Allen P. Minton, Ph.D.

Photo of Dr. Allen Minton
Scientific Focus Areas: Biomedical Engineering and Biophysics

Publications

A selection of recent and significant publications can be viewed below.

Comparison of the thermal stabilization of proteins by oligosaccharides and monosaccharide mixtures: Measurement and analysis in the context of excluded volume theory.
Beg I, Minton AP, Islam A, Hassan MI, Ahmad F.
Biophys Chem (2018 Jun) 237:31-37. Abstract/Full Text
Toward an understanding of biochemical equilibria within living cells.
Rivas G, Minton AP.
Biophys Rev (2018 Apr) 10:241-253. Abstract/Full Text
Nucleotide and receptor density modulate binding of bacterial division FtsZ protein to ZipA containing lipid-coated microbeads.
Sobrinos-Sanguino M, Zorrilla S, Monterroso B, Minton AP, Rivas G.
Sci Rep (2017 Oct 20) 7:13707. Abstract/Full Text
Explicit Incorporation of Hard and Soft Protein-Protein Interactions into Models for Crowding Effects in Protein Mixtures. 2. Effects of Varying Hard and Soft Interactions upon Prototypical Chemical Equilibria.
Minton AP.
J Phys Chem B (2017 Jun 8) 121:5515-5522. Abstract/Full Text
The pH Dependence of Saccharides' Influence on Thermal Denaturation of Two Model Proteins Supports an Excluded Volume Model for Stabilization Generalized to Allow for Intramolecular Electrostatic Interactions.
Beg I, Minton AP, Islam A, Hassan MI, Ahmad F.
J Biol Chem (2017 Jan 13) 292:505-511. Abstract/Full Text
Incorporation of Hard and Soft Protein-Protein Interactions into Models for Crowding Effects in Binary and Ternary Protein Mixtures. Comparison of Approximate Analytical Solutions with Numerical Simulation.
Hoppe T, Minton AP.
J Phys Chem B (2016 Nov 23) 120:11866-11872. Abstract/Full Text
Macromolecular Crowding In Vitro, In Vivo, and In Between.
Rivas G, Minton AP.
Trends Biochem Sci (2016 Nov) 41:970-981. Abstract/Full Text
Modulation of Conformational Equilibria in the S-Adenosylmethionine (SAM) II Riboswitch by SAM, Mg(2+), and Trimethylamine N-Oxide.
McPhie P, Brown P, Chen B, Dayie TK, Minton AP.
Biochemistry (2016 Sep 13) 55:5010-20. Abstract/Full Text
Recent applications of light scattering measurement in the biological and biopharmaceutical sciences.
Minton AP.
Anal Biochem (2016 May 15) 501:4-22. Abstract/Full Text
Thermal Stabilization of Proteins by Mono- and Oligosaccharides: Measurement and Analysis in the Context of an Excluded Volume Model.
Beg I, Minton AP, Hassan I, Islam A, Ahmad F.
Biochemistry (2015 Jun 16) 54:3594-603. Abstract/Full Text
An equilibrium model for the combined effect of macromolecular crowding and surface adsorption on the formation of linear protein fibrils.
Hoppe T, Minton AP.
Biophys J (2015 Feb 17) 108:957-966. Abstract/Full Text
Quantitative characterization of nonspecific self- and hetero-interactions of proteins in nonideal solutions via static light scattering.
Wu D, Minton AP.
J Phys Chem B (2015 Feb 5) 119:1891-8. Abstract/Full Text
Concentration-dependent viscosity of binary and ternary mixtures of nonassociating proteins: measurement and analysis.
Grupi A, Minton AP.
J Phys Chem B (2013 Nov 7) 117:13861-5. Abstract/Full Text
Quantitative characterization of the compensating effects of trimethylamine-N-oxide and guanidine hydrochloride on the dissociation of human cyanmethmoglobin.
Wu D, Minton AP.
J Phys Chem B (2013 Aug 15) 117:9395-9. Abstract/Full Text
Compensating effects of urea and trimethylamine-N-oxide on the heteroassociation of α-chymotrypsin and soybean trypsin inhibitor.
Wu D, Minton AP.
J Phys Chem B (2013 Apr 4) 117:3554-9. Abstract/Full Text
Quantitative assessment of the relative contributions of steric repulsion and chemical interactions to macromolecular crowding.
Minton AP.
Biopolymers (2013 Apr) 99:239-44. Abstract/Full Text
Quantitative characterization of the interaction between sucrose and native proteins via static light scattering.
Wu D, Minton AP.
J Phys Chem B (2013 Jan 10) 117:111-7. Abstract/Full Text
Capillary viscometer for fully automated measurement of the concentration and shear dependence of the viscosity of macromolecular solutions.
Grupi A, Minton AP.
Anal Chem (2012 Dec 18) 84:10732-6. Abstract/Full Text
Dynamic interaction of the Escherichia coli cell division ZipA and FtsZ proteins evidenced in nanodiscs.
Hernández-Rocamora VM, Reija B, García C, Natale P, Alfonso C, Minton AP, Zorrilla S, Rivas G, Vicente M.
J Biol Chem (2012 Aug 31) 287:30097-104. Abstract/Full Text
Hard quasispherical particle models for the viscosity of solutions of protein mixtures.
Minton AP.
J Phys Chem B (2012 Aug 9) 116:9310-5. Abstract/Full Text
An equilibrium model for the Mg(2+)-linked self-assembly of FtsZ in the presence of GTP or a GTP analogue.
Monterroso B, Rivas G, Minton AP.
Biochemistry (2012 Aug 7) 51:6108-13. Abstract/Full Text
Mg(2+)-linked self-assembly of FtsZ in the presence of GTP or a GTP analogue involves the concerted formation of a narrow size distribution of oligomeric species.
Monterroso B, Ahijado-Guzmán R, Reija B, Alfonso C, Zorrilla S, Minton AP, Rivas G.
Biochemistry (2012 Jun 5) 51:4541-50. Abstract/Full Text
Quantitative characterization of temperature-independent and temperature-dependent protein-protein interactions in highly nonideal solutions.
Fodeke AA, Minton AP.
J Phys Chem B (2011 Sep 29) 115:11261-8. Abstract/Full Text
Modulation of functionally significant conformational equilibria in adenylate kinase by high concentrations of trimethylamine oxide attributed to volume exclusion.
Nagarajan S, Amir D, Grupi A, Goldenberg DP, Minton AP, Haas E.
Biophys J (2011 Jun 22) 100:2991-9. Abstract/Full Text
Beyond the second virial coefficient: Sedimentation equilibrium in highly non-ideal solutions.
Rivas G, Minton AP.
Methods (2011 May) 54:167-74. Abstract/Full Text
Effect of nonadditive repulsive intermolecular interactions on the light scattering of concentrated protein-osmolyte mixtures.
Fernández C, Minton AP.
J Phys Chem B (2011 Feb 10) 115:1289-93. Abstract/Full Text
Characterization of self-association and heteroassociation of bacterial cell division proteins FtsZ and ZipA in solution by composition gradient-static light scattering.
Martos A, Alfonso C, López-Navajas P, Ahijado-Guzmn R, Mingorance J, Minton AP, Rivas G.
Biochemistry (2010 Dec 28) 49:10780-7. Abstract/Full Text
Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering.
Scherer TM, Liu J, Shire SJ, Minton AP.
J Phys Chem B (2010 Oct 14) 114:12948-57. Abstract/Full Text
Quantitative characterization of polymer-polymer, protein-protein, and polymer-protein interaction via tracer sedimentation equilibrium.
Fodeke AA, Minton AP.
J Phys Chem B (2010 Aug 26) 114:10876-80. Abstract/Full Text
Attractive protein-polymer interactions markedly alter the effect of macromolecular crowding on protein association equilibria.
Jiao M, Li HT, Chen J, Minton AP, Liang Y.
Biophys J (2010 Aug 4) 99:914-23. Abstract/Full Text
A didactic model of macromolecular crowding effects on protein folding.
Tsao D, Minton AP, Dokholyan NV.
PLoS One (2010 Aug 3) 5:e11936. Abstract/Full Text
Sequential assembly of the wedge of the baseplate of phage T4 in the presence and absence of gp11 as monitored by analytical ultracentrifugation.
Yap ML, Mio K, Ali S, Minton A, Kanamaru S, Arisaka F.
Macromol Biosci (2010 Jul 7) 10:808-13. Abstract/Full Text
Self-association of Zn-insulin at neutral pH: investigation by concentration gradient--static and dynamic light scattering.
Attri AK, Fernández C, Minton AP.
Biophys Chem (2010 May) 148:23-7. Abstract/Full Text
pH-dependent self-association of zinc-free insulin characterized by concentration-gradient static light scattering.
Attri AK, Fernández C, Minton AP.
Biophys Chem (2010 May) 148:28-33. Abstract/Full Text
Analysis of membrane binding equilibria of peripheral proteins: allowance for excluded area of bound protein.
Minton AP.
Anal Biochem (2010 Feb 15) 397:247-9. Abstract/Full Text
Quantitative characterization of heparin binding to Tau protein: implication for inducer-mediated Tau filament formation.
Zhu HL, Fernández C, Fan JB, Shewmaker F, Chen J, Minton AP, Liang Y.
J Biol Chem (2010 Feb 5) 285:3592-9. Abstract/Full Text
Static light scattering from concentrated protein solutions II: experimental test of theory for protein mixtures and weakly self-associating proteins.
Fernández C, Minton AP.
Biophys J (2009 Mar 4) 96:1992-8. Abstract/Full Text
Analytical ultracentrifugation studies of phage phi29 protein p6 binding to DNA.
Alcorlo M, Jiménez M, Ortega A, Hermoso JM, Salas M, Minton AP, Rivas G.
J Mol Biol (2009 Feb 6) 385:1616-29. Abstract/Full Text
Automated measurement of the static light scattering of macromolecular solutions over a broad range of concentrations.
Fernández C, Minton AP.
Anal Biochem (2008 Oct 15) 381:254-7. Abstract/Full Text
Effective hard particle model for the osmotic pressure of highly concentrated binary protein solutions.
Minton AP.
Biophys J (2008 Apr 1) 94:L57-9. Abstract/Full Text
Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences.
Zhou HX, Rivas G, Minton AP.
Annu Rev Biophys (2008) 37:375-97. Abstract/Full Text
The effective hard particle model provides a simple, robust, and broadly applicable description of nonideal behavior in concentrated solutions of bovine serum albumin and other nonassociating proteins.
Minton AP.
J Pharm Sci (2007 Dec) 96:3466-9. Abstract/Full Text
Effect of high concentration of inert cosolutes on the refolding of an enzyme: carbonic anhydrase B in sucrose and ficoll 70.
Monterroso B, Minton AP.
J Biol Chem (2007 Nov 16) 282:33452-8. Abstract/Full Text
Static light scattering from concentrated protein solutions, I: General theory for protein mixtures and application to self-associating proteins.
Minton AP.
Biophys J (2007 Aug 15) 93:1321-8. Abstract/Full Text
Quantitative characterization of weak self-association in concentrated solutions of immunoglobulin G via the measurement of sedimentation equilibrium and osmotic pressure.
Jiménez M, Rivas G, Minton AP.
Biochemistry (2007 Jul 17) 46:8373-8. Abstract/Full Text
Analytical ultracentrifugation for the study of protein association and assembly.
Howlett GJ, Minton AP, Rivas G.
Curr Opin Chem Biol (2006 Oct) 10:430-6. Abstract/Full Text
Macromolecular crowding stabilizes the molten globule form of apomyoglobin with respect to both cold and heat unfolding.
McPhie P, Ni YS, Minton AP.
J Mol Biol (2006 Aug 4) 361:7-10. Abstract/Full Text
How can biochemical reactions within cells differ from those in test tubes?
Minton AP.
J Cell Sci (2006 Jul 15) 119:2863-9. Abstract/Full Text
Protein aggregation in crowded environments.
Ellis RJ, Minton AP.
Biol Chem (2006 May) 387:485-97. Abstract/Full Text
Macromolecular crowding.
Minton AP.
Curr Biol (2006 Apr 18) 16:R269-71. Abstract/Full Text

Books and Book Chapters

"Effects of macromolecular crowding on association equilibria and kinetics."
Minton AP.
Encyclopedia of Biophysics.
Roberts GCK, ed.
Springer (Berlin). (2012).
"The effect of time-dependent macromolecular crowding on the kinetics of protein aggregation: a simple model for the onset of age-related neurodegenerative disease."
Bjarnason JB, Botos I, Fox JW, Jia LG, Meyer EF
Frontiers in Physics.
Higher Education Press. (1995) 2:48.