Comprehensive Assessment of Renal function (COAR)

May 2022 Council

Lead Division/Office


Point(s) of Contact

Afshin Parsa, M.D., M.P.H.; Ivonne Schulman, M.D.; Deepak Nihalani, Ph.D.; Daniel Gossett, Ph.D.

Executive Summary

Modern medicine lacks reliable tools, methods, and procedures for comprehensive and dynamic assessment of renal function that is inadequately captured by the GFR estimation, is inclusive of all renal compartment specific functions, and accurately measures diverse states, physiologic processes, and disease pathologies. This has significantly limited our ability to adequately determine clinical phenotype in individuals with acute or chronic kidney disease. Consequently, we are mostly unable to match clinical measures of renal function to underlying disease processes, which is limiting progress in both research and clinical practice. Accordingly, the overarching goal of this initiative will be to establish a reliable and comprehensive set of renal function measurement approaches and tools that accurately assess the entirety of renal functional state, reserve, and trajectory, and is optimized to diverse clinical conditions.