- M.B.A., Johns Hopkins University, 2005
- M.D., Brown University, 1979
- M.M.Sc., Brown University, 1979
- Sc.B., Brown University, 1976
The ultimate goal is to develop better approaches to diagnose, treat, and eventually cure many congenital or acquired disorders of the bone marrow.
Dr. Griffin Rodgers was named Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) on April 1, 2007. His research interests include:
- genetic diseases: sickle cell anemia, thalassemia, red cell enzymopathies; clinical evaluation of disease severity; treatment, including pharmacological alteration of gene expression and stem cell transplantation.
- molecular genetics of human hemoglobins; gene expression and differentiation in erythroid cells in normal and perturbed hematopoietic states; pharmacological alteration of gene expression.
- hematopoiesis; role of inducible and stochastic factors; hematopoietic stem cell plasticity; identification of early markers of lineage-specific differentiation.
- the development of novel gene therapy strategies and their targeted application in cord blood hematopoietic stem cells.
As a research investigator, Dr. Rodgers is widely recognized for his contributions to the development of hydroxyurea, the first effective—and now FDA approved—therapy for sickle cell anemia. Research has shown that people with sickle cell anemia who took hydroxyurea at the recommended dose had higher survival rates than those who took less than the recommended dose.
Dr. Rodgers and his collaborators reported on a modified blood stem-cell transplant regimen that is highly effective in reversing sickle cell disease with relatively low toxicity, now in more than 60 adults. These results were replicated in adults with sickle cell anemia who were being treated at the University of Illinois and King Abdullah International Medical Research Center, and in children with sickle cell anemia who were being treated at the University of Calgary.
Dr. Rodgers continues to perform basic research to understand the molecular basis of how certain drugs induce gamma-globin gene expression. He is also engaged in investigations into targeting the delta-globin gene as an alternate strategy to therapies of the severe beta-globin disorders.
As Chief of the Molecular and Clinical Hematology Branch at the NIDDK, Dr. Rodgers is responsible for planning and conducting basic and clinical research on selected inherited and acquired diseases of human blood. He uses contemporary biochemical, molecular, and physiological techniques; develops and validates models, including cellular and transgenic systems, to permit the delineation of regulatory mechanisms in normal and pathological hematopoesis and to facilitate pharmacological or molecular genetic approaches to correct or compensate for abnormalities associated with disease states; and expedites the translation of novel basic scientific discovery to the appropriate level of preclinical or clinical investigation.
As Chief of the Molecular Hematology Section, Dr. Rodgers plans and conducts research on the molecular and cellular bases of selected congenital and acquired hematological disorders. He develops quantitative methods that are amenable to sequential applications to express disease severity or activity; examines gene expression and the differentiation of erythroid cells in normal and pathological hematopoietic states; studies the molecular basis of lineage-specific differentiation in hematopoietic stem cells; and develops therapies for hemoglobinopathies and other genetic blood disorders based on the modification of target gene expression.
Applying Our Research
An increased understanding of the molecular mechanisms controlling these events would increase our ability to combat selective cytopenias and could facilitate hematopoietic reconstitution following radiation, chemotherapy, and marrow or primary sclerosing cholangitis (PSC) transplantation. Leukemias and lymphomas are usually regarded as hematopoietic cells frozen at various stages of differentiation; additional insights into the basic mechanism of the differentiation process are important to our understanding of leukemias and lymphomas.
- Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression.
- Zhu J, Chin K, Aerbajinai W, Kumkhaek C, Li H, Rodgers GP.
- Blood (2014 Aug 14) 124:1146-56. Abstract/Full Text
- Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.
- Aerbajinai W, Liu L, Zhu J, Kumkhaek C, Chin K, Rodgers GP.
- J Biol Chem (2016 Apr 15) 291:8549-64. Abstract/Full Text
Research In Plain Language
Dr. Rodgers conducts research on human blood diseases. In one area of his research, Dr. Rodgers studies blood cells. He develops methods that scientists can use to study how blood cells are formed. This helps scientists develop medicine and other treatments for other blood diseases.
He also studies molecules and cells in people with blood diseases. He looks for differences in how genes influence mature red blood cells and those that are still growing, and develops tests to measure and describe the level and severity of disease. Dr. Rodgers looks for ways to move these research findings quickly from the lab to the clinic for further testing.
In a second area of his research, Dr. Rodgers develops therapies for blood diseases. His work helped to create a new medicine to treat a genetic blood disorder called sickle cell anemia. This medicine, called hydroxyurea, was the first medicine approved by the Food and Drug Administration (FDA) to treat this disease. Research shows that people who have this disease and take this medicine at the recommended dose have higher survival rates than people who do not take the recommended dose, or who take the recommended dose and do not respond to the treatment.
Another new treatment involves the transplant of blood stem cells. Transplanting these cells reversed sickle cell disease in more than 60 adults. More than half of these adults were able to stop anti-rejection medications one year after the transplant. Meaning that these adults were able to achieve what is called “stable mixed donor chimerism,” a condition in which a person has two types of cells in their blood—their own cells and cells derived from the donor’s stem cells—with different DNA. The results of this study could help a wider range of people access to this type of treatment. The results were repeated in adult patients at the University of Illinois and King Abdullah International Medical Research Center, and in children with sickle cell anemia who were being treated at the University of Calgary.
Knockdown of glia maturation factor-γ in macrophages increases transferrin receptor 1 protein levels (green). See the article by Aerbajinai et al.
Source: Rodgers G, Austin C, Anderson J, Pawlyk A, Colvis C, Margolis R, Baker J. Glimmers in illuminating the druggable genome. Nat Rev Drug Disc. 17(5): 301-302, 2018.
Source: NIH Molecular and Clinical Hematology Branch
Source: Zhu J, Chin K, Aerbajinai W, Kumkhaek C, Li H, Rodgers GP. Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression. Blood. 2014 Aug 14; 124 (124; 2014 Aug 14; 7):1146-56.
Source: Kumkhaek C, Aerbajinai W, Liu W, Zhu J, Uchida N, Kurlander R, Hsieh MM, Tisdale JF, Rodgers GP. MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway. Blood. 2013 Apr 18; 121 (121; 16; 2013 Apr 18):3216-27.