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  4. Lisa M. Spain, Ph.D.

Lisa M. Spain, Ph.D.

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Type 1 Diabetes TrialNet clinical trials, clinical and basic research on the etiology and pathogenesis of type 1 diabetes and other autoimmune endocrine diseases

Responsibilities & Activities

I serve as director of the Immunobiology of Type 1 Diabetes and Autoimmune Endocrine Diseases Program. My portfolio includes basic and clinical research on the pathogenic mechanisms of autoimmunity in type 1 diabetes and autoimmune thyroid diseases.

I am the Project Scientist for Type 1 Diabetes TrialNet—an international consortium for the conduct of clinical trials for the prevention and reversal of type 1 diabetes. My special interest is in facilitating biomarker discovery.

I am the Program Director for K01, K08, K12, K23, K24, K25, R03 mentored investigator programs for the division. I provide advice and assistance to applicants, participate in funding decisions, and I am involved in program evaluations as needed.

Research Programs

Clinical Research in Type 1 Diabetes
Determinants, etiology, progression, prevention, and treatment of type 1 diabetes in children and adults.

Pathophysiology of Diabetes & Metabolic Disease
Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.

Committees & Working Groups

  • The Biomarkers Consortium: Inflammation and Immunity Steering Committee, NIDDK Representative
  • NIH Autoimmune Disease Coordinating Committee, NIDDK Representative
  • NIDDK Clinical Sciences Working Group, Member
  • NIDDK/DEM Autoimmunity/Transplantation Working Group, Member