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Cindy N. Roy, Ph.D.

Photo of Dr. Cindy Roy
Iron; Heme Biosynthesis; Terminal Erythropoiesis; Bone Marrow Failure/Myelodysplastic Syndrome; Systemic amyloidosis; Porphyrias

Responsibilities & Activities

The NIDDK Hematology portfolio is focused on basic research to improve the treatment, diagnosis and prevention of non-malignant hematopoietic diseases. My portfolio is comprised of investigator-initiated projects which aim to define the molecular regulators of heme biosynthesis and systemic, cellular and mitochondrial iron-homeostasis as it applies to erythropoiesis and iron overload; the biology of terminal maturation of erythrocytes and leukocytes; and the pathogenesis of bone marrow failure and myelodysplastic syndrome. For projects involving maintenance of hematopoietic stem cell quiescence; transcriptional control of hematopoietic cell fate; or globin transcriptional control, please contact my colleague, Dr. Terry Bishop. I am also the Division of Kidney, Urologic and Hematologic Diseases (KUH) contact for the Porphyria Consortium of the Rare Diseases Clinical Research Network (RDCRN).

Research Programs

Erythropoiesis & Hemoglobin
The molecular and cellular biological pathways involved in erythroid cell differentiation.

Genetic Metabolic Disease
Basic and clinical studies on the pathophysiology and treatment of inborn errors of metabolism and rare genetic metabolic diseases.

Iron & Heme Metabolism, Iron Chelation
The regulation of iron absorption, utilization, and storage.