Publications

A selection of recent and significant publications can be viewed below.

Influence of Nonspecific Interactions on Protein Associations: Implications for Biochemistry In Vivo.: Rivas G, Minton AP.; Annu Rev Biochem (2022 Jun 21) 91:321-351. Abstract/Full Text
Implications of excluded volume for chemical inhibition of protein fibrillation.: Minton AP.; Biochim Biophys Acta Gen Subj (2020 Dec) 1864:129704. Abstract/Full Text
Water Loss in Aging Erythrocytes Provides a Clue to a General Mechanism of Cellular Senescence.: Minton AP.; Biophys J (2020 Nov 17) 119:2039-2044. Abstract/Full Text
Simple Calculation of Phase Diagrams for Liquid-Liquid Phase Separation in Solutions of Two Macromolecular Solute Species.: Minton AP.; J Phys Chem B (2020 Mar 26) 124:2363-2370. Abstract/Full Text
The Cumulative Effect of Surface Adsorption and Excluded Volume in 2D and 3D on Protein Fibrillation.: Minton AP.; Biophys J (2019 Nov 5) 117:1666-1673. Abstract/Full Text
Comparison of composition-gradient sedimentation equilibrium and composition-gradient static light scattering as techniques for quantitative characterization of biomolecular interactions: A case study.: Arisaka F, Niimura Y, Minton AP.; Anal Biochem (2019 Oct 15) 583:113339. Abstract/Full Text
Quantitative characterization of the concentration-dependent interaction between molecules of Dextran 70 in aqueous solution: Measurement and analysis in the context of thermodynamic and compressible sphere models.: Fernández C, Fodeke AA, Minton AP.; Biopolymers (2019 Oct) 110:e23284. Abstract/Full Text
An Equilibrium Model for the Combined Effect of Macromolecular Crowding and Surface Adsorption on the Formation of Linear Protein Fibrils.: Hoppe T, Minton AP.; Biophys J (2019 Jun 4) 116:2234. Abstract/Full Text
Non-specific Interactions Between Macromolecular Solutes in Concentrated Solution: Physico-Chemical Manifestations and Biochemical Consequences.: Hoppe T, Minton AP.; Front Mol Biosci (2019) 6:10. Abstract/Full Text
Comparison of the thermal stabilization of proteins by oligosaccharides and monosaccharide mixtures: Measurement and analysis in the context of excluded volume theory.: Beg I, Minton AP, Islam A, Hassan MI, Ahmad F.; Biophys Chem (2018 Jun) 237:31-37. Abstract/Full Text
Toward an understanding of biochemical equilibria within living cells.: Rivas G, Minton AP.; Biophys Rev (2018 Apr) 10:241-253. Abstract/Full Text
Explicit Incorporation of Hard and Soft Protein-Protein Interactions into Models for Crowding Effects in Protein Mixtures. 2. Effects of Varying Hard and Soft Interactions upon Prototypical Chemical Equilibria.: Minton AP.; J Phys Chem B (2017 Jun 8) 121:5515-5522. Abstract/Full Text
The pH Dependence of Saccharides' Influence on Thermal Denaturation of Two Model Proteins Supports an Excluded Volume Model for Stabilization Generalized to Allow for Intramolecular Electrostatic Interactions.: Beg I, Minton AP, Islam A, Hassan MI, Ahmad F.; J Biol Chem (2017 Jan 13) 292:505-511. Abstract/Full Text
Incorporation of Hard and Soft Protein-Protein Interactions into Models for Crowding Effects in Binary and Ternary Protein Mixtures. Comparison of Approximate Analytical Solutions with Numerical Simulation.: Hoppe T, Minton AP.; J Phys Chem B (2016 Nov 23) 120:11866-11872. Abstract/Full Text
Macromolecular Crowding In Vitro, In Vivo, and In Between.: Rivas G, Minton AP.; Trends Biochem Sci (2016 Nov) 41:970-981. Abstract/Full Text
Modulation of Conformational Equilibria in the S-Adenosylmethionine (SAM) II Riboswitch by SAM, Mg(2+), and Trimethylamine N-Oxide.: McPhie P, Brown P, Chen B, Dayie TK, Minton AP.; Biochemistry (2016 Sep 13) 55:5010-20. Abstract/Full Text
Recent applications of light scattering measurement in the biological and biopharmaceutical sciences.: Minton AP.; Anal Biochem (2016 May 15) 501:4-22. Abstract/Full Text
Thermal Stabilization of Proteins by Mono- and Oligosaccharides: Measurement and Analysis in the Context of an Excluded Volume Model.: Beg I, Minton AP, Hassan I, Islam A, Ahmad F.; Biochemistry (2015 Jun 16) 54:3594-603. Abstract/Full Text
An equilibrium model for the combined effect of macromolecular crowding and surface adsorption on the formation of linear protein fibrils.: Hoppe T, Minton AP.; Biophys J (2015 Feb 17) 108:957-966. Abstract/Full Text
Quantitative characterization of nonspecific self- and hetero-interactions of proteins in nonideal solutions via static light scattering.: Wu D, Minton AP.; J Phys Chem B (2015 Feb 5) 119:1891-8. Abstract/Full Text
Concentration-dependent viscosity of binary and ternary mixtures of nonassociating proteins: measurement and analysis.: Grupi A, Minton AP.; J Phys Chem B (2013 Nov 7) 117:13861-5. Abstract/Full Text
Quantitative characterization of the compensating effects of trimethylamine-N-oxide and guanidine hydrochloride on the dissociation of human cyanmethmoglobin.: Wu D, Minton AP.; J Phys Chem B (2013 Aug 15) 117:9395-9. Abstract/Full Text
Compensating effects of urea and trimethylamine-N-oxide on the heteroassociation of α-chymotrypsin and soybean trypsin inhibitor.: Wu D, Minton AP.; J Phys Chem B (2013 Apr 4) 117:3554-9. Abstract/Full Text
Quantitative assessment of the relative contributions of steric repulsion and chemical interactions to macromolecular crowding.: Minton AP.; Biopolymers (2013 Apr) 99:239-44. Abstract/Full Text
Quantitative characterization of the interaction between sucrose and native proteins via static light scattering.: Wu D, Minton AP.; J Phys Chem B (2013 Jan 10) 117:111-7. Abstract/Full Text
Capillary viscometer for fully automated measurement of the concentration and shear dependence of the viscosity of macromolecular solutions.: Grupi A, Minton AP.; Anal Chem (2012 Dec 18) 84:10732-6. Abstract/Full Text
Dynamic interaction of the Escherichia coli cell division ZipA and FtsZ proteins evidenced in nanodiscs.: Hernández-Rocamora VM, Reija B, García C, Natale P, Alfonso C, Minton AP, Zorrilla S, Rivas G, Vicente M.; J Biol Chem (2012 Aug 31) 287:30097-104. Abstract/Full Text
Hard quasispherical particle models for the viscosity of solutions of protein mixtures.: Minton AP.; J Phys Chem B (2012 Aug 9) 116:9310-5. Abstract/Full Text
An equilibrium model for the Mg(2+)-linked self-assembly of FtsZ in the presence of GTP or a GTP analogue.: Monterroso B, Rivas G, Minton AP.; Biochemistry (2012 Aug 7) 51:6108-13. Abstract/Full Text
Mg(2+)-linked self-assembly of FtsZ in the presence of GTP or a GTP analogue involves the concerted formation of a narrow size distribution of oligomeric species.: Monterroso B, Ahijado-Guzmán R, Reija B, Alfonso C, Zorrilla S, Minton AP, Rivas G.; Biochemistry (2012 Jun 5) 51:4541-50. Abstract/Full Text
Quantitative characterization of temperature-independent and temperature-dependent protein-protein interactions in highly nonideal solutions.: Fodeke AA, Minton AP.; J Phys Chem B (2011 Sep 29) 115:11261-8. Abstract/Full Text
Modulation of functionally significant conformational equilibria in adenylate kinase by high concentrations of trimethylamine oxide attributed to volume exclusion.: Nagarajan S, Amir D, Grupi A, Goldenberg DP, Minton AP, Haas E.; Biophys J (2011 Jun 22) 100:2991-9. Abstract/Full Text
Beyond the second virial coefficient: Sedimentation equilibrium in highly non-ideal solutions.: Rivas G, Minton AP.; Methods (2011 May) 54:167-74. Abstract/Full Text
Effect of nonadditive repulsive intermolecular interactions on the light scattering of concentrated protein-osmolyte mixtures.: Fernández C, Minton AP.; J Phys Chem B (2011 Feb 10) 115:1289-93. Abstract/Full Text
Characterization of self-association and heteroassociation of bacterial cell division proteins FtsZ and ZipA in solution by composition gradient-static light scattering.: Martos A, Alfonso C, López-Navajas P, Ahijado-Guzmn R, Mingorance J, Minton AP, Rivas G.; Biochemistry (2010 Dec 28) 49:10780-7. Abstract/Full Text
Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering.: Scherer TM, Liu J, Shire SJ, Minton AP.; J Phys Chem B (2010 Oct 14) 114:12948-57. Abstract/Full Text
Quantitative characterization of polymer-polymer, protein-protein, and polymer-protein interaction via tracer sedimentation equilibrium.: Fodeke AA, Minton AP.; J Phys Chem B (2010 Aug 26) 114:10876-80. Abstract/Full Text
Attractive protein-polymer interactions markedly alter the effect of macromolecular crowding on protein association equilibria.: Jiao M, Li HT, Chen J, Minton AP, Liang Y.; Biophys J (2010 Aug 4) 99:914-23. Abstract/Full Text
Self-association of Zn-insulin at neutral pH: investigation by concentration gradient--static and dynamic light scattering.: Attri AK, Fernández C, Minton AP.; Biophys Chem (2010 May) 148:23-7. Abstract/Full Text
pH-dependent self-association of zinc-free insulin characterized by concentration-gradient static light scattering.: Attri AK, Fernández C, Minton AP.; Biophys Chem (2010 May) 148:28-33. Abstract/Full Text
Static light scattering from concentrated protein solutions II: experimental test of theory for protein mixtures and weakly self-associating proteins.: Fernández C, Minton AP.; Biophys J (2009 Mar 4) 96:1992-8. Abstract/Full Text
Automated measurement of the static light scattering of macromolecular solutions over a broad range of concentrations.: Fernández C, Minton AP.; Anal Biochem (2008 Oct 15) 381:254-7. Abstract/Full Text
Effective hard particle model for the osmotic pressure of highly concentrated binary protein solutions.: Minton AP.; Biophys J (2008 Apr 1) 94:L57-9. Abstract/Full Text
Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences.: Zhou HX, Rivas G, Minton AP.; Annu Rev Biophys (2008) 37:375-97. Abstract/Full Text
The effective hard particle model provides a simple, robust, and broadly applicable description of nonideal behavior in concentrated solutions of bovine serum albumin and other nonassociating proteins.: Minton AP.; J Pharm Sci (2007 Dec) 96:3466-9. Abstract/Full Text
Static light scattering from concentrated protein solutions, I: General theory for protein mixtures and application to self-associating proteins.: Minton AP.; Biophys J (2007 Aug 15) 93:1321-8. Abstract/Full Text
Quantitative characterization of weak self-association in concentrated solutions of immunoglobulin G via the measurement of sedimentation equilibrium and osmotic pressure.: Jiménez M, Rivas G, Minton AP.; Biochemistry (2007 Jul 17) 46:8373-8. Abstract/Full Text
How can biochemical reactions within cells differ from those in test tubes?: Minton AP.; J Cell Sci (2006 Jul 15) 119:2863-9. Abstract/Full Text
Protein aggregation in crowded environments.: Ellis RJ, Minton AP.; Biol Chem (2006 May) 387:485-97. Abstract/Full Text

Books & Book Chapters

"Effects of macromolecular crowding on association equilibria and kinetics.": Minton AP.; Encyclopedia of Biophysics.; Roberts GCK, ed.; Springer (Berlin). (2012).
"The effect of time-dependent macromolecular crowding on the kinetics of protein aggregation: a simple model for the onset of age-related neurodegenerative disease.": Bjarnason JB, Botos I, Fox JW, Jia LG, Meyer EF; Frontiers in Physics.; Higher Education Press. (1995) 2:48.

Last Reviewed January 2024