Kidney Precision Medicine Project
Identifying critical human cells, pathways, and targets for new therapies in acute and chronic kidney diseases.
The NIDDK Kidney Precision Medicine Project (KPMP) aims to ethically obtain and evaluate human kidney biopsies from participants with Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD), create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies. The project will have four distinct, but highly interactive activities: Recruitment Sites, Tissues Interrogation Sites, a Central Hub and a Kidney Tissue Atlas Coordinating Center. Additional technology development in support of the KPMP will be supported by small business programs.
KPMP Activities
View detailed KPMP Structure and Stages (PDF, 503.86 KB) .
Recruitment Sites (RS)
Funding opportunity announcement number RFA-DK-20-026
Objective
Enroll adults with AKI and/or CKD from varied age, sex, racial, ethnic, socioeconomic, and geographic backgrounds into a longitudinal cohort study that includes a research kidney biopsy.
Total Funds Available
Approximately $3.7 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 7 awards
Funding Mechanism
U01
Research Strategy Page Limit
12 pages
Staff Contacts
- Paul Kimmel - AKI
- Afshin Parsa - CKD
- Chris Ketchum - General KPMP
More Information
Tissue Interrogation Sites (TIS)
Funding opportunity announcement number RFA-DK-20-028
Objective
Use and develop innovative technologies to analyze human kidney tissue.
Total Funds Available
Approximately $5 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 8 awards
Funding Mechanism
U01
Research Strategy Page Limit
12 pages
Staff Contacts
More Information
Central Hub (CH)
Funding opportunity announcement number RFA-DK-20-029
Objective
Collect and de-identify all clinical and social risk data and samples, and provide quality control, project management, and administrative support for the entire KPMP.
Total Funds Available
Approximately $4 million total costs per year for 5 years
Anticipated Number of Sites
One award
Funding Mechanism
U24
Research Strategy Page Limit
24 pages
Staff Contacts
- Tracy Rankin
- Ivonne Schulman
- Chris Ketchum - General KPMP
More Information
Kidney Tissue Atlas Coordinating Center (KTACC)
Funding opportunity announcement number RFA-DK-20-027
Objective
Clean, harmonize, store and curate all de-identified KPMP data, perform integrative analyses, and create an interactive Kidney Tissue Atlas.
Total Funds Available
Approximately $2 million total costs per year
Anticipated Number of Sites
One award
Funding Mechanism
U01
Research Strategy Page Limit
12 pages
Staff Contacts
- Eric Brunskill
- Chris Ketchum - General KPMP
More Information
Technology Development and Validation by Small Businesses
Notice of Special Interest: NOT-DK-21-007
Objective
This NOSI intends to encourage small businesses to translate kidney precision medicine discoveries and technologies.
Funding Mechanisms
R41/R42 (STTR) and R43/R44 (SBIR)
Staff Contact
More Information
Related Links
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2016
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2015
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2014
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NIDDK carries forward the activities developed under NKDEP to meet ongoing need.
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View related clinical trials from ClinicalTrials.gov.
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Research Resources
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Additional Research Programs
Research Training
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.
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Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
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Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.
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Human Subjects Research
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NIH Common Fund
Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
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