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NIH: National Institute of Diabetes and Digestive and Kidney Diseases NIH: National Institute of Diabetes and Digestive and Kidney Diseases 75 years: 1950-2025 75 years: 1950-2025
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  4. Pathophysiology of Diabetes & Metabolic Disease

Pathophysiology of Diabetes & Metabolic Disease

Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.

NIDDK Program Staff

  • Kristin M. Abraham, Ph.D. Development of resources and infrastructure to support provision and exploration of human tissues for studies of diabetes, and improvements in innovative mouse models to advance diabetes research.
  • Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
  • Rajatava Basu, Ph.D. Role of immune system in the pathophysiology of Type 2 Diabetes and diabetes-associated metabolic dysfunction, including the role of chronic & meta-inflammation, microbiome-immune-metabolic crosstalk and neuroinflammation
  • Olivier Blondel, Ph.D. Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic disease
  • Miranda Broadney, M.D., M.P.H. Pediatrics, Pediatric Endocrinology, Clinical Management of Diabetes Mellitus, Insulin Resistance, Pediatric Obesity
  • Maren Laughlin, Ph.D. Energy balance, thermogenesis and mitochondria biology, lipid metabolism, and functional and metabolic imaging in adipose, pancreas and other metabolic organs.
  • Hanyu Liang, M.D., Ph.D. Hepatic Metabolism; Insulin Resistance; Type 2 Diabetes; Obesity; Bariatric Surgery
  • Barbara Linder, M.D., Ph.D. Type 2 diabetes in children and youth; human studies of metabolic imprinting
  • Corinne M. Silva, Ph.D. Circadian rhythms, Metabolic Signaling Pathways, Clock Protein Role in Gene Expression, Diabetes, Obesity

Recent Funding Opportunities

View More Recent Funding Opportunities
  1. PAR-25-090

    NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional)

    Summary
  2. PAR-25-091

    Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)

    Summary
  3. PAR-25-312

    Time-Sensitive Evaluation of Policies Affecting Health Behaviors and Chronic Disease Risk (R01-Clinical Trial Not Allowed)

    Summary
  4. PAS-25-073

    Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)

    Summary
  5. PAS-25-102

    Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required)

    Summary
View More Recent Funding Opportunities

Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

  • Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
  • NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
  • NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.

Additional Research Programs

Research Training

Funding Eligibility by Career Level arrow graphic

NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.

Learn about NIDDK Research Training Programs

Small Business

Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.

Learn about NIDDK Small Business Programs

Human Subjects Research

Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.

Learn about Human Subjects Research

Translational Research

Translational Research process graphic

NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.

Learn about NIDDK Translational Research Opportunities

Meetings & Workshops

Leveraging Real-World Evidence Rotator
Leveraging Real-World Evidence to Assess Benefits and Risks of GLP-1-Based Therapies

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Webinar

K Awardees Workshop Rotator
2025 NIDDK K Awardees Workshop

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North Bethesda, MD

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dkNET

Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.

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View all Meetings & Workshops

View all Meetings & Workshops
  • NIH Common Fund

    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.

  • Planning to Apply? Register Early

    Registration is required at eRA Commons and grants.gov and can take 4 weeks.

Last Reviewed October 2024