Renal Imaging Workshop

Event Details

Background

The objective of this workshop is to chart a path forward to functional renal imaging. We plan to cover the state of the art in renal imaging and learn from other fields. Toward future clinical use, we will also hear about FDA qualification of imaging biomarkers and other translational challenges.

Co-Sponsors/Organizers

Bruce Molitoris, Indiana

Lilach Lerman, Mayo

Pottumarthi Prasad, Northshore

Kevin Bennett, Washington University in St. Louis

John Sedor, Cleveland Clinic

Alan Koretsky, NINDS (intramural)

Andrew Arai, NHLBI (intramural)

Shumin Wang, NIBIB

Maren Laughlin, NIDDK

Rob Star, NIDDK

Paul Kimmel, NIDDK

Daniel Gossett, NIDDK

Registration Deadline

July 1, 2018

Agenda

Schedule and all titles are tentative.

July 12, 2018

8:00 a.m. – 8:15 a.m.

Introductions
Robert Star, M.D., NIDDK

8:15 a.m. – 8:45 a.m.

Meeting Charge and Framing Lecture [Presentation (PDF, 1.71 MB) ]
Lilach Lerman, M.D., Ph.D., Mayo Clinic
Bruce Molitoris, M.D., Indiana University

State of the Art in Functional Imaging

(10 min. talk, followed by 10 min. Q&A each)

Goal: Define the state of the art and technologies in the pipeline

8:45 a.m. – 9:05 a.m.

BOLD and Diffusion MRI for Evaluating Renal Oxygenation and Fibrosis [Presentation (PDF, 4.33 MB) ]
Pottumarthi Prasad, Ph.D., Northshore University Health Systems

9:05 a.m. – 9:25 a.m.

Efforts of European Consortium in MRI (Parenchima) [Presentation (PDF, 13.52 MB) ]
Anna Caroli, Ph.D., IRCCS Istituto di Ricerche Farmacologiche Mario Negri

9:25 a.m. – 9:45 a.m.

MR Imaging of Renal Perfusion using ASL [Presentation (PDF, 4.33 MB) ]
Sean Fain, Ph.D., University of Wisconsin-Madison

9:45 a.m. – 10:05 a.m.

CEST and Na-23 MRI Approaches for Assessing Renal Function [Presentation (PDF, 9.42 MB) ]
Robert Lenkinski, Ph.D., University of Texas Southwestern

10:05 a.m. – 10:25 a.m.

Break

Concept to Clinic – Cross-Cutting Issues in Translation

(10 min. talk, followed by 10 min. Q&A each)

10:25 a.m. – 10:45 a.m.

Development and Seeking Regulatory Approval for New Contrast Agents [Presentation (PDF, 1.82 MB) ]
Peter Caravan, Ph.D., Harvard Medical School/Massachusetts General Hospital

10:45 a.m. – 11:05 a.m.

Contrast Toxicity: Contrast Agent Safety with Focus on MRI
Andrew Arai, M.D., National Heart, Lung, and Blood Institute

11:05 a.m. – 11:25 a.m.

How to Turn an Imaging Technology into a Biomarker: Bioinformatics/Machine Learning for Developing New Biomarkers from Imaging Data / CT-MRI
Satish Viswanath, Ph.D., M.Sc., Case Western Reserve University

11:25 p.m. – 11:45 a.m.

FDA Biomarker Qualification and MRI Imaging Parameters qualified by FDA (CRISP Measures) [Presentation (PDF, 161.02 KB) ]
Aliza Thompson, M.D., Center for Drug Evaluation and Research, U.S. Food and Drug Administration
Ronald Perrone, M.D., Tufts Medical Center
Daniel Krainak, Ph.D., Center for Devices and Radiological Health, U.S. Food and Drug Administration

11:45 a.m. – 1:15 p.m.

Lunch and Poster Session

The goals of the Poster Session are to cover technologies and recent studies not adequately covered by the oral presentations and to provide opportunities for junior investigators and trainees.

Fibrosis

(10 min. talk, followed by 10 min. Q&A each)

1:15 p.m. – 1:35 p.m.

New MR Probes to Monitor Active Fibrogenesis (Kidney and More Mature Work in Lung) [Presentation (PDF, 9.04 MB) ]
Peter Caravan, Ph.D., Harvard Medical School/Massachusetts General Hospital

1:35 p.m. – 1:55 p.m.

Magnetization Transfer Imaging (MTI) [Presentation (PDF, 3.37 MB) ]
Lilach Lerman, M.D., Ph.D., Mayo Clinic

1:55 p.m. – 2:15 p.m.

Ultrasound-based Elasticity for Kidney Transplant Measurements
Matthew Urban, Ph.D., Mayo Clinic

2:15 p.m. – 2:35 p.m.

MR Elastography: Development and Introduction into Clinical Practice [Presentation (PDF, 3.92 MB) ]
Jun Chen, Ph.D., Mayo Clinic

2:35 p.m. – 2:55 p.m.

Elastin-based Molecular MRI of Fibrosis (Current Focus on Atherosclerosis/Liver)
Peter Boor, M.D., Ph.D., University Clinic of RWTH Aachen

2:55 p.m. – 3:00 p.m.

Charge to Break-out Groups
Robert Star, M.D., NIDDK

3:00 p.m. – 5:00 p.m.

Breakout Groups

• Accelerating Translation from Animals to Patients
• Functional Imaging
• Using Fibrosis as a Phenotype

5:00 p.m. – 6:00 p.m.

Day 1 Breakout Group Reports

6:00 p.m.

Adjourn

July 13, 2018

Summary: Plenary talks from outside the field, talks focusing on where we are going, and breakout groups on these emerging modalities

(10 min. talk, followed by 10 min. Q&A each, except the Intro and review of progress Day 1 that I would suggest to add, which has no Q&A).

8:00 a.m. – 8:20 a.m.

Selected Abstract: Noninvasive Early Detection and Dynamic Mapping of Liver and Kidney Diseases by Collagen-Targeted Protein MRI Contrast Agent
Jenny Yang, Ph.D., Georgia State University

8:20 a.m. – 8:40 a.m.

Selected Abstract: First Experience with Renal Functional MRI Measurements in a Multicenter Longitudinal Study
Anand Srivastava, M.D., M.P.H., Northwestern University Feinberg School of Medicine

8:40 a.m. – 9:00 a.m.

MR Fingerprinting (Brain)
Dan Ma, Ph.D., Case Western Reserve University

9:00 a.m. – 9:20 a.m.

Imaging for Target Engagement in Oncology [Presentation (PDF, 5.2 MB) ]
Peter Choyke, M.D., FACR, National Cancer Institute

9:20 a.m. – 9:40 a.m.

Cardiac PET
Vasken Dilsizian, M.D., University of Maryland Medical Center

9:40 a.m. – 10:00 a.m.

Break

Where Are We going? Toward Single-Nephron Function And Molecular Imaging

Goals: Highlight questions we have just begun to think answerable

(10 min. talk, followed by 10 min. Q&A each)

10:00 a.m. – 10:20 a.m.

Nephron Number and Function in Disease [Presentation (PDF, 10.28 MB) ]
John Bertram, D.Sc., Monash University

10:20 a.m. – 10:40 a.m.

Cationized Ferritin Nanoparticles to Measure Renal Glomerular Microstructure and Function with MRI (Nephron Endowment, Glomerular Volume, and Single Nephron Filtration)
Kevin Bennett, Ph.D., Washington University in St. Louis

10:40 a.m. – 11:00 a.m.

Single Kidney GFR by MRI in Humans
Kai Jiang, Ph.D., Mayo Clinic

11:00 a.m. – 11:20 a.m.

Quantitative Susceptibility Mapping
Chunlei Liu, University of California, Berkeley

11:20 a.m. – 11:40 a.m.

Molecular Imaging in the Kidney [Presentation (PDF, 1.15 MB) ]
David Vera, Ph.D., University of California, San Diego

11:40 a.m. – 12:40 p.m.

Lunch

12:40 p.m. – 2:10 p.m.

Breakout Groups

• Toward Nephron Endowment and Single-Nephron Function
• Molecular Imaging For Phenotyping and Target Engagement

2:10 p.m. – 3:10 p.m.

Day 2 Breakout Group Reports

3:10 p.m. – 3:25 p.m.

Closing Remarks
Robert Star, M.D., NIDDK

3:25 p.m.

Meeting Adjournment

Abstracts

Abstracts are invited for poster presentations. The top abstract, as judged by the organizing committee, will be invited to present an oral presentation on July 13.

Submission Deadline

Monday, June 18, 2018.

Submitting Abstracts

All abstracts must be submitted via email to Mark Dennis of The Scientific Consulting Group, Inc. Abstract submissions should be no longer than 250 words (not including name and affiliation). Download the Abstract Template (DOCX, 24.67 KB) .

Formatting Requirements

Please follow the instructions below to format an abstract. (Note: Submissions will not be edited for spelling or grammar and will be accepted “as is.”)

• The abstract should be an MS Word document typed single-spaced using Times New Roman font. Everything but the title should be in normal, 12-point font.
  • The abstract’s title should be Bold, 16-Point, Title Case font and should clearly represent the nature of the investigation.
  • On the line after the title, list the author’s first and last names, degree, affiliation, city, state, and country.
  • Separate multiple authors with a semicolon, and underline the primary author’s name (one primary author per abstract).
  • Use one blank line between the title and the body of the abstract and between paragraphs.
  • The abstract file name should follow this format: LastNameofprimary author_FirstWordOfTitle (e.g., Zucker_Effects).
• Please ensure that your abstract is the correct length and use 1-inch margins.
• Use of standard abbreviations is desirable (e.g., LUTS), as well as standard symbols for units of measure (e.g., kg, g, mg, mL, L, and %). Place any special or unusual abbreviations in parentheses after the full word the first time that it appears. Use numerals to indicate numbers except to begin sentences. Do not use subheadings (e.g., Methods, Results).
• Simple tables or graphs may be included; however, they must fit within the designated abstract space of one page.