Griffin P. Rodgers, M.D., M.A.C.P.
Griffin Rodgers.
Scientific Focus Areas: Cell Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Stem Cell Biology, Health Disparities


A selection of recent and significant publications can be viewed below.

Select Publications

Kruppel-like factor 1-GATA1 fusion protein improves the sickle cell disease phenotype in mice both in vitro and in vivo.
Zhu J, Li H, Aerbajinai W, Kumkhaek C, Pirooznia M, Saxena A, Dagur P, Chin K, Rodgers GP.
Blood (2022 Nov 24) 140:2276-2289. Abstract/Full Text
Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression.
Zhu J, Chin K, Aerbajinai W, Kumkhaek C, Li H, Rodgers GP.
Blood (2014 Aug 14) 124:1146-56. Abstract/Full Text
Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway.
Li H, Liu W, Chen W, Zhu J, Deng CX, Rodgers GP.
Sci Rep (2015 Nov 19) 5:16974. Abstract/Full Text
Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype.
Hsieh MM, Fitzhugh CD, Weitzel RP, Link ME, Coles WA, Zhao X, Rodgers GP, Powell JD, Tisdale JF.
JAMA (2014 Jul 2) 312:48-56. Abstract/Full Text
Olfactomedin 4 contributes to hydrogen peroxide-induced NADPH oxidase activation and apoptosis in mouse neutrophils.
Liu W, Liu Y, Li H, Rodgers GP.
Am J Physiol Cell Physiol (2018 Oct 1) 315:C494-C501. Abstract/Full Text

Additional Publications

Olfactomedin 4 Is Not a Precise Marker for Human Intestinal Stem Cells, But Is Involved in Intestinal Carcinogenesis.
Liu W, Rodgers GP.
Gastroenterology (2022 Apr) 162:1001-1004. Abstract/Full Text
OLFM4-RET fusion is an oncogenic driver in small intestine adenocarcinoma.
Liu W, Li H, Aerbajinai W, Botos I, Rodgers GP.
Oncogene (2022 Jan) 41:72-82. Abstract/Full Text
Comparison of CD34(+) cells isolated from frozen cord blood and fresh adult peripheral blood of sickle cell disease patients in gene correction of the sickle mutation at late-stage erythroid differentiation.
Kumkhaek C, Uchida N, Tisdale JF, Rodgers GP.
Br J Haematol (2021 Sep) 194:e80-e84. Abstract/Full Text
Role of MFHAS1 in regulating hepcidin expression via the BMP/SMAD and MAPK/ERK1/2 signalling pathways.
Kumkhaek C, LaChance C, Aerbajinai W, Zhu J, Rodgers GP.
Br J Haematol (2019 Aug) 186:e108-e112. Abstract/Full Text
Natural history of benign ethnic neutropenia in individuals of African ancestry.
Lakhotia R, Aggarwal A, Link ME, Rodgers GP, Hsieh MM.
Blood Cells Mol Dis (2019 Jul) 77:12-16. Abstract/Full Text
Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS.
Aerbajinai W, Ghosh MC, Liu J, Kumkhaek C, Zhu J, Chin K, Rouault TA, Rodgers GP.
Blood Adv (2019 Apr 23) 3:1211-1225. Abstract/Full Text
Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet.
Liu W, Aerbajinai W, Li H, Liu Y, Gavrilova O, Jain S, Rodgers GP.
Endocrinology (2018 Sep 1) 159:3235-3244. Abstract/Full Text
Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia.
Charles BA, Hsieh MM, Adeyemo AA, Shriner D, Ramos E, Chin K, Srivastava K, Zakai NA, Cushman M, McClure LA, Howard V, Flegel WA, Rotimi CN, Rodgers GP.
PLoS One (2018) 13:e0194400. Abstract/Full Text
Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice.
Liu W, Li H, Hong SH, Piszczek GP, Chen W, Rodgers GP.
Oncogene (2016 Oct 6) 35:5237-5247. Abstract/Full Text
Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer.
Liu W, Rodgers GP.
Cancer Metastasis Rev (2016 Jun) 35:201-12. Abstract/Full Text
Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.
Aerbajinai W, Liu L, Zhu J, Kumkhaek C, Chin K, Rodgers GP.
J Biol Chem (2016 Apr 15) 291:8549-64. Abstract/Full Text
HbA2 : biology, clinical relevance and a possible target for ameliorating sickle cell disease.
Steinberg MH, Rodgers GP.
Br J Haematol (2015 Sep) 170:781-7. Abstract/Full Text
Deletion of the olfactomedin 4 gene is associated with progression of human prostate cancer.
Li H, Rodriguez-Canales J, Liu W, Zhu J, Hanson JC, Pack S, Zhuang Z, Emmert-Buck MR, Rodgers GP.
Am J Pathol (2013 Oct) 183:1329-38. Abstract/Full Text
Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease.
Liu W, Yan M, Sugui JA, Li H, Xu C, Joo J, Kwon-Chung KJ, Coleman WG, Rodgers GP.
J Clin Invest (2013 Sep) 123:3751-5. Abstract/Full Text
Glia maturation factor-γ negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages.
Aerbajinai W, Lee K, Chin K, Rodgers GP.
J Immunol (2013 Jun 15) 190:6093-103. Abstract/Full Text
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.
Kumkhaek C, Aerbajinai W, Liu W, Zhu J, Uchida N, Kurlander R, Hsieh MM, Tisdale JF, Rodgers GP.
Blood (2013 Apr 18) 121:3216-27. Abstract/Full Text
Identification and characterization of novel full-length cDNAs expressed during hematopoietic lineage-specific differentiation of cultured human peripheral blood mononuclear cells.
Kumkhaek C, Liu W, Rodgers GP.
Blood Cells Mol Dis (2013 Mar) 50:154-5. Abstract/Full Text
Radil controls neutrophil adhesion and motility through β2-integrin activation.
Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA.
Mol Biol Cell (2012 Dec) 23:4751-65. Abstract/Full Text
Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice.
Liu W, Yan M, Liu Y, McLeish KR, Coleman WG Jr, Rodgers GP.
J Immunol (2012 Sep 1) 189:2460-7. Abstract/Full Text
Glia maturation factor-γ mediates neutrophil chemotaxis.
Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.
J Leukoc Biol (2011 Sep) 90:529-38. Abstract/Full Text
Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1.
Chen L, Li H, Liu W, Zhu J, Zhao X, Wright E, Cao L, Ding I, Rodgers GP.
Carcinogenesis (2011 Jul) 32:986-94. Abstract/Full Text
Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cells.
Zhu J, Chin K, Aerbajinai W, Trainor C, Gao P, Rodgers GP.
Blood (2011 Mar 17) 117:3045-52. Abstract/Full Text
Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis.
Liu W, Lee HW, Liu Y, Wang R, Rodgers GP.
Blood (2010 Dec 2) 116:4938-47. Abstract/Full Text
Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection.
Liu W, Yan M, Liu Y, Wang R, Li C, Deng C, Singh A, Coleman WG Jr, Rodgers GP.
Proc Natl Acad Sci U S A (2010 Jun 15) 107:11056-61. Abstract/Full Text
Neutrophil count in African Americans: lowering the target cutoff to initiate or resume chemotherapy?
Hsieh MM, Tisdale JF, Rodgers GP, Young NS, Trimble EL, Little RF.
J Clin Oncol (2010 Apr 1) 28:1633-7. Abstract/Full Text
Allogeneic hematopoietic stem-cell transplantation for sickle cell disease.
Hsieh MM, Kang EM, Fitzhugh CD, Link MB, Bolan CD, Kurlander R, Childs RW, Rodgers GP, Powell JD, Tisdale JF.
N Engl J Med (2009 Dec 10) 361:2309-17. Abstract/Full Text
SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.
Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers GP.
Blood (2009 Jul 2) 114:187-94. Abstract/Full Text
BP1 motif in the human beta-globin promoter affects beta-globin expression during embryonic/fetal erythropoiesis in transgenic mice bearing the human beta-globin gene.
Zoueva OP, Garrett LJ, Bodine D, Rodgers GP.
Blood Cells Mol Dis (2008 Nov-Dec) 41:244-51. Abstract/Full Text
The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor.
Chin KL, Aerbajinai W, Zhu J, Drew L, Chen L, Liu W, Rodgers GP.
Br J Haematol (2008 Nov) 143:421-32. Abstract/Full Text
Vichinsky E, Rodgers GP, Rachmilewitz E.
Curr Mol Med (2008 Nov) 8:591. Abstract/Full Text
Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia.
Kumkhaek C, Taylor JG 6th, Zhu J, Hoppe C, Kato GJ, Rodgers GP.
Br J Haematol (2008 Apr) 141:254-9. Abstract/Full Text
The economic imperative to conquer diabetes.
Fradkin J, Rodgers GP.
Diabetes Care (2008 Mar) 31:624-5. Abstract/Full Text
Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma.
Liu W, Liu Y, Zhu J, Wright E, Ding I, Rodgers GP.
Clin Cancer Res (2008 Feb 15) 14:1041-9. Abstract/Full Text
Thalidomide induces gamma-globin gene expression through increased reactive oxygen species-mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis.
Aerbajinai W, Zhu J, Gao Z, Chin K, Rodgers GP.
Blood (2007 Oct 15) 110:2864-71. Abstract/Full Text
HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques.
Hsieh MM, Linde NS, Wynter A, Metzger M, Wong C, Langsetmo I, Lin A, Smith R, Rodgers GP, Donahue RE, Klaus SJ, Tisdale JF.
Blood (2007 Sep 15) 110:2140-7. Abstract/Full Text
Expression of hGC-1 is correlated with differentiation of gastric carcinoma.
Liu W, Zhu J, Cao L, Rodgers GP.
Histopathology (2007 Aug) 51:157-65. Abstract/Full Text
Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences.
Hsieh MM, Everhart JE, Byrd-Holt DD, Tisdale JF, Rodgers GP.
Ann Intern Med (2007 Apr 3) 146:486-92. Abstract/Full Text
Hydroxyurea exerts bi-modal dose-dependent effects on erythropoiesis in human cultured erythroid cells via distinct pathways.
Wang M, Tang DC, Liu W, Chin K, Zhu JG, Fibach E, Rodgers GP.
Br J Haematol (2002 Dec) 119:1098-105. Abstract/Full Text
Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait.
Kang EM, Areman EM, David-Ocampo V, Fitzhugh C, Link ME, Read EJ, Leitman SF, Rodgers GP, Tisdale JF.
Blood (2002 Feb 1) 99:850-5. Abstract/Full Text
Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development.
Zhang J, Liu WL, Tang DC, Chen L, Wang M, Pack SD, Zhuang Z, Rodgers GP.
Gene (2002 Jan 23) 283:83-93. Abstract/Full Text
Nitric oxide transport on sickle cell hemoglobin: where does it bind?
Gladwin MT, Ognibene FP, Shelhamer JH, Pease-Fye ME, Noguchi CT, Rodgers GP, Schechter AN.
Free Radic Res (2001 Aug) 35:175-80. Abstract/Full Text
Rapid differentiation of five common alpha-thalassemia genotypes by polymerase chain reaction.
Tang DC, Fucharoen S, Ding I, Rodgers GP.
J Lab Clin Med (2001 Apr) 137:290-5. Abstract/Full Text
Sickle cell anemia therapy: progress since Pauling.
Schechter AN, Rodgers GP.
Science (2000 Jan 28) 287:592-3. Abstract/Full Text
Last Reviewed May 2024