Ranganath Muniyappa, M.D., Ph.D.
Photo of Ranganath Muniyappa
Scientific Focus Areas: Cell Biology, Clinical Research, Health Disparities

Clinical Trials

Open studies conducted by NIDDK Principal Investigators appear below. Study statuses may include the following:

  • Open: Recruiting - Currently recruiting participants and open to everyone who meets eligibility criteria.
  • Open: Active, Not Recruiting - Participants are receiving an intervention or being examined, however new participants are not being recruited or enrolled.
  • Open: Enrolling by Invitation - People in a particular population were selected in advance and invited to participate. The study is not open to everyone who meets the eligibility criteria.
  • Open: Available for Expanded Access - Patients who are not participants in the clinical study may be able to gain access to the drug, biologic, or medical device being studied.

Studies Seeking Patients

Physical and Behavioral Traits of Overweight and Obese Adults

This study will describe the phenotype (physical and behavioral traits) of overweight and obese people. It will characterize the hormones, metabolism, food preferences, fitness and physical activity levels, sleep patterns and thought processes in people with and without weight problems. Genetic material will be collected for studies of the internal codes that influence body weight. People over 18 years of age from all weight categories (lean, overweight, obese) who are reasonably healthy may be eligible for this study. Participants undergo the following tests and procedures: - Physical exam, electrocardiogram, blood and urine tests, instructions for recording food intake for 7 days - Metabolic studies for menstruating women. - Resting metabolic rate to study how many calories the body burns at rest. - Mixed meal test to measure hormones such as insulin that regulate blood sugar. - Glucose tolerance test to determine how sensitive the body is to insulin. - 24-hour energy expenditure to measure the amount of oxygen breathed in and the amount of carbon dioxide breathed out. - Repeat 24-hour energy expenditure. - Diurnal blood sampling and temperature assessment to study the body s internal clock. - Air-displacement plethysmography (Bod Pod) to measure body composition. - Dual energy x-ray absortiometry (DEXA) to measure body fat and bone density. - Repeat Bod Pod and DEXA. - Anthropometric measurements and bioelectrical impedance to measure height, weight, and circumferences, skinfold thickness, fluid status and percentage body fat. - Bromide dilution to measure the amount of water not in cells in the body. - Doubly labeled water to measure the amount of calories burned in a 7-day period. - 24-hour diet reports. - Endothelial reactivity to measure how the blood vessels stretch or dilate for assessing cardiovascular health. - Treadmill or bicycle exercise capacity test. - Physical activity monitor. - Unicorder to detect any breathing difficulties that may interfere with sleep. - Fat and muscle biopsy to look for variations in gene expression in fat tissue and muscle. - Neurocognitive testing to check memory, decision-making, hand-eye coordination, and reasoning. - Evaluation of mood problems and assess personality type. - Evaluation to assess the quantity and quality of pain experienced. - Taste testing to determine the response to bitter, salty, sweet and sour substances. - Occupational therapy evaluation to explore the subject s adaptations, if any, for performing personal, social or professional activities; the subject s views on his or her weight, body size and shape, and strategies to control weight.

The trial is Open with a status of Recruiting.

Investigator: Ranganath Muniyappa, M.D.

Referral Contacts: (301) 451-8893

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