Biology, development, and function of the endocrine pancreas and clinical studies on islet transplantation for type 1 diabetes treatment.
The Endocrine Pancreas program supports research on the basic biology, development, and function of the endocrine pancreas, as well as clinical studies on islet transplantation for the treatment of type 1 diabetes. The research in this program includes developmental biology studies on tissue formation, particularly the development and regeneration of pancreatic islets, and basic biology studies on hormone synthesis and secretion from pancreatic endocrine cells (alpha, beta, delta, etc.) within the islet. Areas addressing islet transplantation include studies on optimizing islet yield, viability, and durability in the procurement and pre-transplant process; enhancing islet graft survival and promoting immune tolerance of islet grafts; and evaluating transplantation alternatives to human islets.
NIDDK Program Staff
- Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
- Olivier Blondel, Ph.D. Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease
- Thomas Eggerman, M.D., Ph.D. Cystic fibrosis research and translation centers, Cystic Fibrosis basic research and clinical trials, rare metabolic diseases basic and clinical trials, clinical islet transplantation registry; advanced artificial pancreas clinical trials, post COVID-19 new onset diabetes
- Albert J. Hwa, Ph.D. Basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease; generation of islet cells from stem cells for disease modeling and regenerative medicine; microphysiological systems for diabetes modeling
- Xujing Wang, Ph.D. Data science; computation modeling; integrative genomics; network biology; genotype-phenotype relationship
Recent Funding OpportunitiesView More Recent Funding Opportunities
Cardiovascular Repository Type 1 Diabetes (CARE-T1D) Consortium (U01 Clinical Trial Not Allowed).
Addressing the Impact of Syndemics on the Health of People with HIV and Diseases and Conditions within the Missions of NIDDK and NHLBI (R01 Clinical Trial Optional)
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
Single Source for continuation of the Human Pancreas Analysis Program for Type-2 Diabetes (HPAP-T2D) (U01 Clinical Trial Not Allowed)
Down Syndrome Clinical Cohort Coordinating Center (DS-4C) for the INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) (U54 Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
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