Kidney Precision Medicine Project
Identifying critical human cells, pathways, and targets for new therapies in acute and chronic kidney diseases.
The NIDDK Kidney Precision Medicine Project (KPMP) aims to ethically obtain and evaluate human kidney biopsies from participants with Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD), create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies. The project will have three distinct, but highly interactive activities: Recruitment Sites, Tissues Interrogation Sites, and Central Hub. Additional technology development in support of the KPMP will be supported by small business programs.
KPMP Activities
View detailed KPMP Activities (PDF, 121 KB).
Recruitment Sites (RS)
Funding opportunity announcement number RFA-DK-16-026
Objective
Recruit either Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD) patients for longitudinal cohort studies with research kidney biopsies.
Total Funds Available
Approximately $1.6 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 4 awards
Funding Mechanism
UG3/UH3
- UG3 phase (2yrs) to establish common protocols and enroll small numbers of patients
- UH3 phase (3yrs) to expand longitudinal cohort studies in initial AKI or CKD populations
Research Strategy Page Limit
12 pages total covering both the UG3 and UH3 phases
Staff Contacts
- Paul Kimmel - AKI and CKD
- Chris Ketchum - General KPMP
More Information
Tissue Interrogation Sites (TIS)
Funding opportunity announcement number RFA-DK-16-027
Objective
Support agnostic discovery on human kidney tissue
Total Funds Available
Approximately $2.0 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 5 awards
Funding Mechanism
UG3/UH3
- UG3 phase (2yrs) to use or adapt current “state-of-the-art” methods to interrogate existing samples and small numbers of biopsies; to develop and optimize “next generation” tissue interrogation methods
- UH3 phase (3yrs) to implement next generation interrogation methods
Research Strategy Page Limit
12 pages total covering both the UG3 and UH3 phases
Staff Contacts
- Krystyna Rys-Sikora - Tissue interrogation
- Daniel Gossett - Tool and technology development
- Chris Ketchum - General KPMP
More Information
Central Hub (CH)
Funding opportunity announcement number RFA-DK-16-028
Objective
Aggregate, analyze and visualize all participant data and samples and provide scientific, infrastructure and administrative support for the entire KPMP.
Total Funds Available
Approximately $3.15 million total costs per year for 5 years
Anticipated Number of Sites
One multicomponent award
Funding Mechanism
U2C
Central Hub Components
Data and Sample Coordinating Center (DCC)
- Supports clinical protocol development and statistical calculations
- Performs standard clinical assessments (e.g., patient data reports, recruitment tables)
- Collects, curates, aggregates, stores, distributes, and ensures quality control of all data and samples
Data Visualization Center (DVC)
- Perform digital pathology
- Create a kidney tissue atlas to classify and locate different cell types and interstitial components in health and disease
- Develop and manage a website for internal and external communication, analysis, and discovery
Administrative Core (AC)
- Provide administrative and meeting support
- Establish working groups
- Solicit patient input and feedback
- Administer an opportunity pool to form new partnerships
Research Strategy Page Limit
36 pages total, divided across the following components:
- Overall = 6 pages
- Data and sample Coordinating Center = 12 pages
- Data Visualization Center = 12 pages
- Admin Core = 6 pages
Staff Contacts
- Tracy Rankin - Administrative Core or Data and Sample Coordinating Center
- Deborah Hoshizaki - Data Visualization Center
- Chris Ketchum - General KPMP
More Information
Technology Development and Validation by Small Businesses
Related Links
-
2016
-
2015
-
2014
-
View related clinical trials from ClinicalTrials.gov.
-
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.
Research Resources
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
Research Training
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training ProgramsDiversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity ProgramsSmall Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.
Learn about NIDDK Small Business ProgramsHuman Subjects Research
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects ResearchTranslational Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.
Learn about NIDDK Translational Research OpportunitiesMeetings & Workshops
-
NIH Common Fund
Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
-
Planning to Apply? Register Early
Registration is required at eRA Commons and grants.gov and can take 4 weeks.