T. Jake Liang, M.D., NIH Distinguished Investigator
Photo of Jake Liang
Scientific Focus Areas: Virology, Genetics and Genomics, Cancer Biology, Stem Cell Biology, Clinical Research


A selection of recent and significant publications can be viewed below.

Select Publications

Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly.
Li Q, Pène V, Krishnamurthy S, Cha H, Liang TJ.
Nat Med (2013 Jun) 19:722-9. Abstract/Full Text
Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model.
Carpentier A, Tesfaye A, Chu V, Nimgaonkar I, Zhang F, Lee SB, Thorgeirsson SS, Feinstone SM, Liang TJ.
J Clin Invest (2014 Nov) 124:4953-64. Abstract/Full Text
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ, Liang TJ.
Sci Transl Med (2015 Apr 8) 7:282ra49. Abstract/Full Text
Cellular microRNA networks regulate host dependency of hepatitis C virus infection.
Li Q, Lowey B, Sodroski C, Krishnamurthy S, Alao H, Cha H, Chiu S, El-Diwany R, Ghany MG, Liang TJ.
Nat Commun (2017 Nov 27) 8:1789. Abstract/Full Text
Current and future therapies for hepatitis C virus infection.
Liang TJ, Ghany MG.
N Engl J Med (2013 May 16) 368:1907-17. Abstract/Full Text

Additional Publications

TM6SF2 Promotes Lipidation and Secretion of Hepatitis C Virus in Infected Hepatocytes.
Boyer A, Park SB, de Boer YS, Li Q, Liang TJ.
Gastroenterology (2018 Dec) 155:1923-1935.e8. Abstract/Full Text
Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.
Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang TJ.
J Virol (2018 Oct 1) 92. Abstract/Full Text
Spleen and Liver Volumetrics as Surrogate Markers of Hepatic Venous Pressure Gradient in Patients With Noncirrhotic Portal Hypertension.
Etzion O, Takyar V, Novack V, Gharib AM, Canales R, Adebogun A, Matsumoto E, Eccleston JL, Kleiner DE, Rosenzweig SD, Gunay-Aygun M, Uzel G, Fuss I, Childs R, Holland SM, Levy EB, Liang TJ, Heller T, Koh C.
Hepatol Commun (2018 Aug) 2:919-928. Abstract/Full Text
Hepatitis C in Injection-Drug Users - A Hidden Danger of the Opioid Epidemic.
Liang TJ, Ward JW.
N Engl J Med (2018 Mar 29) 378:1169-1171. Abstract/Full Text
N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly.
Schweitzer CJ, Zhang F, Boyer A, Valdez K, Cam M, Liang TJ.
J Virol (2018 Jan 15) 92. Abstract/Full Text
Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.
Cheng X, Xia Y, Serti E, Block PD, Chung M, Chayama K, Rehermann B, Liang TJ.
Hepatology (2017 Dec) 66:1779-1793. Abstract/Full Text
Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation.
Bolte FJ, O'Keefe AC, Webb LM, Serti E, Rivera E, Liang TJ, Ghany M, Rehermann B.
Gastroenterology (2017 Nov) 153:1392-1403.e2. Abstract/Full Text
Adult-onset cystic fibrosis liver disease: Diagnosis and characterization of an underappreciated entity.
Koh C, Sakiani S, Surana P, Zhao X, Eccleston J, Kleiner DE, Herion D, Liang TJ, Hoofnagle JH, Chernick M, Heller T.
Hepatology (2017 Aug) 66:591-601. Abstract/Full Text
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.
He S, Li K, Lin B, Hu Z, Xiao J, Hu X, Wang AQ, Xu X, Ferrer M, Southall N, Zheng W, Aubé J, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.
J Med Chem (2017 Jul 27) 60:6364-6383. Abstract/Full Text
Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.
Loomba R, Liang TJ.
Gastroenterology (2017 May) 152:1297-1309. Abstract/Full Text
Rapid decrease in hepatitis C viremia by direct acting antivirals improves the natural killer cell response to IFNα.
Serti E, Park H, Keane M, O'Keefe AC, Rivera E, Liang TJ, Ghany M, Rehermann B.
Gut (2017 Apr) 66:724-735. Abstract/Full Text
Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.
Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ.
J Hepatol (2017 Mar) 66:494-503. Abstract/Full Text
Complications of percutaneous liver biopsy with Klatskin needles: a 36-year single-centre experience.
Takyar V, Etzion O, Heller T, Kleiner DE, Rotman Y, Ghany MG, Fryzek N, Williams VH, Rivera E, Auh S, Liang TJ, Hoofnagle JH, Koh C.
Aliment Pharmacol Ther (2017 Mar) 45:744-753. Abstract/Full Text
Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers.
Hong SG, Yada RC, Choi K, Carpentier A, Liang TJ, Merling RK, Sweeney CL, Malech HL, Jung M, Corat MAF, AlJanahi AA, Lin Y, Liu H, Tunc I, Wang X, Palisoc M, Pittaluga S, Boehm M, Winkler T, Zou J, Dunbar CE.
Mol Ther (2017 Jan 4) 25:44-53. Abstract/Full Text
Infection of Hepatocytes With HCV Increases Cell Surface Levels of Heparan Sulfate Proteoglycans, Uptake of Cholesterol and Lipoprotein, and Virus Entry by Up-regulating SMAD6 and SMAD7.
Zhang F, Sodroski C, Cha H, Li Q, Liang TJ.
Gastroenterology (2017 Jan) 152:257-270.e7. Abstract/Full Text
Noninvasive markers for staging fibrosis in chronic delta hepatitis.
Takyar V, Surana P, Kleiner DE, Wilkins K, Hoofnagle JH, Liang TJ, Heller T, Koh C.
Aliment Pharmacol Ther (2017 Jan) 45:127-138. Abstract/Full Text
Hepatitis C Virus: From Obscurity to the Lasker.
Liang TJ.
Gastroenterology (2016 Dec) 151:1052-1053. Abstract/Full Text
Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition.
Li Q, Sodroski C, Lowey B, Schweitzer CJ, Cha H, Zhang F, Liang TJ.
Proc Natl Acad Sci U S A (2016 Jul 5) 113:7620-5. Abstract/Full Text
Experimental models of hepatitis B and C - new insights and progress.
Thomas E, Liang TJ.
Nat Rev Gastroenterol Hepatol (2016 Jun) 13:362-74. Abstract/Full Text
Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen.
Carpentier A, Nimgaonkar I, Chu V, Xia Y, Hu Z, Liang TJ.
Stem Cell Res (2016 May) 16:640-50. Abstract/Full Text
Virology: The X-Files of hepatitis B.
Liang TJ.
Nature (2016 Mar 17) 531:313-4. Abstract/Full Text
Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ.
J Med Chem (2016 Feb 11) 59:841-53. Abstract/Full Text
Evaluation of antiviral drug synergy in an infectious HCV system.
Lin B, He S, Yim HJ, Liang TJ, Hu Z.
Antivir Ther (2016) 21:595-603. Abstract/Full Text
Present and future therapies of hepatitis B: From discovery to cure.
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS.
Hepatology (2015 Dec) 62:1893-908. Abstract/Full Text
Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.
Hu Z, Hu X, He S, Yim HJ, Xiao J, Swaroop M, Tanega C, Zhang YQ, Yi G, Kao CC, Marugan J, Ferrer M, Zheng W, Southall N, Liang TJ.
Antiviral Res (2015 Dec) 124:20-9. Abstract/Full Text
Hepatitis C virus treatment in the real world: optimising treatment and access to therapies.
Zoulim F, Liang TJ, Gerbes AL, Aghemo A, Deuffic-Burban S, Dusheiko G, Fried MW, Pol S, Rockstroh JK, Terrault NA, Wiktor S.
Gut (2015 Nov) 64:1824-33. Abstract/Full Text
High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.
He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.
ACS Comb Sci (2015 Oct 12) 17:641-52. Abstract/Full Text
Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function.
Serti E, Chepa-Lotrea X, Kim YJ, Keane M, Fryzek N, Liang TJ, Ghany M, Rehermann B.
Gastroenterology (2015 Jul) 149:190-200.e2. Abstract/Full Text
Hepatic expression levels of interferons and interferon-stimulated genes in patients with chronic hepatitis C: A phenotype-genotype correlation study.
Noureddin M, Rotman Y, Zhang F, Park H, Rehermann B, Thomas E, Liang TJ.
Genes Immun (2015 Jul-Aug) 16:321-9. Abstract/Full Text
Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection.
Pène V, Li Q, Sodroski C, Hsu CS, Liang TJ.
J Virol (2015 May) 89:5462-77. Abstract/Full Text
Durability of antibody response against hepatitis B virus in healthcare workers vaccinated as adults.
Gara N, Abdalla A, Rivera E, Zhao X, Werner JM, Liang TJ, Hoofnagle JH, Rehermann B, Ghany MG.
Clin Infect Dis (2015 Feb 15) 60:505-13. Abstract/Full Text
Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection.
Lepiller Q, Soulier E, Li Q, Lambotin M, Barths J, Fuchs D, Stoll-Keller F, Liang TJ, Barth H.
J Innate Immun (2015) 7:530-44. Abstract/Full Text
Validation of source biasing method for its use in CSNS beamline shielding calculation.
Liang TR, Shen F, Liang TJ, Yin W, Yu QZ, Yu CX.
Radiat Prot Dosimetry (2014 Dec) 162:208-14. Abstract/Full Text
Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling.
Guedj J, Rotman Y, Cotler SJ, Koh C, Schmid P, Albrecht J, Haynes-Williams V, Liang TJ, Hoofnagle JH, Heller T, Dahari H.
Hepatology (2014 Dec) 60:1902-10. Abstract/Full Text
Building bridges and providing transparency to the hepatitis C virus drug approval process.
Ghany MG, Liang TJ.
Gastroenterology (2014 Dec) 147:1201-3. Abstract/Full Text
Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection.
Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B.
Hepatology (2014 Oct) 60:1160-9. Abstract/Full Text
Long-term therapy of chronic delta hepatitis with peginterferon alfa.
Heller T, Rotman Y, Koh C, Clark S, Haynes-Williams V, Chang R, McBurney R, Schmid P, Albrecht J, Kleiner DE, Ghany MG, Liang TJ, Hoofnagle JH.
Aliment Pharmacol Ther (2014 Jul) 40:93-104. Abstract/Full Text
Therapy of hepatitis C--back to the future.
Liang TJ, Ghany MG.
N Engl J Med (2014 May 22) 370:2043-7. Abstract/Full Text
Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle.
Li Q, Zhang YY, Chiu S, Hu Z, Lan KH, Cha H, Sodroski C, Zhang F, Hsu CS, Thomas E, Liang TJ.
PLoS Pathog (2014 May) 10:e1004163. Abstract/Full Text
Single strain isolation method for cell culture-adapted hepatitis C virus by end-point dilution and infection.
Sugiyama N, Murayama A, Suzuki R, Watanabe N, Shiina M, Liang TJ, Wakita T, Kato T.
PLoS One (2014) 9:e98168. Abstract/Full Text
What is the future of ribavirin therapy for hepatitis C?
Koh C, Liang TJ.
Antiviral Res (2014 Apr) 104:34-9. Abstract/Full Text
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U.
Science (2014 Mar 14) 343:1221-8. Abstract/Full Text
Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection.
Brownell J, Bruckner J, Wagoner J, Thomas E, Loo YM, Gale M Jr, Liang TJ, Polyak SJ.
J Virol (2014 Feb) 88:1582-90. Abstract/Full Text
Sequence analysis of hepatitis C virus from patients with relapse after a sustained virological response: relapse or reinfection?
Hara K, Rivera MM, Koh C, Demino M, Page S, Nagabhyru PR, Rehermann B, Liang TJ, Hoofnagle JH, Heller T.
J Infect Dis (2014 Jan 1) 209:38-45. Abstract/Full Text
Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds.
Hu Z, Lan KH, He S, Swaroop M, Hu X, Southall N, Zheng W, Liang TJ.
Antimicrob Agents Chemother (2014) 58:995-1004. Abstract/Full Text