Paolo Piaggi, Ph.D.

Photo of Paolo Piaggi
Scientific Focus Areas: Biomedical Engineering and Biophysics, Clinical Research, Computational Biology, Epidemiology, Genetics and Genomics


A selection of recent and significant publications can be viewed below.

Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms.
Piaggi P, Vinales KL, Basolo A, Santini F, Krakoff J.
J Endocrinol Invest (2018 Jan) 41:83-89. Abstract/Full Text
Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.
Muller YL, Piaggi P, Chen P, Wiessner G, Okani C, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ.
Diabetes Metab Res Rev (2017 May) 33. Abstract/Full Text
The obese brain as a heritable phenotype: a combined morphometry and twin study.
Weise CM, Piaggi P, Reinhardt M, Chen K, Savage CR, Krakoff J, Pleger B.
Int J Obes (Lond) (2017 Mar) 41:458-466. Abstract/Full Text
Low Elasticity of Thyroid Nodules on Ultrasound Elastography Is Correlated with Malignancy, Degree of Fibrosis, and High Expression of Galectin-3 and Fibronectin-1.
Rago T, Scutari M, Loiacono V, Santini F, Tonacchera M, Torregrossa L, Giannini R, Borrelli N, Proietti A, Basolo F, Miccoli P, Piaggi P, Latrofa F, Vitti P.
Thyroid (2017 Jan) 27:103-110. Abstract/Full Text
The Consistency in Macronutrient Oxidation and the Role for Epinephrine in the Response to Fasting and Overfeeding.
Vinales KL, Schlögl M, Piaggi P, Hohenadel M, Graham A, Bonfiglio S, Krakoff J, Thearle MS.
J Clin Endocrinol Metab (2017 Jan 1) 102:279-289. Abstract/Full Text
In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans.
Frankl J, Piaggi P, Foley JE, Krakoff J, Votruba SB.
Obesity (Silver Spring) (2017 Jan) 25:207-214. Abstract/Full Text
Usefulness of late gadolinium enhancement MRI combined with stress imaging in predictive significant coronary stenosis in new-diagnosed left ventricular dysfunction.
Di Bella G, Pingitore A, Piaggi P, Pizzino F, Barison A, Terrizzi A, d'angelo M, Todiere G, Quattrocchi S, Carerj S, Emdin M, Aquaro GD.
Int J Cardiol (2016 Dec 1) 224:337-342. Abstract/Full Text
Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task.
Chang DC, Piaggi P, Burkholder JE, Votruba SB, Krakoff J, Gluck ME.
Physiol Behav (2016 Dec 1) 167:392-398. Abstract/Full Text
New insights in the molecular signature of advanced medullary thyroid cancer: evidence of a bad outcome of cases with double RET mutations.
Romei C, Casella F, Tacito A, Bottici V, Valerio L, Viola D, Cappagli V, Matrone A, Ciampi R, Piaggi P, Ugolini C, Torregrossa L, Basolo F, Materazzi G, Vitti P, Elisei R.
J Med Genet (2016 Nov) 53:729-734. Abstract/Full Text
Papillary Thyroid Carcinoma With Rare Exon 15 BRAF Mutation Has Indolent Behavior: A Single-Institution Experience.
Torregrossa L, Viola D, Sensi E, Giordano M, Piaggi P, Romei C, Materazzi G, Miccoli P, Elisei R, Basolo F.
J Clin Endocrinol Metab (2016 Nov) 101:4413-4420. Abstract/Full Text
Quantitative Comparison Between Amyloid Deposition Detected by (99m)Tc-Diphosphonate Imaging and Myocardial Deformation Evaluated by Strain Echocardiography in Transthyretin-Related Cardiac Amyloidosis.
Di Bella G, Minutoli F, Piaggi P, Casale M, Mazzeo A, Zito C, Oreto G, Baldari S, Vita G, Pingitore A, Khandheria BK, Carerj S.
Circ J (2016 Aug 25) 80:1998-2003. Abstract/Full Text
The impact of genetic variants on BMI increase during childhood versus adulthood.
Hohenadel MG, Baier LJ, Piaggi P, Muller YL, Hanson RL, Krakoff J, Thearle MS.
Int J Obes (Lond) (2016 Aug) 40:1301-9. Abstract/Full Text
Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.
Nair AK, Piaggi P, McLean NA, Kaur M, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ.
Diabetologia (2016 Mar) 59:481-91. Abstract/Full Text
Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.
Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C.
Diabetes (2016 Feb) 65:510-9. Abstract/Full Text
Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change.
Schlögl M, Piaggi P, Pannacciuli N, Bonfiglio SM, Krakoff J, Thearle MS.
Diabetes (2015 Nov) 64:3680-9. Abstract/Full Text
Neuromodulation targeted to the prefrontal cortex induces changes in energy intake and weight loss in obesity.
Gluck ME, Alonso-Alonso M, Piaggi P, Weise CM, Jumpertz-von Schwartzenberg R, Reinhardt M, Wassermann EM, Venti CA, Votruba SB, Krakoff J.
Obesity (Silver Spring) (2015 Nov) 23:2149-56. Abstract/Full Text
Higher Daily Energy Expenditure and Respiratory Quotient, Rather Than Fat-Free Mass, Independently Determine Greater ad Libitum Overeating.
Piaggi P, Thearle MS, Krakoff J, Votruba SB.
J Clin Endocrinol Metab (2015 Aug) 100:3011-20. Abstract/Full Text
Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate.
Piaggi P, Thearle MS, Bogardus C, Krakoff J.
J Clin Endocrinol Metab (2015 Mar) 100:1078-87. Abstract/Full Text
Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.
Muller YL, Thearle MS, Piaggi P, Hanson RL, Hoffman D, Gene B, Mahkee D, Huang K, Kobes S, Votruba S, Knowler WC, Bogardus C, Baier LJ.
Hum Genet (2014 Nov) 133:1431-41. Abstract/Full Text
Weight maintenance from young adult weight predicts better health outcomes.
Votruba SB, Thearle MS, Piaggi P, Knowler WC, Hanson RL, Krakoff J.
Obesity (Silver Spring) (2014 Nov) 22:2361-9. Abstract/Full Text
Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.
Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C.
Diabetologia (2014 Jul) 57:1382-90. Abstract/Full Text
Lower "awake and fed thermogenesis" predicts future weight gain in subjects with abdominal adiposity.
Piaggi P, Krakoff J, Bogardus C, Thearle MS.
Diabetes (2013 Dec) 62:4043-51. Abstract/Full Text
Overfeeding over 24 hours does not activate brown adipose tissue in humans.
Schlögl M, Piaggi P, Thiyyagura P, Reiman EM, Chen K, Lutrin C, Krakoff J, Thearle MS.
J Clin Endocrinol Metab (2013 Dec) 98:E1956-60. Abstract/Full Text