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Kidney Precision Medicine Project

Identifying critical human cells, pathways, and targets for new therapies in acute and chronic kidney diseases.

The NIDDK Kidney Precision Medicine Project (KPMP) aims to ethically obtain and evaluate human kidney biopsies from participants with Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD), create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies. The project will have three distinct, but highly interactive activities: Recruitment Sites, Tissues Interrogation Sites, and Central Hub. Additional technology development in support of the KPMP will be supported by small business programs.

KPMP Activities

Recruitment sites and tissue interrogation sites separately feed into the central hub. The central hub feeds back into both.

View detailed KPMP Activities (PDF, 121 KB).

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Funding opportunity announcement number RFA-DK-16-026

Objective

Recruit either Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD) patients for longitudinal cohort studies with research kidney biopsies.

Total Funds Available

Approximately $1.6 million total costs per year for 5 years

Anticipated Number of Sites

Approximately 4 awards

Funding Mechanism

UG3/UH3

  • UG3 phase (2yrs) to establish common protocols and enroll small numbers of patients
  • UH3 phase (3yrs) to expand longitudinal cohort studies in initial AKI or CKD populations

Research Strategy Page Limit

12 pages total covering both the UG3 and UH3 phases

Staff Contacts

More Information

Funding opportunity announcement number RFA-DK-16-027

Objective

Support agnostic discovery on human kidney tissue

Total Funds Available

Approximately $2.0 million total costs per year for 5 years

Anticipated Number of Sites

Approximately 5 awards

Funding Mechanism

UG3/UH3

  • UG3 phase (2yrs) to use or adapt current “state-of-the-art” methods to interrogate existing samples and small numbers of biopsies; to develop and optimize “next generation” tissue interrogation methods
  • UH3 phase (3yrs) to implement next generation interrogation methods

Research Strategy Page Limit

12 pages total covering both the UG3 and UH3 phases

Staff Contacts

More Information

Funding opportunity announcement number RFA-DK-16-028

Objective

Aggregate, analyze and visualize all participant data and samples and provide scientific, infrastructure and administrative support for the entire KPMP.

Total Funds Available

Approximately $3.15 million total costs per year for 5 years

Anticipated Number of Sites

One multicomponent award

Funding Mechanism

U2C

Central Hub Components

Data and Sample Coordinating Center (DCC)
  • Supports clinical protocol development and statistical calculations
  • Performs standard clinical assessments (e.g., patient data reports, recruitment tables)
  • Collects, curates, aggregates, stores, distributes, and ensures quality control of all data and samples
Data Visualization Center (DVC)
  • Perform digital pathology
  • Create a kidney tissue atlas to classify and locate different cell types and interstitial components in health and disease
  • Develop and manage a website for internal and external communication, analysis, and discovery
Administrative Core (AC)
  • Provide administrative and meeting support
  • Establish working groups
  • Solicit patient input and feedback
  • Administer an opportunity pool to form new partnerships

Research Strategy Page Limit

36 pages total, divided across the following components:

  • Overall = 6 pages
  • Data and sample Coordinating Center = 12 pages
  • Data Visualization Center = 12 pages
  • Admin Core = 6 pages

Staff Contacts

More Information

Funding opportunity announcement numbers PA-16-451 and PA-16-452

Objective

Address the technological needs of the KPMP, from safer biopsy techniques to enhanced tissue interrogation of human kidney tissue.

Funding Mechanisms

R41/R42 (STTR) and R43/R44 (SBIR)

Staff Contact

Daniel Gossett

More Information

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