We study mechanisms of risk and resilience to neurodegenerative diseases.

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Combating neurodegenerative disease with chemical probes and model systems.
Narayan P, Ehsani S, Lindquist S.
Nat Chem Biol (2014 Nov) 10:911-20. Abstract/Full Text
Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage.
Narayan P, Holmström KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY, Klenerman D.
Biochemistry (2014 Apr 22) 53:2442-53. Abstract/Full Text
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