Dendrimer Conjugates of Agonists & Antagonists of the GPCR Superfamily (U.S. Patent Number 8,153,781)

Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A₁ adenosine receptor agonist having a purine nucleoside moiety and a functional group at the N⁶ position of the purine nucleoside moiety, wherein the functional group has the formula (I):
N⁶H-Ar¹-CH₂-C(═O)NH-R¹ (I), wherein Ar¹ and R¹ as defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.