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  5. Dendrimer Conjugates of Agonists & Antagonists of the GPCR Superfamily (U.S. Patent Number 8,153,781)

Dendrimer Conjugates of Agonists & Antagonists of the GPCR Superfamily (U.S. Patent Number 8,153,781)

Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A1 adenosine receptor agonist having a purine nucleoside moiety and a functional group at the N6 position of the purine nucleoside moiety, wherein the functional group has the formula (I):
N6H-Ar1-CH2-C(??O)NH-R1 (I), wherein Ar1 and R1 as defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.

Resource Details

http://www.google.com/patents/US8153781

tao@niddk.nih.gov

Jacobson, Kenneth

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Last Reviewed February 2023