Constance Tom Noguchi, Ph.D.
Constance Noguchi.
Scientific Focus Areas: Cell Biology, Immunology, Molecular Biology and Biochemistry


A selection of recent and significant publications can be viewed below.

Select Publications

Neuronal nitric oxide synthase is required for erythropoietin stimulated erythropoiesis in mice.
Lee J, Dey S, Rajvanshi PK, Merling RK, Teng R, Rogers HM, Noguchi CT.
Front Cell Dev Biol (2023) 11:1144110. Abstract/Full Text
Erythropoietin treatment and the risk of hip fractures in hemodialysis patients.
Suresh S, Wright EC, Wright DG, Abbott KC, Noguchi CT.
J Bone Miner Res (2021 Jul) 36:1211-1219. Abstract/Full Text
Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation.
Dey S, Cui Z, Gavrilova O, Zhang X, Gassmann M, Noguchi CT.
JCI Insight (2020 Mar 12) 5. Abstract/Full Text
Erythropoietin modulates bone marrow stromal cell differentiation.
Suresh S, de Castro LF, Dey S, Robey PG, Noguchi CT.
Bone Res (2019) 7:21. Abstract/Full Text
Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production.
Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT.
Nat Commun (2011 Nov 1) 2:520. Abstract/Full Text

Additional Publications

Erythropoietin Non-hematopoietic Tissue Response and Regulation of Metabolism During Diet Induced Obesity.
Dey S, Lee J, Noguchi CT.
Front Pharmacol (2021) 12:725734. Abstract/Full Text
Erythropoietin regulates metabolic response in mice via receptor expression in adipose tissue, brain, and bone.
Noguchi CT.
Exp Hematol (2020 Dec) 92:32-42. Abstract/Full Text
Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis.
Suresh S, Lee J, Noguchi CT.
FASEB J (2020 Sep) 34:11685-11697. Abstract/Full Text
The Many Facets of Erythropoietin Physiologic and Metabolic Response.
Suresh S, Rajvanshi PK, Noguchi CT.
Front Physiol (2019) 10:1534. Abstract/Full Text
UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis.
Wang L, Xu Y, Rogers H, Saidi L, Noguchi CT, Li H, Yewdell JW, Guydosh NR, Ye Y.
Cell Res (2020 Jan) 30:5-20. Abstract/Full Text
Compensatory mechanisms in myoglobin deficient mice preserve NO homeostasis.
Park JW, Piknova B, Dey S, Noguchi CT, Schechter AN.
Nitric Oxide (2019 Sep 1) 90:10-14. Abstract/Full Text
Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.
Wang L, Wang Y, Zhang C, Li J, Meng Y, Dou M, Noguchi CT, Di L.
Arterioscler Thromb Vasc Biol (2018 Sep) 38:2103-2116. Abstract/Full Text
Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia.
Mayer B, Németh K, Krepuska M, Myneni VD, Maric D, Tisdale JF, Hsieh MM, Uchida N, Lee HJ, Nemeth MJ, Holmbeck K, Noguchi CT, Rogers H, Dey S, Hansen A, Hong J, Chow I, Key S, Szalayova I, Pagani J, Markó K, McClain-Caldwell I, Vitale-Cross L, Young WS, Brownstein MJ, Mezey É.
Sci Transl Med (2017 Nov 29) 9. Abstract/Full Text
Sex difference in mouse metabolic response to erythropoietin.
Zhang Y, Rogers HM, Zhang X, Noguchi CT.
FASEB J (2017 Jun) 31:2661-2673. Abstract/Full Text
Angiogenic factors are increased in circulating granulocytes and CD34(+) cells of myeloproliferative neoplasms.
Subotički T, Mitrović Ajtić O, Beleslin-Čokić BB, Nienhold R, Diklić M, Djikić D, Leković D, Bulat T, Marković D, Gotić M, Noguchi CT, Schechter AN, Skoda RC, Čokić VP.
Mol Carcinog (2017 Feb) 56:567-579. Abstract/Full Text
Non-hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation.
Reinhardt M, Dey S, Tom Noguchi C, Zhang Y, Krakoff J, Thearle MS.
Obesity (Silver Spring) (2016 Jul) 24:1530-6. Abstract/Full Text
Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response.
Dey S, Li X, Teng R, Alnaeeli M, Chen Z, Rogers H, Noguchi CT.
J Mol Endocrinol (2016 Feb) 56:55-67. Abstract/Full Text
Association of Erythropoietin Dose and Route of Administration with Clinical Outcomes for Patients on Hemodialysis in the United States.
Wright DG, Wright EC, Narva AS, Noguchi CT, Eggers PW.
Clin J Am Soc Nephrol (2015 Oct 7) 10:1822-30. Abstract/Full Text
Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway.
Čokić VP, Mossuz P, Han J, Socoro N, Beleslin-Čokić BB, Mitrović O, Subotički T, Diklić M, Leković D, Gotić M, Puri RK, Noguchi CT, Schechter AN.
PLoS One (2015) 10:e0135463. Abstract/Full Text
Erythropoietin negatively regulates pituitary ACTH secretion.
Dey S, Scullen T, Noguchi CT.
Brain Res (2015 May 22) 1608:14-20. Abstract/Full Text
Skeletal muscle as an endogenous nitrate reservoir.
Piknova B, Park JW, Swanson KM, Dey S, Noguchi CT, Schechter AN.
Nitric Oxide (2015 May 1) 47:10-16. Abstract/Full Text
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.
Gammella E, Diaz V, Recalcati S, Buratti P, Samaja M, Dey S, Noguchi CT, Gassmann M, Cairo G.
Am J Physiol Regul Integr Comp Physiol (2015 Feb 15) 308:R330-5. Abstract/Full Text
AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes.
Wang L, Di L, Noguchi CT.
Int J Biochem Cell Biol (2014 Sep) 54:1-9. Abstract/Full Text
Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system.
Wang L, Di L, Noguchi CT.
Int J Biol Sci (2014) 10:921-39. Abstract/Full Text
Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.
Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG 6th, Noguchi CT, Kato GJ.
Blood (2014 Aug 7) 124:946-54. Abstract/Full Text
Erythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity.
Alnaeeli M, Raaka BM, Gavrilova O, Teng R, Chanturiya T, Noguchi CT.
Diabetes (2014 Jul) 63:2415-31. Abstract/Full Text
Erythropoietin action in stress response, tissue maintenance and metabolism.
Zhang Y, Wang L, Dey S, Alnaeeli M, Suresh S, Rogers H, Teng R, Noguchi CT.
Int J Mol Sci (2014 Jun 10) 15:10296-333. Abstract/Full Text
Nitric oxide and hypoxia stimulate erythropoietin receptor via MAPK kinase in endothelial cells.
Cokic BB, Cokic VP, Suresh S, Wirt S, Noguchi CT.
Microvasc Res (2014 Mar) 92:34-40. Abstract/Full Text
PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders.
Wang L, Teng R, Di L, Rogers H, Wu H, Kopp JB, Noguchi CT.
Diabetes (2013 Dec) 62:4122-31. Abstract/Full Text
Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation.
Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp JB, Yamamoto M, Noguchi CT.
Int J Biochem Cell Biol (2013 Jul) 45:1155-64. Abstract/Full Text
Globin gene expression in correlation with G protein-related genes during erythroid differentiation.
Čokić VP, Smith RD, Biancotto A, Noguchi CT, Puri RK, Schechter AN.
BMC Genomics (2013 Feb 20) 14:116. Abstract/Full Text
Effect of blood nitrite and nitrate levels on murine platelet function.
Park JW, Piknova B, Huang PL, Noguchi CT, Schechter AN.
PLoS One (2013) 8:e55699. Abstract/Full Text
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
Yang T, Jian W, Luo Y, Fu X, Noguchi C, Bungert J, Huang S, Qiu Y.
J Biol Chem (2012 Nov 23) 287:40279-91. Abstract/Full Text
T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.
Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT.
J Biol Chem (2012 Oct 26) 287:36720-31. Abstract/Full Text
GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).
Wang L, Jia Y, Rogers H, Wu YP, Huang S, Noguchi CT.
J Biol Chem (2012 Aug 31) 287:30157-69. Abstract/Full Text
Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage.
Jia Y, Suzuki N, Yamamoto M, Gassmann M, Noguchi CT.
FASEB J (2012 Jul) 26:2847-58. Abstract/Full Text
JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny.
Cokic VP, Bhattacharya B, Beleslin-Cokic BB, Noguchi CT, Puri RK, Schechter AN.
J Transl Med (2012 Jun 7) 10:116. Abstract/Full Text
Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells.
Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT.
Cytokine (2011 May) 54:129-35. Abstract/Full Text
Acute erythropoietin cardioprotection is mediated by endothelial response.
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT.
Basic Res Cardiol (2011 May) 106:343-54. Abstract/Full Text
Up-regulation of erythropoietin receptor by nitric oxide mediates hypoxia preconditioning.
Chen ZY, Wang L, Asavaritkrai P, Noguchi CT.
J Neurosci Res (2010 Nov 1) 88:3180-8. Abstract/Full Text
Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor.
Xiong Y, Mahmood A, Qu C, Kazmi H, Zhang ZG, Noguchi CT, Schallert T, Chopp M.
J Neurotrauma (2010 Jan) 27:205-15. Abstract/Full Text
Erythropoietin signaling promotes transplanted progenitor cell survival.
Jia Y, Warin R, Yu X, Epstein R, Noguchi CT.
FASEB J (2009 Sep) 23:3089-99. Abstract/Full Text
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.
Hu X, Li X, Valverde K, Fu X, Noguchi C, Qiu Y, Huang S.
Proc Natl Acad Sci U S A (2009 Jun 23) 106:10141-6. Abstract/Full Text
Survival and proliferative roles of erythropoietin beyond the erythroid lineage.
Noguchi CT, Wang L, Rogers HM, Teng R, Jia Y.
Expert Rev Mol Med (2008 Dec 1) 10:e36. Abstract/Full Text
Where the Epo cells are.
Noguchi CT.
Blood (2008 May 15) 111:4836-7. Abstract/Full Text
Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells.
Cokic VP, Andric SA, Stojilkovic SS, Noguchi CT, Schechter AN.
Blood (2008 Feb 1) 111:1117-23. Abstract/Full Text
Hypoxia alters progression of the erythroid program.
Rogers HM, Yu X, Wen J, Smith R, Fibach E, Noguchi CT.
Exp Hematol (2008 Jan) 36:17-27. Abstract/Full Text
The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells.
Wang L, Zhang ZG, Gregg SR, Zhang RL, Jiao Z, LeTourneau Y, Liu X, Feng Y, Gerwien J, Torup L, Leist M, Noguchi CT, Chen ZY, Chopp M.
J Biol Chem (2007 Nov 2) 282:32462-70. Abstract/Full Text
Role of erythropoietin in the brain.
Noguchi CT, Asavaritikrai P, Teng R, Jia Y.
Crit Rev Oncol Hematol (2007 Nov) 64:159-71. Abstract/Full Text
Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation.
Chen ZY, Asavaritikrai P, Prchal JT, Noguchi CT.
J Biol Chem (2007 Aug 31) 282:25875-83. Abstract/Full Text
Last Reviewed November 2023