We study mechanisms of risk and resilience to neurodegenerative diseases.

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APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.
Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S.
Sci Transl Med (2021 Mar 3) 13. Abstract/Full Text
PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4.
Narayan P, Sienski G, Bonner JM, Lin YT, Seo J, Baru V, Haque A, Milo B, Akay LA, Graziosi A, Freyzon Y, Landgraf D, Hesse WR, Valastyan J, Barrasa MI, Tsai LH, Lindquist S.
Cell Rep (2020 Oct 6) 33:108224. Abstract/Full Text
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