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Cindy N. Roy, Ph.D.

Photo of Dr. Cindy Roy
Iron; Heme Biosynthesis; Terminal Erythropoiesis; Bone Marrow Failure/Myelodysplastic Syndrome; Systemic amyloidosis; Porphyrias

Responsibilities & Activities

The NIDDK Hematology portfolio is focused on basic research to improve the treatment, diagnosis and prevention of non-malignant hematopoietic diseases. My portfolio is comprised of investigator-initiated projects which aim to define the molecular regulators of heme biosynthesis and systemic, cellular and mitochondrial iron-homeostasis as it applies to erythropoiesis and iron overload; the biology of terminal maturation of erythrocytes and leukocytes; and the pathogenesis of bone marrow failure and myelodysplastic syndrome. For projects involving maintenance of hematopoietic stem cell quiescence; transcriptional control of hematopoietic cell fate; or globin transcriptional control, please contact my colleague, Dr. Terry Bishop. I am also the Division of Kidney, Urologic and Hematologic Diseases (KUH) contact for the Porphyria Consortium of the Rare Diseases Clinical Research Network (RDCRN).

Research Programs

Erythropoiesis & Hemoglobin
The molecular and cellular biological pathways involved in erythroid cell differentiation.

Iron & Heme Metabolism, Iron Chelation
The regulation of iron absorption, utilization, and storage.