Smita Jha, M.D.
Photo of Smita Jha, M.D.
Scientific Focus Areas: Clinical Research, Genetics and Genomics


A selection of recent and significant publications can be viewed below.

Distribution and Functional Consequences of Somatic MAP2K1 Variants in Affected Skin Associated with Bone Lesions in Melorheostosis.
Jha S, Ivovic A, Kang H, Meylan F, Hanson EP, Rimland C, Lange E, Katz J, McBride A, Warner AC, Edmondson EF, Cowen EW, Marini JC, Siegel RM, Bhattacharyya T.
J Invest Dermatol (2021 Mar) 141:688-692.e11. Abstract/Full Text
Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway.
Kang H, Jha S, Ivovic A, Fratzl-Zelman N, Deng Z, Mitra A, Cabral WA, Hanson EP, Lange E, Cowen EW, Katz J, Roschger P, Klaushofer K, Dale RK, Siegel RM, Bhattacharyya T, Marini JC.
J Exp Med (2020 May 4) 217. Abstract/Full Text
Remission of hypertension after surgical cure of Cushing's syndrome.
Jha S, Sinaii N, McGlotten RN, Nieman LK.
Clin Endocrinol (Oxf) (2020 Feb) 92:124-130. Abstract/Full Text
Melorheostosis: A Clinical, Pathologic, and Radiologic Case Series.
Fick CN, Fratzl-Zelman N, Roschger P, Klaushofer K, Jha S, Marini JC, Bhattacharyya T.
Am J Surg Pathol (2019 Nov) 43:1554-1559. Abstract/Full Text
Individualizing Management of Infertility in Classic Congenital Adrenal Hyperplasia and Testicular Adrenal Rest Tumors.
Jha S, El-Maouche D, Marko J, Mallappa A, Veeraraghavan P, Merke DP.
J Endocr Soc (2019 Dec 1) 3:2290-2294. Abstract/Full Text
When Low Bone Mineral Density and Fractures Is Not Osteoporosis.
Jha S, Chapman M, Roszko K.
Curr Osteoporos Rep (2019 Oct) 17:324-332. Abstract/Full Text
Clinical Evaluation of Melorheostosis in the Context of a Natural History Clinical Study.
Jha S, Cowen EW, Lehky TJ, Alter K, Flynn L, Reynolds JC, Lange E, Katz JD, Marini JC, Siegel RM, Bhattacharyya T.
JBMR Plus (2019 Aug) 3:e10214. Abstract/Full Text
Melorheostotic Bone Lesions Caused by Somatic Mutations in MAP2K1 Have Deteriorated Microarchitecture and Periosteal Reaction.
Fratzl-Zelman N, Roschger P, Kang H, Jha S, Roschger A, Blouin S, Deng Z, Cabral WA, Ivovic A, Katz J, Siegel RM, Klaushofer K, Fratzl P, Bhattacharyya T, Marini JC.
J Bone Miner Res (2019 May) 34:883-895. Abstract/Full Text
Retrospective study of inpatient diabetes management service, length of stay and 30-day readmission rate of patients with diabetes at a community hospital.
Mandel SR, Langan S, Mathioudakis NN, Sidhaye AR, Bashura H, Bie JY, Mackay P, Tucker C, Demidowich AP, Simonds WF, Jha S, Ebenuwa I, Kantsiper M, Howell EE, Wachter P, Golden SH, Zilbermint M.
J Community Hosp Intern Med Perspect (2019 Apr) 9:64-73. Abstract/Full Text
Distinct Clinical and Pathological Features of Melorheostosis Associated With Somatic MAP2K1 Mutations.
Jha S, Fratzl-Zelman N, Roschger P, Papadakis GZ, Cowen EW, Kang H, Lehky TJ, Alter K, Deng Z, Ivovic A, Flynn L, Reynolds JC, Dasgupta A, Miettinen M, Lange E, Katz J, Klaushofer K, Marini JC, Siegel RM, Bhattacharyya T.
J Bone Miner Res (2019 Jan) 34:145-156. Abstract/Full Text
CT analysis of anatomical distribution of melorheostosis challenges the sclerotome hypothesis.
Jha S, Laucis N, Kim L, Malayeri A, Dasgupta A, Papadakis GZ, Karantanas A, Torres M, Bhattacharyya T.
Bone (2018 Dec) 117:31-36. Abstract/Full Text
Diverticular Perforation: A Fatal Complication to Forestall in Cushing Syndrome.
Sater ZA, Jha S, McGlotten R, Hartley I, El Lakis M, Araque KA, Nieman LK.
J Clin Endocrinol Metab (2018 Aug 1) 103:2811-2814. Abstract/Full Text
Somatic activating mutations in MAP2K1 cause melorheostosis.
Kang H, Jha S, Deng Z, Fratzl-Zelman N, Cabral WA, Ivovic A, Meylan F, Hanson EP, Lange E, Katz J, Roschger P, Klaushofer K, Cowen EW, Siegel RM, Marini JC, Bhattacharyya T.
Nat Commun (2018 Apr 11) 9:1390. Abstract/Full Text
18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement.
Papadakis GZ, Jha S, Bhattacharyya T, Millo C, Tu TW, Bagci U, Marias K, Karantanas AH, Patronas NJ.
Clin Nucl Med (2017 Jul) 42:537-539. Abstract/Full Text
Utilization and cost of anti-osteoporosis therapy among US Medicare beneficiaries.
Jha S, Bhattacharyya T.
Arch Osteoporos (2016 Dec) 11:28. Abstract/Full Text
Normal and Delayed Fracture Healing: Symphony and Cacophony.
Jha S, Blau JE, Bhattacharyya T.
Horm Metab Res (2016 Nov) 48:779-784. Abstract/Full Text
Hypophosphatasia and the risk of atypical femur fractures: a case-control study.
Bhattacharyya T, Jha S, Wang H, Kastner DL, Remmers EF.
BMC Musculoskelet Disord (2016 Aug 9) 17:332. Abstract/Full Text
Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996-2012: An Ecological Analysis.
Jha S, Wang Z, Laucis N, Bhattacharyya T.
J Bone Miner Res (2015 Dec) 30:2179-87. Abstract/Full Text
HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature.
Saini N, Hochberg EP, Linden EA, Jha S, Grohs HK, Sohani AR.
Case Rep Oncol Med (2013) 2013:292301. Abstract/Full Text
The perils of not digging deep enough--uncovering a rare cause of acquired anemia.
Saini N, Jacobson JO, Jha S, Saini V, Weinger R.
Am J Hematol (2012 Apr) 87:413-6. Abstract/Full Text
Hyperuricemic renal failure in nonhematologic solid tumors: a case report and review of the literature.
Saini N, Pyo Lee K, Jha S, Patel S, Bonthu N, Kansagra A, Bhatia A, Martinez SE, Patel J, Altamimi S, Ghotb S.
Case Rep Med (2012) 2012:314056. Abstract/Full Text