Definition & Facts of Liver Transplant
What is a liver transplant?
A liver transplant is surgery to remove your diseased or injured liver and replace it with a healthy liver from another person, called a donor. If your liver stops working properly, called liver failure, a liver transplant can save your life.
How common are liver transplants?
In 2015, about 7,100 liver transplants were performed in the United States. Of these, almost 600 were performed in patients 17 years of age and younger.1
When do people need a liver transplant?
People need a liver transplant when their liver fails due to disease or injury.
For adults in the United States, the most common reasons for needing a liver transplant in 2016 were1
- alcoholic liver disease
- cancers that start in the liver combined with cirrhosis
- fatty liver disease (nonalcoholic steatohepatitis)
- cirrhosis caused by chronic hepatitis C
Biliary atresia is the most common reason children need a liver transplant.1
People may also need a liver transplant due to acute liver failure. Acute liver failure is an uncommon condition most often caused by taking too much acetaminophen.2 Other causes of acute liver failure include
- bad reactions to prescription medicines, illegal drugs, and herbal medicines
- viral hepatitis
- blockage of the blood vessels to the liver
- autoimmune diseases
- genetic disorders
What are the types of liver transplant?
Deceased donor transplants
Most livers for transplants come from people who have just died, called deceased donors. During a deceased donor transplant, surgeons remove your diseased or injured liver and replace it with the deceased donor’s liver. Adults typically receive the entire liver from a deceased donor. However, surgeons may split a deceased donor’s liver into two parts. The larger part may go to an adult, and the smaller part may go to a smaller adult or child.
Living donor transplants
Sometimes a healthy living person will donate part of his or her liver, most often to a family member who is recommended for a liver transplant. This type of donor is called a living donor. During a living donor transplant, surgeons remove a part of the living donor’s healthy liver. Surgeons remove your diseased or injured liver and replace it with the part from the living donor. The living donor’s liver grows back to normal size soon after the surgery. The part of the liver that you receive also grows to normal size. Living donor transplants are less common than deceased donor transplants.
What are the survival rates after a liver transplant?
For patients receiving liver transplants from deceased donors, the survival rates are1
- 86 percent at 1 year
- 78 percent at 3 years
- 72 percent at 5 years
The 20-year survival rate is about 53 percent.3
Your chances of a successful liver transplant and long-term survival depend on your personal situation.
This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.
The NIDDK would like to thank:
Michael R. Lucey, M.D., University of Wisconsin–Madison