Smita Jha, M.D.
![Smita Jha.](/-/media/Images/About-NIDDK/Profile-Images/Profile-Images---Intramural/jha-smita_120x180.jpg?h=180&iar=0&w=120&hash=4850BEEBDB9E7C655B7AFE0950A9E7E2)
Associate Research Physician:
Signal Transduction Section, Metabolic Diseases Branch
Scientific Focus Areas: Clinical Research, Genetics and Genomics, Cancer Biology, Molecular Biology and Biochemistry
Publications
A selection of recent and significant publications can be viewed below.
- Blood-based Proteomic Signatures Associated With MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression.
- Fahrmann JF, Wasylishen AR, Pieterman CRC, Irajizad E, Vykoukal J, Wu R, Dennison JB, Peterson CB, Zhao H, Do KA, Halperin DM, Agarwal SK, Blau JE, Jha S, Rivero JD, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM, Katayama H.
- J Clin Endocrinol Metab (2023 Nov 17) 108:3260-3271. Abstract/Full Text
- Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.
- Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S.
- J Clin Endocrinol Metab (2023 Nov 17) 108:3165-3177. Abstract/Full Text
- Germline- and Somatic-Inactivating FLCN Variants in Parathyroid Cancer and Atypical Parathyroid Tumors.
- Jha S, Welch J, Tora R, Lack J, Warner A, Del Rivero J, Sadowski SM, Nilubol N, Schmidt LS, Linehan WM, Weinstein LS, Simonds WF, Agarwal SK.
- J Clin Endocrinol Metab (2023 Sep 18) 108:2686-2698. Abstract/Full Text
- Micronutrient Supplementation and Bone Health After Prophylactic Total Gastrectomy in Patients With CDH1 Variants.
- Gamble LA, Lopez R, Rajasimhan S, Samaranayake SG, Bowden C, Famiglietti AL, Blakely AM, Jha S, Ahlman MA, Davis JL.
- J Clin Endocrinol Metab (2023 Sep 18) 108:2635-2642. Abstract/Full Text
- Molecular and Clinical Spectrum of Primary Hyperparathyroidism.
- Jha S, Simonds WF.
- Endocr Rev (2023 Sep 15) 44:779-818. Abstract/Full Text
- Case Report: Nine-year-old with parathyroid adenoma within the piriform sinus.
- Zenno A, Ramamoorthy B, Hammoud DA, Quezado M, Zeiger MA, Jha S.
- Front Endocrinol (Lausanne) (2023) 14:1171052. Abstract/Full Text
- Occupational engagement, fatigue, and upper and lower extremity abilities in persons with melorheostosis.
- Farrell K, Comis LE, Casimir MM, Hodsdon B, Jiménez-Silva R, Dunigan T, Bhattacharyya T, Jha S.
- PM R (2023 May) 15:587-595. Abstract/Full Text
- Long-Term Outcomes of Parathyroid Autografts in Primary Hyperparathyroidism.
- Chuki E, Graf A, Ninan A, Tora R, Abijo T, Bliss L, Nilubol N, Weinstein LS, Agarwal SK, Simonds WF, Jha S.
- J Endocr Soc (2023 Mar 6) 7:bvad055. Abstract/Full Text
- Fibroblasts from Patients with Melorheostosis Promote Angiogenesis in Healthy Endothelial Cells through Secreted Factors.
- Hurley-Novatny AC, Allbritton-King JD, Jha S, Cowen EW, Colbert RA, Navid F, Bhattacharyya T.
- J Invest Dermatol (2022 Sep) 142:2406-2414.e5. Abstract/Full Text
- Excess 11-Oxygenated Androgens in Women With Severe Insulin Resistance Are Mediated by Adrenal Insulin Receptor Signaling.
- Walzer D, Turcu AF, Jha S, Abel BS, Auchus RJ, Merke DP, Brown RJ.
- J Clin Endocrinol Metab (2022 Aug 18) 107:2626-2635. Abstract/Full Text
- Metastatic Grade 3 Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Expressing Somatostatin Receptors.
- Graf A, Welch J, Bansal R, Mandl A, Parekh VI, Cochran C, Levy E, Nilubol N, Patel D, Sadowski S, Jha S, Agarwal SK, Millo C, Blau JE, Simonds WF, Weinstein LS, Del Rivero J.
- J Endocr Soc (2022 Oct 1) 6:bvac122. Abstract/Full Text
- Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer.
- Afreen S, Weinstein LS, Simonds WF, Jha S.
- J Endocr Soc (2022 Aug 1) 6:bvac096. Abstract/Full Text
- Cardiovascular Disease Risk Factors and Metabolic Morbidity in a Longitudinal Study of Congenital Adrenal Hyperplasia.
- Torky A, Sinaii N, Jha S, Desai J, El-Maouche D, Mallappa A, Merke DP.
- J Clin Endocrinol Metab (2021 Nov 19) 106:e5247-e5257. Abstract/Full Text
- Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus.
- Mandl A, Welch JM, Kapoor G, Parekh VI, Schrump DS, Ripley RT, Walter MF, Del Rivero J, Jha S, Simonds WF, Jensen RT, Weinstein LS, Blau JE, Agarwal SK.
- Endocr Relat Cancer (2021 Oct 4) 28:L15-L19. Abstract/Full Text
- Distribution and Functional Consequences of Somatic MAP2K1 Variants in Affected Skin Associated with Bone Lesions in Melorheostosis.
- Jha S, Ivovic A, Kang H, Meylan F, Hanson EP, Rimland C, Lange E, Katz J, McBride A, Warner AC, Edmondson EF, Cowen EW, Marini JC, Siegel RM, Bhattacharyya T.
- J Invest Dermatol (2021 Mar) 141:688-692.e11. Abstract/Full Text
- Nonclassic Congenital Adrenal Hyperplasia: What Do Endocrinologists Need to Know?
- Jha S, Turcu AF.
- Endocrinol Metab Clin North Am (2021 Mar) 50:151-165. Abstract/Full Text
- Cross-Sectional Imaging Useful in Melorheostosis.
- Hurley-Novatny A, Karantanas AH, Papadakis GZ, Bhattacharyya T, Jha S.
- JBMR Plus (2021 Apr) 5:e10472. Abstract/Full Text
- 11-Oxygenated Androgens Useful in the Setting of Discrepant Conventional Biomarkers in 21-Hydroxylase Deficiency.
- Jha S, Turcu AF, Sinaii N, Brookner B, Auchus RJ, Merke DP.
- J Endocr Soc (2021 Feb 1) 5:bvaa192. Abstract/Full Text
- Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway.
- Kang H, Jha S, Ivovic A, Fratzl-Zelman N, Deng Z, Mitra A, Cabral WA, Hanson EP, Lange E, Cowen EW, Katz J, Roschger P, Klaushofer K, Dale RK, Siegel RM, Bhattacharyya T, Marini JC.
- J Exp Med (2020 May 4) 217. Abstract/Full Text
- Remission of hypertension after surgical cure of Cushing's syndrome.
- Jha S, Sinaii N, McGlotten RN, Nieman LK.
- Clin Endocrinol (Oxf) (2020 Feb) 92:124-130. Abstract/Full Text
- Melorheostosis: A Clinical, Pathologic, and Radiologic Case Series.
- Fick CN, Fratzl-Zelman N, Roschger P, Klaushofer K, Jha S, Marini JC, Bhattacharyya T.
- Am J Surg Pathol (2019 Nov) 43:1554-1559. Abstract/Full Text
- Individualizing Management of Infertility in Classic Congenital Adrenal Hyperplasia and Testicular Adrenal Rest Tumors.
- Jha S, El-Maouche D, Marko J, Mallappa A, Veeraraghavan P, Merke DP.
- J Endocr Soc (2019 Dec 1) 3:2290-2294. Abstract/Full Text
- When Low Bone Mineral Density and Fractures Is Not Osteoporosis.
- Jha S, Chapman M, Roszko K.
- Curr Osteoporos Rep (2019 Oct) 17:324-332. Abstract/Full Text
- Clinical Evaluation of Melorheostosis in the Context of a Natural History Clinical Study.
- Jha S, Cowen EW, Lehky TJ, Alter K, Flynn L, Reynolds JC, Lange E, Katz JD, Marini JC, Siegel RM, Bhattacharyya T.
- JBMR Plus (2019 Aug) 3:e10214. Abstract/Full Text
- Melorheostotic Bone Lesions Caused by Somatic Mutations in MAP2K1 Have Deteriorated Microarchitecture and Periosteal Reaction.
- Fratzl-Zelman N, Roschger P, Kang H, Jha S, Roschger A, Blouin S, Deng Z, Cabral WA, Ivovic A, Katz J, Siegel RM, Klaushofer K, Fratzl P, Bhattacharyya T, Marini JC.
- J Bone Miner Res (2019 May) 34:883-895. Abstract/Full Text
- Retrospective study of inpatient diabetes management service, length of stay and 30-day readmission rate of patients with diabetes at a community hospital.
- Mandel SR, Langan S, Mathioudakis NN, Sidhaye AR, Bashura H, Bie JY, Mackay P, Tucker C, Demidowich AP, Simonds WF, Jha S, Ebenuwa I, Kantsiper M, Howell EE, Wachter P, Golden SH, Zilbermint M.
- J Community Hosp Intern Med Perspect (2019 Apr) 9:64-73. Abstract/Full Text
- Distinct Clinical and Pathological Features of Melorheostosis Associated With Somatic MAP2K1 Mutations.
- Jha S, Fratzl-Zelman N, Roschger P, Papadakis GZ, Cowen EW, Kang H, Lehky TJ, Alter K, Deng Z, Ivovic A, Flynn L, Reynolds JC, Dasgupta A, Miettinen M, Lange E, Katz J, Klaushofer K, Marini JC, Siegel RM, Bhattacharyya T.
- J Bone Miner Res (2019 Jan) 34:145-156. Abstract/Full Text
- CT analysis of anatomical distribution of melorheostosis challenges the sclerotome hypothesis.
- Jha S, Laucis N, Kim L, Malayeri A, Dasgupta A, Papadakis GZ, Karantanas A, Torres M, Bhattacharyya T.
- Bone (2018 Dec) 117:31-36. Abstract/Full Text
- Diverticular Perforation: A Fatal Complication to Forestall in Cushing Syndrome.
- Sater ZA, Jha S, McGlotten R, Hartley I, El Lakis M, Araque KA, Nieman LK.
- J Clin Endocrinol Metab (2018 Aug 1) 103:2811-2814. Abstract/Full Text
- Somatic activating mutations in MAP2K1 cause melorheostosis.
- Kang H, Jha S, Deng Z, Fratzl-Zelman N, Cabral WA, Ivovic A, Meylan F, Hanson EP, Lange E, Katz J, Roschger P, Klaushofer K, Cowen EW, Siegel RM, Marini JC, Bhattacharyya T.
- Nat Commun (2018 Apr 11) 9:1390. Abstract/Full Text
- 18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement.
- Papadakis GZ, Jha S, Bhattacharyya T, Millo C, Tu TW, Bagci U, Marias K, Karantanas AH, Patronas NJ.
- Clin Nucl Med (2017 Jul) 42:537-539. Abstract/Full Text
- Utilization and cost of anti-osteoporosis therapy among US Medicare beneficiaries.
- Jha S, Bhattacharyya T.
- Arch Osteoporos (2016 Dec) 11:28. Abstract/Full Text
- Normal and Delayed Fracture Healing: Symphony and Cacophony.
- Jha S, Blau JE, Bhattacharyya T.
- Horm Metab Res (2016 Nov) 48:779-784. Abstract/Full Text
- Hypophosphatasia and the risk of atypical femur fractures: a case-control study.
- Bhattacharyya T, Jha S, Wang H, Kastner DL, Remmers EF.
- BMC Musculoskelet Disord (2016 Aug 9) 17:332. Abstract/Full Text
- Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996-2012: An Ecological Analysis.
- Jha S, Wang Z, Laucis N, Bhattacharyya T.
- J Bone Miner Res (2015 Dec) 30:2179-87. Abstract/Full Text
- HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature.
- Saini N, Hochberg EP, Linden EA, Jha S, Grohs HK, Sohani AR.
- Case Rep Oncol Med (2013) 2013:292301. Abstract/Full Text
- The perils of not digging deep enough--uncovering a rare cause of acquired anemia.
- Saini N, Jacobson JO, Jha S, Saini V, Weinger R.
- Am J Hematol (2012 Apr) 87:413-6. Abstract/Full Text
- Hyperuricemic renal failure in nonhematologic solid tumors: a case report and review of the literature.
- Saini N, Pyo Lee K, Jha S, Patel S, Bonthu N, Kansagra A, Bhatia A, Martinez SE, Patel J, Altamimi S, Ghotb S.
- Case Rep Med (2012) 2012:314056. Abstract/Full Text
Last Reviewed November 2023