Biology, development, and function of the endocrine pancreas and clinical studies on islet transplantation for type 1 diabetes treatment.
The Endocrine Pancreas program supports research on the basic biology, development, and function of the endocrine pancreas, as well as clinical studies on islet transplantation for the treatment of type 1 diabetes. The research in this program includes developmental biology studies on tissue formation, particularly the development and regeneration of pancreatic islets, and basic biology studies on hormone synthesis and secretion from pancreatic endocrine cells (alpha, beta, delta, etc.) within the islet. Areas addressing islet transplantation include studies on optimizing islet yield, viability, and durability in the procurement and pre-transplant process; enhancing islet graft survival and promoting immune tolerance of islet grafts; and evaluating transplantation alternatives to human islets.
NIDDK Program Staff
- Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
- Olivier Blondel, Ph.D. Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease
- Thomas Eggerman, M.D., Ph.D. Cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation; inborn errors of metabolism
- Sheryl Sato, Ph.D. Basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease
- Xujing Wang, Ph.D. Data science; computation modeling; integrative genomics; network biology; genotype-phenotype relationship
Recent Funding OpportunitiesView More Recent Funding Opportunities
Diabetes Research Centers (P30 Clinical Trial Optional)
HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
Advancing Gender Inclusive Excellence (AGIE) Coordinating Center (U54 Clinical Trial Not Allowed)
Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional)
Limited Competition for the Data Coordinating Center (DCC) for the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24 Clinical Trial Optional)
View related clinical trials from ClinicalTrials.gov.
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Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
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Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
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