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Research Update
Researchers discovered 24 new areas and confirmed 29 other previously identified areas of the genome that are associated with kidney function or development.
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Research Update
The kidneys are less able to maintain salt and mineral balance in chronic kidney disease. Studies find that a fibroblast growth factor, FGF-23, may play a role.
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Research Update
Five studies of the complex system of regulation in kidney fibrosis following injury identified potential targets to prevent or reverse kidney fibrosis.
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Research Update
A new imaging technique allows scientists to see deep into the kidney’s internal structures and gain novel insights about cisplatin-induced CKD in mice.
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Research Update
Using genetically engineered mice, scientists found existing kidney cells and bone marrow were sources of myofibroblasts—contributors to kidney fibrosis.
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Research Update
Kidney transplant study shows a survival benefit for people who received kidney transplants from HLA-incompatible live donors compared with two control groups.
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Research Update
More podocyte genetic material in urine of people with glomerular disease and progressive kidney disease offers possibility of new approach to monitoring CKD.
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Research Update
African Americans with chronic kidney disease and two copies of the APOL1 gene are more likely to progress to kidney failure, suggesting need for new screening.
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Research Update
Cilia, tiny hair-like structures on the kidney, and polycystin-1 and 2 genes, work together to promote cyst growth in mice with polycystic kidney disease.
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Research Update
Study identifies a new bodily defense mechanism, the lipocalin 2 (LCN2) molecule, that appears to help in the fight against urinary tract infections (UTIs).
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Research Update
As patient's progress from chronic kidney disease to kidney failure, ventricular hypertrophy was stable but the heart’s ejection fraction efficiency decreased.
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Research Update
Study finds that kidney function in donors did not deteriorate 3 years after donation. Increases in mGFR and eGFR in donors suggest improved kidney function.
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Research Update
Researchers have produced a reference source that shows in detail how healthy adult human kidneys are organized at the cellular level.
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News Release
On this World Kidney Day, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, joins organizations around the world in highlighting the importance of this year’s theme, “Kidney Health for Everyone, Everywhere.”
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News Release
Acute kidney injury (AKI) and chronic kidney disease (CKD) are closely intertwined, with each disease a risk factor for developing the other and sharing other risk factors in common, as well as sharing causes for the diseases to get worse, and outcomes, suggests a comprehensive analysis by scientists at the National Institutes of Health and George Washington University Medical Center, Washington, D.C. Findings were published July 3 in the New England Journal of Medicine.
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Research Update
Levels of a protein in the blood can help predict whether kidney function will deteriorate in people with high-risk genetic variants of the gene APOL1.
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News Release
A study funded by the NIH created the most comprehensive atlas of the human kidney to advance progress in understanding and treating kidney disease. The Kidney Tissue Atlas marks an important milestone for the multicenter study, called the Kidney Precision Medicine Project (KPMP), which began in 2017 with the aim of improving treatment for kidney disease.
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Research Update
Streaming fluid across engineered aggregations of kidney cells in the lab can dramatically improve the extent to which they replicate normal kidney functions.
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Research Update
A design change to the lithotripter, a machine that creates shock waves that break up kidney stones, helps to decrease tissue damage and increase effectiveness.
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Research Update
Helium ion scanning microscopy, an innovation in imaging, was used to take the most detailed pictures of the glomerulus and other kidney structures to date.
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Research Update
Scientists have developed new ultrasonic propulsion technology that can reposition kidney stones and help with stone fragment passage in people.
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Research Update
African Americans with APOL1 gene experience faster rate of decline in kidney function and begin hemodialysis at a younger age versus those without the gene.
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Research Update
NKDEP working group sets goals to improve electronic health records and standardize their use, helping improve care for people with chronic kidney diseases.
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Research Update
Researchers found six new regions in the human genome that increase IgAN susceptibility, as well as the risk of developing inflammatory bowel disease.
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Research Update
Genetic testing on African Americans examined their APOL1 gene status as it's related to kidney function and risk of developing cardiovascular disease.
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Research Update
In mice, kidney damage caused by autosomal dominant polycystic kidney disease can largely be reversed by activating the normal version of a faulty gene.
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News Release
Kidney disease can lead to heart disease, and vice versa. And on World Kidney Day, Griffin P. Rodgers, M.D., director of the NIH's National Institute of Diabetes and Digestive and Kidney Diseases asks people to consider the link, and what they can do to protect kidney health. March 10 marks World Kidney Day this year; it's part of National Kidney Month.
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Research Update
Researchers found six new regions in the human genome that increase the risk of immunoglobulin A nephropathy (IgAN) and inflammatory bowel disease.
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Research Update
HLA matching for kidney transplants from deceased donors could enhance long-term survival in the US by delaying or eliminating the need to resume dialysis.
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News Release
More than 20 million Americans aged 20 or older may have chronic kidney disease (CKD) and millions more are at risk of developing the disease.
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News Release
In recognition of World Kidney Day 2014 on March 13, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute on Aging (NIA) at the National Institutes of Health remind older Americans about the importance of protecting their kidneys and urge them to better understand the decline of kidney function as people age.
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Research Update
The protein KIM-1 plays a critical role in progression of diabetic kidney disease and may serve as a promising therapeutic target.
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News Release
In recognition of World Kidney Day on March 8, the NIH is promoting efforts to reduce disparities in organ transplantation. This is particularly important among African-Americans, Hispanics, and American Indians, all of whom are disproportionately affected by kidney failure — yet are less likely to receive organ transplants.
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Research Update
A recently discovered set of gene mutations may be behind some cases of the serious blood disorder hemolytic uremic syndrome (HUS).
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News Release
In observance of World Kidney Day on March 14, the NIH is raising awareness of the long term effects of acute kidney injury (AKI) — a sudden loss of kidney function. Research funded by the NIH’s NIDDK suggests survivors of AKI have a lifelong increased risk for developing permanent kidney damage, resulting in decreased kidney function.
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News Release
Can a high-tech water bottle help reduce the recurrence of kidney stones? What about a financial incentive? Those are questions researchers funded by the National Institutes of Health will seek to answer as they begin recruiting participants for a two-year clinical trial at four sites across the country. Scientists will test whether using a smart water bottle that encourages people to drink more water, and therefore urinate, will reduce the recurrence of urinary stone disease, commonly referred to as kidney stones. The trial is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of NIH.
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News Release
This World Kidney Day, improve your kidney health by making a commitment to reach or maintain a healthy weight. Extra weight increases the risk of developing diabetes and high blood pressure, the two most common causes of chronic kidney disease (CKD). People affected by obesity have an 83 percent higher risk of developing CKD compared to those who have a healthy weight.
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News Release
On World Kidney Day, the NIDDK urges women to adopt healthy lifestyle habits and inspire family and friends to do the same.
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Research Update
In contrast to previous reports, intensive blood pressure control does not lead to kidney injury in people who do not have chronic kidney disease.
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Research Update
A recent report described a previously unknown role of exosomes in progression of polycystic kidney disease and identified a compound capable of delaying cyst growth in mouse models of the disease.
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Research Update
Researchers have observed differences in brain structure in children with chronic kidney disease compared to children without the disease.
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News Release
Controlling blood glucose early in the course of type 1 diabetes yields huge dividends, preserving kidney function for decades. The new finding from a study funded by the NIH was published online in the New England Journal of Medicine Nov. 12 to coincide with presentation at a scientific meeting.
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News Release
In what may lead to a shift in treatment, the largest prospective study of children with chronic kidney disease (CKD) has confirmed some experts' suspicions that complications occur early. The findings suggest the need for earlier, more aggressive management of blood pressure, anemia and other problems associated with kidney disease, according to Dr. Marva Moxey-Mims, a pediatric kidney specialist at the NIH.
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Research Update
Researchers have clarified what genetic variations can cause polycystic kidney disease in people.
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Research Update
Fundamental new insights into kidney development and organization and how they differ between male and female mice could aid research efforts to battle human kidney diseases.
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Research Update
New findings regarding blood vessels in the kidney could have important implications for developing artificial kidney technologies.
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Research Update
Research findings lead to the development of a new class of diabetes drugs that allows the kidneys to dispose of excess blood glucose in the urine.
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News Release
Even with more prescriptions for growth hormone, children and adolescents with chronic kidney disease were less likely to grow to normal height ranges if they came from lower-income families, according to research funded by the National Institutes of Health. Results from the Chronic Kidney Disease in Children (CKiD) Study are published in the December issue of the American Journal of Kidney Diseases.
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News Release
Researchers from the Chronic Renal Insufficiency Cohort (CRIC) study are embarking on another five years of work to identify risk factors for progression of early stage chronic kidney disease (CKD), better understand the importance of reduced kidney function in older persons, and learn what role CKD may play in other illnesses that require hospitalization. CRIC is supported by the National Institutes of Health.
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News Release
A gene variant common in African-Americans predicts that people with that gene who also have chronic kidney disease (CKD) are twice as likely to progress to kidney failure as African-Americans without the high-risk gene and white people with CKD. People with the high-risk gene also tend to lose kidney function at twice the rate of those without the gene, according to the research, which was funded by the National Institutes of Health.
