Kidney Precision Medicine Project
Identifying critical human cells, pathways, and targets for new therapies in acute and chronic kidney diseases.
The NIDDK Kidney Precision Medicine Project (KPMP) aims to ethically obtain and evaluate human kidney biopsies from participants with Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD), create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies. The project will have three distinct, but highly interactive activities: Recruitment Sites, Tissues Interrogation Sites, and Central Hub. Additional technology development in support of the KPMP will be supported by small business programs.
KPMP Activities
View detailed KPMP Activities (PDF, 121 KB).
Recruitment Sites (RS)
Funding opportunity announcement number RFA-DK-16-026
Objective
Recruit either Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD) patients for longitudinal cohort studies with research kidney biopsies.
Total Funds Available
Approximately $1.6 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 4 awards
Funding Mechanism
UG3/UH3
- UG3 phase (2yrs) to establish common protocols and enroll small numbers of patients
- UH3 phase (3yrs) to expand longitudinal cohort studies in initial AKI or CKD populations
Research Strategy Page Limit
12 pages total covering both the UG3 and UH3 phases
Staff Contacts
- Paul Kimmel - AKI and CKD
- Chris Ketchum - General KPMP
More Information
Tissue Interrogation Sites (TIS)
Funding opportunity announcement number RFA-DK-16-027
Objective
Support agnostic discovery on human kidney tissue
Total Funds Available
Approximately $2.0 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 5 awards
Funding Mechanism
UG3/UH3
- UG3 phase (2yrs) to use or adapt current “state-of-the-art” methods to interrogate existing samples and small numbers of biopsies; to develop and optimize “next generation” tissue interrogation methods
- UH3 phase (3yrs) to implement next generation interrogation methods
Research Strategy Page Limit
12 pages total covering both the UG3 and UH3 phases
Staff Contacts
- Tool and technology development- Daniel Gossett, 301-594-7723
- Peer-review- Jason Hoffert, 301-496-9010
- Budget or grants management- Carolyn Kofa-Sullivan, 301-594-7687
More Information
Central Hub (CH)
Funding opportunity announcement number RFA-DK-16-028
Objective
Aggregate, analyze and visualize all participant data and samples and provide scientific, infrastructure and administrative support for the entire KPMP.
Total Funds Available
Approximately $3.15 million total costs per year for 5 years
Anticipated Number of Sites
One multicomponent award
Funding Mechanism
U2C
Central Hub Components
Data and Sample Coordinating Center (DCC)
- Supports clinical protocol development and statistical calculations
- Performs standard clinical assessments (e.g., patient data reports, recruitment tables)
- Collects, curates, aggregates, stores, distributes, and ensures quality control of all data and samples
Data Visualization Center (DVC)
- Perform digital pathology
- Create a kidney tissue atlas to classify and locate different cell types and interstitial components in health and disease
- Develop and manage a website for internal and external communication, analysis, and discovery
Administrative Core (AC)
- Provide administrative and meeting support
- Establish working groups
- Solicit patient input and feedback
- Administer an opportunity pool to form new partnerships
Research Strategy Page Limit
36 pages total, divided across the following components:
- Overall = 6 pages
- Data and sample Coordinating Center = 12 pages
- Data Visualization Center = 12 pages
- Admin Core = 6 pages
Staff Contacts
- Tracy Rankin - Administrative Core or Data and Sample Coordinating Center
- Deborah Hoshizaki - Data Visualization Center
- Chris Ketchum - General KPMP
More Information
Technology Development and Validation by Small Businesses
Related Links
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2014
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