing: Symphony and Cacophony.

Jha S, Blau JE, Bhattacharyya T.

Horm Metab Res (2016 Nov) 48:779-784. Abstract/Full Text

Hypophosphatasia and the risk of atypical femur fractures: a case-control study.

Bhattacharyya T, Jha S, Wang H, Kastner DL, Remmers EF.

BMC Musculoskelet Disord (2016 Aug 9) 17:332. Abstract/Full Text

Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996-2012: An Ecological Analysis.

Jha S, Wang Z, Laucis N, Bhattacharyya T.

J Bone Miner Res (2015 Dec) 30:2179-87. Abstract/Full Text

HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature.

Saini N, Hochberg EP, Linden EA, Jha S, Grohs HK, Sohani AR.

Case Rep Oncol Med (2013) 2013:292301. Abstract/Full Text

The perils of not digging deep enough--uncovering a rare cause of acquired anemia.

Saini N, Jacobson JO, Jha S, Saini V, Weinger R.

Am J Hematol (2012 Apr) 87:413-6. Abstract/Full Text

Hyperuricemic renal failure in nonhematologic solid tumors: a case report and review of the literature.

Saini N, Pyo Lee K, Jha S, Patel S, Bonthu N, Kansagra A, Bhatia A, Martinez SE, Patel J, Altamimi S, Ghotb S.

Case Rep Med (2012) 2012:314056. Abstract/Full Text