Biology, development, and function of the endocrine pancreas and clinical studies on islet transplantation for type 1 diabetes treatment.
The Endocrine Pancreas program supports research on the basic biology, development, and function of the endocrine pancreas, as well as clinical studies on islet transplantation for the treatment of type 1 diabetes. The research in this program includes developmental biology studies on tissue formation, particularly the development and regeneration of pancreatic islets, and basic biology studies on hormone synthesis and secretion from pancreatic endocrine cells (alpha, beta, delta, etc.) within the islet. Areas addressing islet transplantation include studies on optimizing islet yield, viability, and durability in the procurement and pre-transplant process; enhancing islet graft survival and promoting immune tolerance of islet grafts; and evaluating transplantation alternatives to human islets.
NIDDK Program Staff
- Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
- Olivier Blondel, Ph.D. Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease
- Sheryl Sato, Ph.D. Basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease
- Thomas Eggerman, M.D., Ph.D. Cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation
- Xujing Wang, Ph.D. Data science; computation modeling; integrative genomics; network biology; genotype-phenotype relationship
Recent Funding OpportunitiesView More Recent Funding Opportunities
Limited Competition for Continuation of the Integrated Islet Distribution Program (U24 Clinical Trial Not Allowed)
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Toward ElucidAting MechanismS Contributing to HIV Reservoirs in NIDDK-relevant Tissues (Cure TEAMS) (R01 Clinical Trial Optional)
Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)
Emergency Awards: RADx-rad Data Coordination Center (DCC) (U24 Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
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