Priyanka Narayan, Ph.D., Stadtman Tenure-Track Investigator

Acting Section Chief: Human Disease Section, Genetics & Biochemistry Branch

Scientific Focus Areas: Neuroscience, Cell Biology, Molecular Biology and Biochemistry, Stem Cell Biology

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Publications

A selection of recent and significant publications can be viewed below.

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Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4.: Stephenson RA, Sepulveda J, Johnson KR, Lita A, Gopalakrishnan J, Acri DJ, Beilina A, Cheng L, Yang LG, Root JT, Ward ME, Combs C, Skarnes WC, Cookson MR, Shih HY, Larion M, Rebeck GW, Narayan PS.; Cell Rep (2025 Jul 22) 44:115961. Abstract/Full Text
Apolipoprotein E in lipid metabolism and neurodegenerative disease.: Yang LG, March ZM, Stephenson RA, Narayan PS.; Trends Endocrinol Metab (2023 Aug) 34:430-445. Abstract/Full Text
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.: Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S.; Sci Transl Med (2021 Mar 3) 13. Abstract/Full Text
PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4.: Narayan P, Sienski G, Bonner JM, Lin YT, Seo J, Baru V, Haque A, Milo B, Akay LA, Graziosi A, Freyzon Y, Landgraf D, Hesse WR, Valastyan J, Barrasa MI, Tsai LH, Lindquist S.; Cell Rep (2020 Oct 6) 33:108224. Abstract/Full Text
A reference human induced pluripotent stem cell line for large-scale collaborative studies.: Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Öttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Schüle B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT.; Cell Stem Cell (2022 Dec 1) 29:1685-1702.e22. Abstract/Full Text

Additional Publications

APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.: Cuní-López C, Root JT, Hao Y, Blomberg N, Koppes-den Hertog SJ, Sacks D, Trujillo AE, Ghirlando R, Kowal I, Epstein J, Yang LG, Cookson MR, Marsan E, van der Kant R, Giera M, Qi YA, Narayan PS.; Nat Commun (2026 Aug 19) 17. Abstract/Full Text
APOE4 and INPP5D converge on membrane mechanics to regulate endocytosis in human astrocytes.: Gevorgyan AS, Gordon LM, Combs CA, Lita A, Yang LG, Cuní-López C, Root JT, Larion M, Taraska JW, Narayan PS.; bioRxiv (2026 May 22) Abstract/Full Text
Genome-scale metabolic modeling uncovers cell-type specific signatures associated with APOE variants.: Uzuner Odongo D, Stephenson RA, Cheng L, Yang LG, Narayan PS, Çakır T, Thambisetty M.; iScience (2026 May 15) 29:115638. Abstract/Full Text
Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation in the reference iPSC line KOLF2.1J.: Hao Y, Li Z, Lara E, Ramos DM, Santiana M, Jin B, Epstein J, Kowal I, Camacho J, Carmiol N, Park JH, Beylina A, Yang LG, Root JT, Sacks DC, Jarreau P, Weller CA, Klaisner S, Screven LA, Pantazis CB, Nalls MA, Narayan P, Ferrucci L, Singleton AB, Ward ME, Cookson MR, Qi YA.; Sci Signal (2026 Feb 24) 19:eadx8680. Abstract/Full Text
Random forest model improves annotation and discovery of variants of uncertain significance in Alzheimer's and other neurological disorders.: Jonson C, Makarious MB, Koretsky MJ, Vitale D, Rabkina L, Lago AL, Eslami-Amirabadi M, Ramos EM, Narayan P, Yokoyama JS, Singleton AB, Blauwendraat C, Cookson MR, Nalls MA, Leonard HL.; bioRxiv (2025 Oct 2) Abstract/Full Text
APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics.: Cuní-López C, Root JT, Hao Y, Kowal I, Blomberg N, Ghirlando R, Yang LG, Koppes-den Hertog SJ, Cookson MR, van der Kant R, Giera M, Qi YA, Narayan PS.; bioRxiv (2025 Aug 20) Abstract/Full Text
ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics.: Li Z, Weller CA, Shah S, Johnson NL, Hao Y, Jarreau PB, Roberts J, Guha D, Bereda C, Klaisner S, Machado P, Zanovello M, Prudencio M, Oskarsson B, Staff NP, Dickson DW, Fratta P, Petrucelli L, Narayan P, Cookson MR, Ward ME, Singleton AB, Nalls MA, Qi YA.; Genomics Proteomics Bioinformatics (2025 Jan 15) 22. Abstract/Full Text
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.: Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E, Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS, Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM, Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M, Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM.; Alzheimers Dement (2024 Sep) 20:6590-6605. Abstract/Full Text
Triglyceride metabolism controls inflammation and APOE4 -associated disease states in microglia.: Stephenson RA, Johnson KR, Cheng L, Yang LG, Root JT, Gopalakrishnan J, Shih HY, Narayan PS.; bioRxiv (2024 Apr 13) Abstract/Full Text
A fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline.: Reilly L, Lara E, Ramos D, Li Z, Pantazis CB, Stadler J, Santiana M, Roberts J, Faghri F, Hao Y, Nalls MA, Narayan P, Liu Y, Singleton AB, Cookson MR, Ward ME, Qi YA.; Cell Rep Methods (2023 Oct 23) 3:100593. Abstract/Full Text
Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.: Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M, AMP T2D-GENES Consortium, Myers CL, Boone C, Florez JC, Lindquist S.; Cell (2018 Mar 22) 173:62-73.e9. Abstract/Full Text
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.: Iljina M, Garcia GA, Dear AJ, Flint J, Narayan P, Michaels TC, Dobson CM, Frenkel D, Knowles TP, Klenerman D.; Sci Rep (2016 Jun 27) 6:28658. Abstract/Full Text
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.: Whitcomb DJ, Hogg EL, Regan P, Piers T, Narayan P, Whitehead G, Winters BL, Kim DH, Kim E, St George-Hyslop P, Klenerman D, Collingridge GL, Jo J, Cho K.; Sci Rep (2015 Jun 9) 5:10934. Abstract/Full Text
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).: Ganzinger KA, Narayan P, Qamar SS, Weimann L, Ranasinghe RT, Aguzzi A, Dobson CM, McColl J, St George-Hyslop P, Klenerman D.; Chembiochem (2014 Nov 24) 15:2515-21. Abstract/Full Text
Combating neurodegenerative disease with chemical probes and model systems.: Narayan P, Ehsani S, Lindquist S.; Nat Chem Biol (2014 Nov) 10:911-20. Abstract/Full Text
Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage.: Narayan P, Holmström KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY, Klenerman D.; Biochemistry (2014 Apr 22) 53:2442-53. Abstract/Full Text
Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.: Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S.; Proc Natl Acad Sci U S A (2014 Mar 18) 111:4013-8. Abstract/Full Text
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells.: Narayan P, Ganzinger KA, McColl J, Weimann L, Meehan S, Qamar S, Carver JA, Wilson MR, St George-Hyslop P, Dobson CM, Klenerman D.; J Am Chem Soc (2013 Jan 30) 135:1491-8. Abstract/Full Text
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones.: Narayan P, Meehan S, Carver JA, Wilson MR, Dobson CM, Klenerman D.; Biochemistry (2012 Nov 20) 51:9270-6. Abstract/Full Text
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.: Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, Meehan S, Wilson MR, Dobson CM, Klenerman D.; Nat Struct Mol Biol (2011 Dec 18) 19:79-83. Abstract/Full Text
Design of DNA-conjugated polypeptide-based capture probes for the anchoring of proteins to DNA matrices.: Schweller RM, Constantinou PE, Frankel NW, Narayan P, Diehl MR.; Bioconjug Chem (2008 Dec) 19:2304-7. Abstract/Full Text

Last Reviewed August 2024