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Olivier Blondel, Ph.D.

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Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease

Responsibilities & Activities

My primary interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, chemical biology, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy and single-cell analysis. My portfolio is composed of grants that combine two or more of the areas and technologies described above, and cannot easily be assigned to other portfolios within the Division of Diabetes, Endocrinology, and Metabolic Diseases.

Besides the management of a grant portfolio, my administrative responsibilities include: Project Scientist, Beta Cell Biology Consortium (BCBC); Project Scientist, Human Islet Research Network (HIRN); NIDDK representative, Network for Pancreatic Organ Donors (nPOD); Program Director, Accelerating Medicines Partnership for Type-2 Diabetes (AMP-T2D) Consortium; Coordinator, 4D Nucleome Common Fund Program.

Research Programs

Endocrine Pancreas
Biology, development, and function of the endocrine pancreas and clinical studies on islet transplantation for type 1 diabetes treatment.

Pathophysiology of Diabetes & Metabolic Disease
Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.