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  5. Dendrimer Conjugates of Agonists and Antagonists of the GPCR Superfamily (U.S. Patent Number 8,153,781)

Dendrimer Conjugates of Agonists and Antagonists of the GPCR Superfamily (U.S. Patent Number 8,153,781)

Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A1 adenosine receptor agonist having a purine nucleoside moiety and a functional group at the N6 position of the purine nucleoside moiety, wherein the functional group has the formula (I):
N6H-Ar1-CH2-C(??O)NH-R1 (I), wherein Ar1 and R1 as defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.

Resource Details

http://www.google.com/patents/US8153781

tao@niddk.nih.gov

Jacobson, Kenneth

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