Constance Tom Noguchi, Ph.D.

• Acting Chief: Molecular Medicine Branch
• Section Chief: Molecular Cell Biology Section, Molecular Medicine Branch

Scientific Focus Areas: Cell Biology, Immunology, Molecular Biology and Biochemistry

constance.noguchi2@nih.gov 301-496-1163 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

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Neuronal nitric oxide synthase is required for erythropoietin stimulated erythropoiesis in mice.

Lee J, Dey S, Rajvanshi PK, Merling RK, Teng R, Rogers HM, Noguchi CT.

Front Cell Dev Biol (2023) 11:1144110. Abstract/Full Text

Erythropoietin treatment and the risk of hip fractures in hemodialysis patients.

Suresh S, Wright EC, Wright DG, Abbott KC, Noguchi CT.

J Bone Miner Res (2021 Jul) 36:1211-1219. Abstract/Full Text

Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation.

Dey S, Cui Z, Gavrilova O, Zhang X, Gassmann M, Noguchi CT.

JCI Insight (2020 Mar 12) 5. Abstract/Full Text

Erythropoietin modulates bone marrow stromal cell differentiation.

Suresh S, de Castro LF, Dey S, Robey PG, Noguchi CT.

Bone Res (2019) 7:21. Abstract/Full Text

Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production.

Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT.

Nat Commun (2011 Nov 1) 2:520. Abstract/Full Text

Additional Publications

High nitrate levels in skeletal muscle contribute to nitric oxide generation via a nitrate/nitrite reductive pathway in mice that lack the nNOS enzyme.

Upanan S, Lee J, Tunau-Spencer KJ, Rajvanshi PK, Wright EC, Noguchi CT, Schechter AN.

Front Physiol (2024) 15:1352242. Abstract/Full Text

Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.

Lee J, Rogers HM, Springer DA, Noguchi CT.

Front Physiol (2024) 15:1338476. Abstract/Full Text

Hemolysis impairs sickle cell erythropoiesis.

Noguchi CT.

Blood (2024 Mar 14) 143:947-949. Abstract/Full Text

Erythropoietin Non-hematopoietic Tissue Response and Regulation of Metabolism During Diet Induced Obesity.

Dey S, Lee J, Noguchi CT.

Front Pharmacol (2021) 12:725734. Abstract/Full Text

Erythropoietin reduces fat mass in female mice lacking estrogen receptor alpha.

Lee J, Walter MF, Korach KS, Noguchi CT.

Mol Metab (2021 Mar) 45:101142. Abstract/Full Text

Erythropoietin regulates metabolic response in mice via receptor expression in adipose tissue, brain, and bone.

Noguchi CT.

Exp Hematol (2020 Dec) 92:32-42. Abstract/Full Text

Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis.

Suresh S, Lee J, Noguchi CT.

FASEB J (2020 Sep) 34:11685-11697. Abstract/Full Text

The Many Facets of Erythropoietin Physiologic and Metabolic Response.

Suresh S, Rajvanshi PK, Noguchi CT.

Front Physiol (2019) 10:1534. Abstract/Full Text

UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis.

Wang L, Xu Y, Rogers H, Saidi L, Noguchi CT, Li H, Yewdell JW, Guydosh NR, Ye Y.

Cell Res (2020 Jan) 30:5-20. Abstract/Full Text

Compensatory mechanisms in myoglobin deficient mice preserve NO homeostasis.

Park JW, Piknova B, Dey S, Noguchi CT, Schechter AN.

Nitric Oxide (2019 Sep 1) 90:10-14. Abstract/Full Text

Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.

Wang L, Wang Y, Zhang C, Li J, Meng Y, Dou M, Noguchi CT, Di L.

Arterioscler Thromb Vasc Biol (2018 Sep) 38:2103-2116. Abstract/Full Text

Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia.

Mayer B, Németh K, Krepuska M, Myneni VD, Maric D, Tisdale JF, Hsieh MM, Uchida N, Lee HJ, Nemeth MJ, Holmbeck K, Noguchi CT, Rogers H, Dey S, Hansen A, Hong J, Chow I, Key S, Szalayova I, Pagani J, Markó K, McClain-Caldwell I, Vitale-Cross L, Young WS, Brownstein MJ, Mezey É.

Sci Transl Med (2017 Nov 29) 9. Abstract/Full Text

Sex difference in mouse metabolic response to erythropoietin.

Zhang Y, Rogers HM, Zhang X, Noguchi CT.

FASEB J (2017 Jun) 31:2661-2673. Abstract/Full Text

Angiogenic factors are increased in circulating granulocytes and CD34(+) cells of myeloproliferative neoplasms.

Subotički T, Mitrović Ajtić O, Beleslin-Čokić BB, Nienhold R, Diklić M, Djikić D, Leković D, Bulat T, Marković D, Gotić M, Noguchi CT, Schechter AN, Skoda RC, Čokić VP.

Mol Carcinog (2017 Feb) 56:567-579. Abstract/Full Text

Non-hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation.

Reinhardt M, Dey S, Tom Noguchi C, Zhang Y, Krakoff J, Thearle MS.

Obesity (Silver Spring) (2016 Jul) 24:1530-6. Abstract/Full Text

Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response.

Dey S, Li X, Teng R, Alnaeeli M, Chen Z, Rogers H, Noguchi CT.

J Mol Endocrinol (2016 Feb) 56:55-67. Abstract/Full Text

Association of Erythropoietin Dose and Route of Administration with Clinical Outcomes for Patients on Hemodialysis in the United States.

Wright DG, Wright EC, Narva AS, Noguchi CT, Eggers PW.

Clin J Am Soc Nephrol (2015 Oct 7) 10:1822-30. Abstract/Full Text

Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway.

Čokić VP, Mossuz P, Han J, Socoro N, Beleslin-Čokić BB, Mitrović O, Subotički T, Diklić M, Leković D, Gotić M, Puri RK, Noguchi CT, Schechter AN.

PLoS One (2015) 10:e0135463. Abstract/Full Text

Erythropoietin negatively regulates pituitary ACTH secretion.

Dey S, Scullen T, Noguchi CT.

Brain Res (2015 May 22) 1608:14-20. Abstract/Full Text

Skeletal muscle as an endogenous nitrate reservoir.

Piknova B, Park JW, Swanson KM, Dey S, Noguchi CT, Schechter AN.

Nitric Oxide (2015 May 1) 47:10-16. Abstract/Full Text

Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.

Gammella E, Diaz V, Recalcati S, Buratti P, Samaja M, Dey S, Noguchi CT, Gassmann M, Cairo G.

Am J Physiol Regul Integr Comp Physiol (2015 Feb 15) 308:R330-5. Abstract/Full Text

AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes.

Wang L, Di L, Noguchi CT.

Int J Biochem Cell Biol (2014 Sep) 54:1-9. Abstract/Full Text

Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system.

Wang L, Di L, Noguchi CT.

Int J Biol Sci (2014) 10:921-39. Abstract/Full Text

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.

Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG 6th, Noguchi CT, Kato GJ.

Blood (2014 Aug 7) 124:946-54. Abstract/Full Text

Erythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity.

Alnaeeli M, Raaka BM, Gavrilova O, Teng R, Chanturiya T, Noguchi CT.

Diabetes (2014 Jul) 63:2415-31. Abstract/Full Text

Erythropoietin action in stress response, tissue maintenance and metabolism.

Zhang Y, Wang L, Dey S, Alnaeeli M, Suresh S, Rogers H, Teng R, Noguchi CT.

Int J Mol Sci (2014 Jun 10) 15:10296-333. Abstract/Full Text

Nitric oxide and hypoxia stimulate erythropoietin receptor via MAPK kinase in endothelial cells.

Cokic BB, Cokic VP, Suresh S, Wirt S, Noguchi CT.

Microvasc Res (2014 Mar) 92:34-40. Abstract/Full Text

PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders.

Wang L, Teng R, Di L, Rogers H, Wu H, Kopp JB, Noguchi CT.

Diabetes (2013 Dec) 62:4122-31. Abstract/Full Text

Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation.

Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp JB, Yamamoto M, Noguchi CT.

Int J Biochem Cell Biol (2013 Jul) 45:1155-64. Abstract/Full Text

Globin gene expression in correlation with G protein-related genes during erythroid differentiation.

Čokić VP, Smith RD, Biancotto A, Noguchi CT, Puri RK, Schechter AN.

BMC Genomics (2013 Feb 20) 14:116. Abstract/Full Text

Effect of blood nitrite and nitrate levels on murine platelet function.

Park JW, Piknova B, Huang PL, Noguchi CT, Schechter AN.

PLoS One (2013) 8:e55699. Abstract/Full Text

Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.

Yang T, Jian W, Luo Y, Fu X, Noguchi C, Bungert J, Huang S, Qiu Y.

J Biol Chem (2012 Nov 23) 287:40279-91. Abstract/Full Text

T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.

Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT.

J Biol Chem (2012 Oct 26) 287:36720-31. Abstract/Full Text

GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).

Wang L, Jia Y, Rogers H, Wu YP, Huang S, Noguchi CT.

J Biol Chem (2012 Aug 31) 287:30157-69. Abstract/Full Text

Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage.

Jia Y, Suzuki N, Yamamoto M, Gassmann M, Noguchi CT.

FASEB J (2012 Jul) 26:2847-58. Abstract/Full Text

Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells.

Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT.

Cytokine (2011 May) 54:129-35. Abstract/Full Text

Acute erythropoietin cardioprotection is mediated by endothelial response.

Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT.

Basic Res Cardiol (2011 May) 106:343-54. Abstract/Full Text

Up-regulation of erythropoietin receptor by nitric oxide mediates hypoxia preconditioning.

Chen ZY, Wang L, Asavaritkrai P, Noguchi CT.

J Neurosci Res (2010 Nov 1) 88:3180-8. Abstract/Full Text

Erythropoietin signaling promotes transplanted progenitor cell survival.

Jia Y, Warin R, Yu X, Epstein R, Noguchi CT.

FASEB J (2009 Sep) 23:3089-99. Abstract/Full Text

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.

Hu X, Li X, Valverde K, Fu X, Noguchi C, Qiu Y, Huang S.

Proc Natl Acad Sci U S A (2009 Jun 23) 106:10141-6. Abstract/Full Text

Survival and proliferative roles of erythropoietin beyond the erythroid lineage.

Noguchi CT, Wang L, Rogers HM, Teng R, Jia Y.

Expert Rev Mol Med (2008 Dec 1) 10:e36. Abstract/Full Text

Where the Epo cells are.

Noguchi CT.

Blood (2008 May 15) 111:4836-7. Abstract/Full Text

Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells.

Cokic VP, Andric SA, Stojilkovic SS, Noguchi CT, Schechter AN.

Blood (2008 Feb 1) 111:1117-23. Abstract/Full Text

Hypoxia alters progression of the erythroid program.

Rogers HM, Yu X, Wen J, Smith R, Fibach E, Noguchi CT.

Exp Hematol (2008 Jan) 36:17-27. Abstract/Full Text

Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation.

Chen ZY, Asavaritikrai P, Prchal JT, Noguchi CT.

J Biol Chem (2007 Aug 31) 282:25875-83. Abstract/Full Text