Paolo Piaggi, Ph.D.
Photo of Paolo Piaggi
Scientific Focus Areas: Biomedical Engineering and Biophysics, Clinical Research, Computational Biology, Epidemiology, Genetics and Genomics


A selection of recent and significant publications can be viewed below.

Higher fasting plasma FGF21 concentration is associated with lower ad libitum soda consumption in humans.
Basolo A, Hollstein T, Shah MH, Walter M, Krakoff J, Votruba SB, Piaggi P.
Am J Clin Nutr (2021 Oct 4) 114:1518-1522. Abstract/Full Text
Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype.
Hollstein T, Basolo A, Ando T, Krakoff J, Piaggi P.
Am J Clin Nutr (2021 Oct 4) 114:1396-1407. Abstract/Full Text
Urinary Dopamine Excretion Rate Decreases during Acute Dietary Protein Deprivation and Is Associated with Increased Plasma Pancreatic Polypeptide Concentration.
Basolo A, Hollstein T, Walter M, Krakoff J, Piaggi P.
Nutrients (2021 Apr 8) 13. Abstract/Full Text
Lower insulin clearance is associated with increased risk of type 2 diabetes in Native Americans.
Shah MH, Piaggi P, Looker HC, Paddock E, Krakoff J, Chang DC.
Diabetologia (2021 Apr) 64:914-922. Abstract/Full Text
Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype.
Hollstein T, Vinales K, Chen KY, Cypess AM, Basolo A, Schlögl M, Krakoff J, Piaggi P.
Metabolism (2021 Apr) 117:154709. Abstract/Full Text
Reduced metabolic efficiency in sedentary eucaloric conditions predicts greater weight regain in adults with obesity following sustained weight loss.
Hollstein T, Heinitz S, Basolo A, Krakoff J, Votruba SB, Piaggi P.
Int J Obes (Lond) (2021 Apr) 45:840-849. Abstract/Full Text
Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians.
Piaggi P, Köroğlu Ç, Nair AK, Sutherland J, Muller YL, Kumar P, Hsueh WC, Kobes S, Shuldiner AR, Kim HI, Gosalia N, Van Hout CV, Jones M, Knowler WC, Krakoff J, Hanson RL, Bogardus C, Baier LJ.
J Clin Endocrinol Metab (2020 Nov 1) 105. Abstract/Full Text
Early adaptive thermogenesis is a determinant of weight loss after six weeks of caloric restriction in overweight subjects.
Heinitz S, Hollstein T, Ando T, Walter M, Basolo A, Krakoff J, Votruba SB, Piaggi P.
Metabolism (2020 Sep) 110:154303. Abstract/Full Text
Metabolic Responses to 24-Hour Fasting and Mild Cold Exposure in Overweight Individuals Are Correlated and Accompanied by Changes in FGF21 Concentration.
Hollstein T, Heinitz S, Ando T, Rodzevik TL, Basolo A, Walter M, Chang DC, Krakoff J, Piaggi P.
Diabetes (2020 Jul) 69:1382-1388. Abstract/Full Text
Metabolic Factors Determining the Susceptibility to Weight Gain: Current Evidence.
Hollstein T, Piaggi P.
Curr Obes Rep (2020 Jun) 9:121-135. Abstract/Full Text
Recharacterizing the Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes.
Hollstein T, Basolo A, Ando T, Votruba SB, Walter M, Krakoff J, Piaggi P.
J Clin Endocrinol Metab (2020 May 1) 105. Abstract/Full Text
Higher Urinary Dopamine Concentration is Associated with Greater Ad Libitum Energy Intake in Humans.
Basolo A, Ando T, Hollstein T, Votruba SB, Krakoff J, Piaggi P.
Obesity (Silver Spring) (2020 May) 28:953-961. Abstract/Full Text
Urinary Norepinephrine Is a Metabolic Determinant of 24-Hour Energy Expenditure and Sleeping Metabolic Rate in Adult Humans.
Hollstein T, Basolo A, Ando T, Votruba SB, Krakoff J, Piaggi P.
J Clin Endocrinol Metab (2020 Apr 1) 105. Abstract/Full Text
Metabolic response to fasting predicts weight gain during low-protein overfeeding in lean men: further evidence for spendthrift and thrifty metabolic phenotypes.
Hollstein T, Ando T, Basolo A, Krakoff J, Votruba SB, Piaggi P.
Am J Clin Nutr (2019 Sep 1) 110:593-604. Abstract/Full Text
Effects of Short-Term Fasting and Different Overfeeding Diets on Thyroid Hormones in Healthy Humans.
Basolo A, Begaye B, Hollstein T, Vinales KL, Walter M, Santini F, Krakoff J, Piaggi P.
Thyroid (2019 Sep) 29:1209-1219. Abstract/Full Text
Cognitive dietary restraint, disinhibition, and hunger are associated with 24-h energy expenditure.
Stinson EJ, Graham AL, Thearle MS, Gluck ME, Krakoff J, Piaggi P.
Int J Obes (Lond) (2019 Jul) 43:1456-1465. Abstract/Full Text
Core body temperature, energy expenditure, and epinephrine during fasting, eucaloric feeding, and overfeeding in healthy adult men: evidence for a ceiling effect for human thermogenic response to diet.
Vinales KL, Begaye B, Thearle MS, Krakoff J, Piaggi P.
Metabolism (2019 May) 94:59-68. Abstract/Full Text
Metabolic Determinants of Weight Gain in Humans.
Piaggi P.
Obesity (Silver Spring) (2019 May) 27:691-699. Abstract/Full Text
A low resting metabolic rate in late childhood is associated with weight gain in adolescence.
Hohenadel MG, Hollstein T, Thearle M, Reinhardt M, Piaggi P, Salbe AD, Krakoff J.
Metabolism (2019 Apr) 93:68-74. Abstract/Full Text
FGF21 Is a Hormonal Mediator of the Human "Thrifty" Metabolic Phenotype.
Vinales KL, Begaye B, Bogardus C, Walter M, Krakoff J, Piaggi P.
Diabetes (2019 Feb) 68:318-323. Abstract/Full Text
Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure.
Heinitz S, Basolo A, Piomelli D, Krakoff J, Piaggi P.
J Clin Endocrinol Metab (2018 Oct 1) 103:3757-3766. Abstract/Full Text
Norepinephrine and T4 Are Predictors of Fat Mass Gain in Humans With Cold-Induced Brown Adipose Tissue Activation.
Begaye B, Piaggi P, Thearle MS, Haskie K, Walter M, Schlögl M, Bonfiglio S, Krakoff J, Vinales KL.
J Clin Endocrinol Metab (2018 Jul 1) 103:2689-2697. Abstract/Full Text
Response of skeletal muscle UCP2-expression during metabolic adaptation to caloric restriction.
Heinitz S, Piaggi P, Yang S, Bonfiglio S, Steel J, Krakoff J, Votruba SB.
Int J Obes (Lond) (2018 Jun) 42:974-984. Abstract/Full Text
Deviations in energy sensing predict long-term weight change in overweight Native Americans.
Basolo A, Votruba SB, Heinitz S, Krakoff J, Piaggi P.
Metabolism (2018 May) 82:65-71. Abstract/Full Text
High Fat and Sugar Consumption During Ad Libitum Intake Predicts Weight Gain.
Stinson EJ, Piaggi P, Ibrahim M, Venti C, Krakoff J, Votruba SB.
Obesity (Silver Spring) (2018 Apr) 26:689-695. Abstract/Full Text
Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage.
Heinitz S, Basolo A, Piaggi P, Piomelli D, Jumpertz von Schwartzenberg R, Krakoff J.
J Clin Endocrinol Metab (2018 Mar 1) 103:1077-1087. Abstract/Full Text
Decline in the acute insulin response in relationship to plasma glucose concentrations.
Heinitz S, Piaggi P, Bogardus C, Krakoff J.
Diabetes Metab Res Rev (2018 Feb) 34. Abstract/Full Text
Cycling Efficiency During Incremental Cycle Ergometry After 24 Hours of Overfeeding or Fasting.
Vinales KL, Schlögl M, Reinhardt M, Thearle MS, Krakoff J, Piaggi P.
Obesity (Silver Spring) (2018 Feb) 26:368-377. Abstract/Full Text
Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms.
Piaggi P, Vinales KL, Basolo A, Santini F, Krakoff J.
J Endocrinol Invest (2018 Jan) 41:83-89. Abstract/Full Text
Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial.
Heinitz S, Reinhardt M, Piaggi P, Weise CM, Diaz E, Stinson EJ, Venti C, Votruba SB, Wassermann EM, Alonso-Alonso M, Krakoff J, Gluck ME.
Am J Clin Nutr (2017 Dec) 106:1347-1357. Abstract/Full Text
Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage.
Heinitz S, Piaggi P, Vinales KL, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R.
Int J Obes (Lond) (2017 Oct) 41:1585-1593. Abstract/Full Text
One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2 diabetes mellitus in Southwestern Native Americans.
Paddock E, Hohenadel MG, Piaggi P, Vijayakumar P, Hanson RL, Knowler WC, Krakoff J, Chang DC.
Diabetologia (2017 Sep) 60:1704-1711. Abstract/Full Text
A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.
Piaggi P, Masindova I, Muller YL, Mercader J, Wiessner GB, Chen P, SIGMA Type 2 Diabetes Consortium., Kobes S, Hsueh WC, Mongalo M, Knowler WC, Krakoff J, Hanson RL, Bogardus C, Baier LJ.
Diabetes (2017 Aug) 66:2284-2295. Abstract/Full Text
Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.
Muller YL, Piaggi P, Chen P, Wiessner G, Okani C, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ.
Diabetes Metab Res Rev (2017 May) 33. Abstract/Full Text
Differential methylation of genes in individuals exposed to maternal diabetes in utero.
Chen P, Piaggi P, Traurig M, Bogardus C, Knowler WC, Baier LJ, Hanson RL.
Diabetologia (2017 Apr) 60:645-655. Abstract/Full Text
The obese brain as a heritable phenotype: a combined morphometry and twin study.
Weise CM, Piaggi P, Reinhardt M, Chen K, Savage CR, Krakoff J, Pleger B.
Int J Obes (Lond) (2017 Mar) 41:458-466. Abstract/Full Text
The Consistency in Macronutrient Oxidation and the Role for Epinephrine in the Response to Fasting and Overfeeding.
Vinales KL, Schlögl M, Piaggi P, Hohenadel M, Graham A, Bonfiglio S, Krakoff J, Thearle MS.
J Clin Endocrinol Metab (2017 Jan 1) 102:279-289. Abstract/Full Text
In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans.
Frankl J, Piaggi P, Foley JE, Krakoff J, Votruba SB.
Obesity (Silver Spring) (2017 Jan) 25:207-214. Abstract/Full Text
Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task.
Chang DC, Piaggi P, Burkholder JE, Votruba SB, Krakoff J, Gluck ME.
Physiol Behav (2016 Dec 1) 167:392-398. Abstract/Full Text
The impact of genetic variants on BMI increase during childhood versus adulthood.
Hohenadel MG, Baier LJ, Piaggi P, Muller YL, Hanson RL, Krakoff J, Thearle MS.
Int J Obes (Lond) (2016 Aug) 40:1301-9. Abstract/Full Text
Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.
Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C.
Diabetes (2016 Feb) 65:510-9. Abstract/Full Text
ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.
Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, Bogardus C.
Diabetes (2015 Dec) 64:4322-32. Abstract/Full Text
Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change.
Schlögl M, Piaggi P, Pannacciuli N, Bonfiglio SM, Krakoff J, Thearle MS.
Diabetes (2015 Nov) 64:3680-9. Abstract/Full Text
Neuromodulation targeted to the prefrontal cortex induces changes in energy intake and weight loss in obesity.
Gluck ME, Alonso-Alonso M, Piaggi P, Weise CM, Jumpertz-von Schwartzenberg R, Reinhardt M, Wassermann EM, Venti CA, Votruba SB, Krakoff J.
Obesity (Silver Spring) (2015 Nov) 23:2149-56. Abstract/Full Text
Higher Daily Energy Expenditure and Respiratory Quotient, Rather Than Fat-Free Mass, Independently Determine Greater ad Libitum Overeating.
Piaggi P, Thearle MS, Krakoff J, Votruba SB.
J Clin Endocrinol Metab (2015 Aug) 100:3011-20. Abstract/Full Text
Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate.
Piaggi P, Thearle MS, Bogardus C, Krakoff J.
J Clin Endocrinol Metab (2015 Mar) 100:1078-87. Abstract/Full Text
Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.
Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C.
Diabetologia (2014 Jul) 57:1382-90. Abstract/Full Text
Lower "awake and fed thermogenesis" predicts future weight gain in subjects with abdominal adiposity.
Piaggi P, Krakoff J, Bogardus C, Thearle MS.
Diabetes (2013 Dec) 62:4043-51. Abstract/Full Text
Overfeeding over 24 hours does not activate brown adipose tissue in humans.
Schlögl M, Piaggi P, Thiyyagura P, Reiman EM, Chen K, Lutrin C, Krakoff J, Thearle MS.
J Clin Endocrinol Metab (2013 Dec) 98:E1956-60. Abstract/Full Text
Lower energy expenditure predicts long-term increases in weight and fat mass.
Piaggi P, Thearle MS, Bogardus C, Krakoff J.
J Clin Endocrinol Metab (2013 Apr) 98:E703-7. Abstract/Full Text