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The purpose of the workshop is to bring together researchers from multiple areas to discuss the state of the science and to help us understand where the research opportunities are and the roadblocks.
Registration Deadline
April 17, 2018
Agenda
April 23, 2018
8:30 a.m. – 8:40 a.m.
Welcome and Opening Remarks
Session 1: Focus on Disease Mechanism
8:40 a.m. – 9:10 a.m.
Integration of Large-scale Genetic and Genomic Data for Type 2 Diabetes (T2D)
Mark McCarthy, M.D., University of Oxford
9:10 a.m. – 9:40 a.m.
One Variant, Multiple Disease Mechanisms: Dissecting the Association of TCF7L2 with T2D
Marcelo Nobrega, M.D., Ph.D., The University of Chicago
9:40 a.m. – 10:10 a.m.
Functional Noncoding Variants and Genes at Insulin Resistance Loci
Karen Mohlke, Ph.D., The University of North Carolina at Chapel Hill
10:10 a.m. – 10:30 a m
Break
Session 2: Focus on Regulatory Variants
10:30 a.m. – 11:00 a.m.
Illuminating Genome-wide Association Study (GWAS) Variants Using Functional Footprinting
John Stamatoyannopoulos, M.D., University of Washington
11:00 a.m. – 11:30 a.m.
Insights into the Role of Regulatory Genetic Variants from Understanding Diversity in the Immune Response
Julian Knight, D.Phil., M.B.Ch.B., University of Oxford
11:30 a.m. – 12:00 p.m.
Functional Interrogation of Common Genetic Variation Uncovers Regulators of Hematopoiesis and Therapeutic Targets
Vijay Sankaran, M.D., Ph.D., Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
12:00 p.m. – 12:30 p.m.
Dissecting the Function of Gene Regulation Using Massively Parallel Reporter Assays
Eran Segal, Ph.D., Weizmann Institute of Science
Session 3: Working Lunch and Portals/Resources Presentations
12:30 p.m. – 1:00 p.m.
Break and Lunch Distribution
1:00 p.m. – 1:15 p.m.
Demonstration of the T2D Knowledge Portal
Jason Flannick, Ph.D., M.S., Broad Institute of MIT and Harvard
Noël Burtt, Broad Institute of MIT and Harvard
1:15 p.m. – 1:30 p.m.
Demonstration of the T2D Dream
Kyle Gaulton, Ph.D., University of California, San Diego
1:30 p.m. – 1:45 p.m.
Break
Session 4: Connecting Variants to Genes
1:45 p.m. – 2:15 p.m.
Connecting Noncoding Variants to Target Genes
Bing Ren, Ph.D., University of California, San Diego
2:15 p.m. – 2:45 p.m.
Contribution of Cis-regulatory DNA to Complex Disease Etiology
Emmanouil Dermitzakis, Ph.D., M.Sc., University of Geneva Medical School
2:45 p.m. – 3:15 p.m.
From Genomics to Therapeutics: Dissecting and Manipulating GWAS Circuitry
Manolis Kellis, Ph.D., M.Eng., Massachusetts Institute of Technology (MIT)
3:15 p.m. – 3:30 p.m.
Break
Session 5: Focus on Networks
3:30 p.m. – 4:00 p.m.
Title TBD
Olga Troyanskaya, Ph.D., Princeton University
4:00 p.m. – 4:30 p.m.
Decoding Patient Genomes through the Hierarchical Pathway Architecture of a Cell
Jason Kreisberg, Ph.D., University of California, San Diego
4:30 p.m. – 5:00 p.m.
Functional Interpretation of Genetic Data in T2D Using Cell-type-specific Protein/Protein Interaction Networks
Kasper Lage Hansen, Ph.D., Harvard University
5:00 p.m. – 5:15 p.m.
Wrap-up
April 24, 2018
Session 6: Functional Genomics
8:30 a.m. – 9:00 a.m.
Genome Editing to Link Regulatory Variants to Disease Phenotypes
Maike Sander, M.D., University of California, San Diego
9:00 a.m. – 9:30 a.m.
Noncoding Genome Function in the Developing and Adult Pancreas
Jorge Ferrer, M.D., Imperial College London
9:30 a.m. – 10:00 a.m.
Diabetes Genetic Regulatory Signatures across Tissues and Species
Stephen Parker, Ph.D., University of Michigan
10:00 a.m. – 10:30 a.m.
Break
Session 7: Model Systems
10:30 a.m. – 11:00 a.m.
Discovery and Validation of Regulatory Variation with Human Pluripotent Stem Cells
Kiran Musunuru, M.D., Ph.D., M.P.H., University of Pennsylvania
11:00 a.m. – 11:30 a.m.
Fishing for Function: Zebrafish Models for Interpretation of Syndromic and Common Diabetes Genetics
Norann Zaghloul, Ph.D., University of Maryland School of Medicine
11:30 a.m. – 12:00 p.m.
Diabetes Genetics in the Diversity Outbred Mouse Population
Alan Attie, Ph.D., University of Wisconsin-Madison
Session 8: Discussion of Next Steps
12:00 p.m. – 12:15 p.m.
Charge to the Groups
Manolis Kellis, Ph.D., M.Eng., MIT
Mark McCarthy, M.D., University of Oxford
12:15 p.m. – 1:45 p.m.
Lunch and Breakout Discussions
Session 9: Focus on T2D
1:45 p.m. – 2:15 p.m.
Deconstructing Diabetes Genetics with Pancreatic Islets and Fruit Flies
Seung Kim, M.D., Ph.D., Stanford University
2:15 p.m. – 2:45 p.m.
Functional Characterisation of T2D GWAS Loci: Going from One to Many
Anna Gloyn, D.Phil., University of Oxford
2:45 p.m. – 3:15 p.m.
Genomic Expression Signatures of Glycemic Traits
Ines Barroso, Ph.D., The Wellcome Sanger Institute
Session 10: Discussion Report-backs and Wrap-up
3:15 p.m. – 4:15 p.m.
Report-backs
4:15 p.m. – 4:30 p.m.
Wrap-up
4:30 p.m.
Adjournment
Event Logistics
Registration
Registration Closed
Registration ended
Location
Lister Hill Auditorium National Library of Medicine 8600 Rockville Pike NIH Building 38A Bethesda,MD20894
