Frequently Asked Questions: KPMP Central Hub

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  1. How many pages is a Central Hub application?
  2. Can a single institution submit multiple applications for the Central Hub?
  3. Are foreign institutions allowed to apply for the Central Hub?
  4. What is the U2C mechanism?
  5. Is the U2C a phased mechanism?
  6. How much should the Central Hub request for shipping of samples?
  7. How much can the Central Hub request for the KPMP Opportunity Pool?
  8. What is the role of the Central Hub in tissue interrogation?
  9. Whom should I contact if I have other questions about the Central Hub?

How many pages is a Central Hub application?

The Central Hub is a multi-component application. The Research Strategy section should be 36 pages total and divided into the following sections:

  • Overall = 6 pages
  • Data and sample Coordinating Center = 12 pages
  • Data Visualization Center = 12 pages
  • Admin Core = 6 pages

Can a single institution submit multiple applications for the Central Hub?

No. A single institution cannot submit multiple applications for the Central Hub. However, in addition to submitting one application for the Central Hub, a single institution may submit multiple applications for Recruitment Sites and/or Tissue Interrogation Sites, assuming no scientific or budgetary overlap.

Are foreign institutions allowed to apply for the Central Hub?

No. Foreign institutions are not allowed to apply for the Central Hub. However, the Central Hub includes three different components (the Data and sample Coordinating Center, the Data Visualization Center, and the Administrative Core). A Central Hub application from a domestic institution may contain a foreign component (i.e., a subcontract to a foreign institution) if it offers unique expertise or resources that are not currently available in the United States.

What is the U2C mechanism?

The U2C is a multi-component award that aims to maximize the use of resources by the research community. The U2C will be used to support the KPMP Central Hub.

The U2C is a cooperative agreement. This is different than a standard R01 grant and means that there will be substantial scientific and programmatic involvement by the NIDDK. Substantial involvement means that, after the award is made, the NIDDK will assist, guide, coordinate, or participate in all activities.

Is the U2C a phased mechanism?

No. It is anticipated that the Central Hub will be a single 5-year award.

How much should the Central Hub budget for shipping of samples?

The Central Hub will pay for shipping and handling of all data and samples (including biopsies, blood, urine, tissue blocks, pathology slides, etc.) to and from the Recruitment Sites and Tissue Interrogation Sites. It is expected that these costs will total $15,000 per year.

How much can the Central Hub request for the KPMP Opportunity Pool?

Applicants can ask for $1,000,000 or more per year for the Opportunity Pool. In addition, applicants should budget for costs associated with the administration of the Opportunity Pool. It is anticipated that the Opportunity Pool will support about 5 pilot/partnership studies per year (with each award being about $200,000 total costs). Do not propose topics for the Opportunity Pool Program.

Excluding the Opportunity Pool, the direct costs for the Central Hub are expected to be approximately $1,700,000 per year.

The KPMP Opportunity Pool Program will:

  • Continually monitor the scientific, infrastructure and resource needs of the KPMP.
  • Develop requests for applications, manage acceptance and organize external peer-review.
  • Establish an administrative structure to select projects for funding, disburse and track awards.
  • Establish procedures, formats and timelines, for monitoring and reporting, progress and outcomes (e.g., publications, subsequent awards).

What is the role of the Central Hub in tissue interrogation?

 The Central Hub will coordinate the activities for the KPMP, but is not responsible for conducting its own molecular analysis.

Whom should I contact if I have other questions about the Central Hub?

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