Paolo Piaggi, Ph.D.

Photo of Paolo Piaggi
Scientific Focus Areas: Biomedical Engineering and Biophysics, Clinical Research, Computational Biology, Epidemiology, Genetics and Genomics

Publications

A selection of recent and significant publications can be viewed below.

Metabolic Determinants of Weight Gain in Humans.
Piaggi P.
Obesity (Silver Spring) (2019 May) 27:691-699. Abstract/Full Text
A low resting metabolic rate in late childhood is associated with weight gain in adolescence.
Hohenadel MG, Hollstein T, Thearle M, Reinhardt M, Piaggi P, Salbe AD, Krakoff J.
Metabolism (2019 Apr) 93:68-74. Abstract/Full Text
FGF21 Is a Hormonal Mediator of the Human "Thrifty" Metabolic Phenotype.
Vinales KL, Begaye B, Bogardus C, Walter M, Krakoff J, Piaggi P.
Diabetes (2019 Feb) 68:318-323. Abstract/Full Text
Cognitive dietary restraint, disinhibition, and hunger are associated with 24-h energy expenditure.
Stinson EJ, Graham AL, Thearle MS, Gluck ME, Krakoff J, Piaggi P.
Int J Obes (Lond) (2019 Jan 16) Abstract/Full Text
VO2max is associated with measures of energy expenditure in sedentary condition but does not predict weight change.
Ando T, Piaggi P, Bogardus C, Krakoff J.
Metabolism (2019 Jan) 90:44-51. Abstract/Full Text
Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure.
Heinitz S, Basolo A, Piomelli D, Krakoff J, Piaggi P.
J Clin Endocrinol Metab (2018 Oct 1) 103:3757-3766. Abstract/Full Text
Exenatide has a pronounced effect on energy intake but not energy expenditure in non-diabetic subjects with obesity: A randomized, double-blind, placebo-controlled trial.
Basolo A, Burkholder J, Osgood K, Graham A, Bundrick S, Frankl J, Piaggi P, Thearle MS, Krakoff J.
Metabolism (2018 Aug) 85:116-125. Abstract/Full Text
Norepinephrine and T4 Are Predictors of Fat Mass Gain in Humans With Cold-Induced Brown Adipose Tissue Activation.
Begaye B, Piaggi P, Thearle MS, Haskie K, Walter M, Schlögl M, Bonfiglio S, Krakoff J, Vinales KL.
J Clin Endocrinol Metab (2018 Jul 1) 103:2689-2697. Abstract/Full Text
One-Hour Plasma Glucose Compared With Two-Hour Plasma Glucose in Relation to Diabetic Retinopathy in American Indians.
Paddock E, Looker HC, Piaggi P, Knowler WC, Krakoff J, Chang DC.
Diabetes Care (2018 Jun) 41:1212-1217. Abstract/Full Text
Response of skeletal muscle UCP2-expression during metabolic adaptation to caloric restriction.
Heinitz S, Piaggi P, Yang S, Bonfiglio S, Steel J, Krakoff J, Votruba SB.
Int J Obes (Lond) (2018 Jun) 42:974-984. Abstract/Full Text
Deviations in energy sensing predict long-term weight change in overweight Native Americans.
Basolo A, Votruba SB, Heinitz S, Krakoff J, Piaggi P.
Metabolism (2018 May) 82:65-71. Abstract/Full Text
Identification and functional analysis of a novel G310D variant in the insulin-like growth factor 1 receptor (IGF1R) gene associated with type 2 diabetes in American Indians.
Muller YL, Skelton G, Piaggi P, Chen P, Nair A, Kobes S, Hsueh WC, Knowler WC, Hanson RL, Baier LJ, Bogardus C.
Diabetes Metab Res Rev (2018 May) 34:e2994. Abstract/Full Text
Canagliflozin triggers the FGF23/1,25-dihydroxyvitamin D/PTH axis in healthy volunteers in a randomized crossover study.
Blau JE, Bauman V, Conway EM, Piaggi P, Walter MF, Wright EC, Bernstein S, Courville AB, Collins MT, Rother KI, Taylor SI.
JCI Insight (2018 Apr 19) 3. Abstract/Full Text
High Fat and Sugar Consumption During Ad Libitum Intake Predicts Weight Gain.
Stinson EJ, Piaggi P, Ibrahim M, Venti C, Krakoff J, Votruba SB.
Obesity (Silver Spring) (2018 Apr) 26:689-695. Abstract/Full Text
Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage.
Heinitz S, Basolo A, Piaggi P, Piomelli D, Jumpertz von Schwartzenberg R, Krakoff J.
J Clin Endocrinol Metab (2018 Mar 1) 103:1077-1087. Abstract/Full Text
Decline in the acute insulin response in relationship to plasma glucose concentrations.
Heinitz S, Piaggi P, Bogardus C, Krakoff J.
Diabetes Metab Res Rev (2018 Feb) 34. Abstract/Full Text
Cycling Efficiency During Incremental Cycle Ergometry After 24 Hours of Overfeeding or Fasting.
Vinales KL, Schlögl M, Reinhardt M, Thearle MS, Krakoff J, Piaggi P.
Obesity (Silver Spring) (2018 Feb) 26:368-377. Abstract/Full Text
Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex.
Nair AK, Sutherland JR, Traurig M, Piaggi P, Chen P, Kobes S, Hanson RL, Bogardus C, Baier LJ.
Eur J Hum Genet (2018 Feb) 26:238-246. Abstract/Full Text
Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms.
Piaggi P, Vinales KL, Basolo A, Santini F, Krakoff J.
J Endocrinol Invest (2018 Jan) 41:83-89. Abstract/Full Text
Energy Expenditure and Hormone Responses in Humans After Overeating High-Fructose Corn Syrup Versus Whole-Wheat Foods.
Ibrahim M, Bonfiglio S, Schlögl M, Vinales KL, Piaggi P, Venti C, Walter M, Krakoff J, Thearle MS.
Obesity (Silver Spring) (2018 Jan) 26:141-149. Abstract/Full Text
Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial.
Heinitz S, Reinhardt M, Piaggi P, Weise CM, Diaz E, Stinson EJ, Venti C, Votruba SB, Wassermann EM, Alonso-Alonso M, Krakoff J, Gluck ME.
Am J Clin Nutr (2017 Dec) 106:1347-1357. Abstract/Full Text
Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage.
Heinitz S, Piaggi P, Vinales KL, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R.
Int J Obes (Lond) (2017 Oct) 41:1585-1593. Abstract/Full Text
One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2 diabetes mellitus in Southwestern Native Americans.
Paddock E, Hohenadel MG, Piaggi P, Vijayakumar P, Hanson RL, Knowler WC, Krakoff J, Chang DC.
Diabetologia (2017 Sep) 60:1704-1711. Abstract/Full Text
A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.
Piaggi P, Masindova I, Muller YL, Mercader J, Wiessner GB, Chen P, SIGMA Type 2 Diabetes Consortium., Kobes S, Hsueh WC, Mongalo M, Knowler WC, Krakoff J, Hanson RL, Bogardus C, Baier LJ.
Diabetes (2017 Aug) 66:2284-2295. Abstract/Full Text
Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.
Muller YL, Piaggi P, Chen P, Wiessner G, Okani C, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ.
Diabetes Metab Res Rev (2017 May) 33. Abstract/Full Text
Differential methylation of genes in individuals exposed to maternal diabetes in utero.
Chen P, Piaggi P, Traurig M, Bogardus C, Knowler WC, Baier LJ, Hanson RL.
Diabetologia (2017 Apr) 60:645-655. Abstract/Full Text
The obese brain as a heritable phenotype: a combined morphometry and twin study.
Weise CM, Piaggi P, Reinhardt M, Chen K, Savage CR, Krakoff J, Pleger B.
Int J Obes (Lond) (2017 Mar) 41:458-466. Abstract/Full Text
The Consistency in Macronutrient Oxidation and the Role for Epinephrine in the Response to Fasting and Overfeeding.
Vinales KL, Schlögl M, Piaggi P, Hohenadel M, Graham A, Bonfiglio S, Krakoff J, Thearle MS.
J Clin Endocrinol Metab (2017 Jan 1) 102:279-289. Abstract/Full Text
In Vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans.
Frankl J, Piaggi P, Foley JE, Krakoff J, Votruba SB.
Obesity (Silver Spring) (2017 Jan) 25:207-214. Abstract/Full Text
Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task.
Chang DC, Piaggi P, Burkholder JE, Votruba SB, Krakoff J, Gluck ME.
Physiol Behav (2016 Dec 1) 167:392-398. Abstract/Full Text
The impact of genetic variants on BMI increase during childhood versus adulthood.
Hohenadel MG, Baier LJ, Piaggi P, Muller YL, Hanson RL, Krakoff J, Thearle MS.
Int J Obes (Lond) (2016 Aug) 40:1301-9. Abstract/Full Text
Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.
Nair AK, Piaggi P, McLean NA, Kaur M, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ.
Diabetologia (2016 Mar) 59:481-91. Abstract/Full Text
Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.
Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C.
Diabetes (2016 Feb) 65:510-9. Abstract/Full Text
ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.
Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, Bogardus C.
Diabetes (2015 Dec) 64:4322-32. Abstract/Full Text
Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change.
Schlögl M, Piaggi P, Pannacciuli N, Bonfiglio SM, Krakoff J, Thearle MS.
Diabetes (2015 Nov) 64:3680-9. Abstract/Full Text
Neuromodulation targeted to the prefrontal cortex induces changes in energy intake and weight loss in obesity.
Gluck ME, Alonso-Alonso M, Piaggi P, Weise CM, Jumpertz-von Schwartzenberg R, Reinhardt M, Wassermann EM, Venti CA, Votruba SB, Krakoff J.
Obesity (Silver Spring) (2015 Nov) 23:2149-56. Abstract/Full Text
Assessing FOXO1A as a potential susceptibility locus for type 2 diabetes and obesity in American Indians.
Muller YL, Hanson RL, Wiessner G, Nieboer L, Kobes S, Piaggi P, Abdussamad M, Okani C, Knowler WC, Bogardus C, Baier LJ.
Obesity (Silver Spring) (2015 Oct) 23:1960-5. Abstract/Full Text
The effect of differing patterns of childhood body mass index gain on adult physiology in American Indians.
Thearle MS, Votruba SB, Piaggi P, Muller YL, Hanson RL, Baier LJ, Knowler W, Krakoff J.
Obesity (Silver Spring) (2015 Sep) 23:1872-80. Abstract/Full Text
Higher Daily Energy Expenditure and Respiratory Quotient, Rather Than Fat-Free Mass, Independently Determine Greater ad Libitum Overeating.
Piaggi P, Thearle MS, Krakoff J, Votruba SB.
J Clin Endocrinol Metab (2015 Aug) 100:3011-20. Abstract/Full Text
Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans.
Schlögl M, Piaggi P, Votruba SB, Walter M, Krakoff J, Thearle MS.
Appetite (2015 Jul) 90:154-9. Abstract/Full Text
A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.
Muller YL, Piaggi P, Hanson RL, Kobes S, Bhutta S, Abdussamad M, Leak-Johnson T, Kretzler M, Huang K, Weil EJ, Nelson RG, Knowler WC, Bogardus C, Baier LJ.
Hum Mol Genet (2015 May 15) 24:2985-96. Abstract/Full Text
Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate.
Piaggi P, Thearle MS, Bogardus C, Krakoff J.
J Clin Endocrinol Metab (2015 Mar) 100:1078-87. Abstract/Full Text
Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.
Muller YL, Thearle MS, Piaggi P, Hanson RL, Hoffman D, Gene B, Mahkee D, Huang K, Kobes S, Votruba S, Knowler WC, Bogardus C, Baier LJ.
Hum Genet (2014 Nov) 133:1431-41. Abstract/Full Text
Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP.
Nair AK, Muller YL, McLean NA, Abdussamad M, Piaggi P, Kobes S, Weil EJ, Curtis JM, Nelson RG, Knowler WC, Hanson RL, Baier LJ.
Diabetologia (2014 Nov) 57:2334-8. Abstract/Full Text
Weight maintenance from young adult weight predicts better health outcomes.
Votruba SB, Thearle MS, Piaggi P, Knowler WC, Hanson RL, Krakoff J.
Obesity (Silver Spring) (2014 Nov) 22:2361-9. Abstract/Full Text
Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.
Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C.
Diabetologia (2014 Jul) 57:1382-90. Abstract/Full Text
Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
Huang K, Nair AK, Muller YL, Piaggi P, Bian L, Del Rosario M, Knowler WC, Kobes S, Hanson RL, Bogardus C, Baier LJ.
Obesity (Silver Spring) (2014 Apr) 22:984-8. Abstract/Full Text
Lower "awake and fed thermogenesis" predicts future weight gain in subjects with abdominal adiposity.
Piaggi P, Krakoff J, Bogardus C, Thearle MS.
Diabetes (2013 Dec) 62:4043-51. Abstract/Full Text
Overfeeding over 24 hours does not activate brown adipose tissue in humans.
Schlögl M, Piaggi P, Thiyyagura P, Reiman EM, Chen K, Lutrin C, Krakoff J, Thearle MS.
J Clin Endocrinol Metab (2013 Dec) 98:E1956-60. Abstract/Full Text
Lower energy expenditure predicts long-term increases in weight and fat mass.
Piaggi P, Thearle MS, Bogardus C, Krakoff J.
J Clin Endocrinol Metab (2013 Apr) 98:E703-7. Abstract/Full Text