Oksana Gavrilova, Ph.D.

Director: Mouse Metabolism Core, Cores and Support Services

Scientific Focus Areas: Genetics and Genomics, Health Disparities, Neuroscience, Social and Behavioral Sciences

oksanag@bdg10.niddk.nih.gov 301-435-5370 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

Adipocyte G_i signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity.

Wang L, Pydi SP, Zhu L, Barella LF, Cui Y, Gavrilova O, Bence KK, Vernochet C, Wess J.

Nat Commun (2020 Jun 12) 11:2995. Abstract/Full Text

β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia.

Pydi SP, Jain S, Barella LF, Zhu L, Sakamoto W, Meister J, Wang L, Lu H, Cui Y, Gavrilova O, Wess J.

Sci Adv (2020 Jun) 6:eaba1733. Abstract/Full Text

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion.

Fulgenzi G, Hong Z, Tomassoni-Ardori F, Barella LF, Becker J, Barrick C, Swing D, Yanpallewar S, Croix BS, Wess J, Gavrilova O, Tessarollo L.

Nat Commun (2020 Apr 23) 11:1950. Abstract/Full Text

Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point.

Škop V, Guo J, Liu N, Xiao C, Hall KD, Gavrilova O, Reitman ML.

Cell Rep (2020 Apr 14) 31:107501. Abstract/Full Text

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.

Pydi SP, Jain S, Tung W, Cui Y, Zhu L, Sakamoto W, Jain S, Abel BS, Skarulis MC, Liu J, Huynh T, Pacak K, Caron MG, Gavrilova O, Finkel T, Wess J.

Nat Commun (2019 Jul 3) 10:2936. Abstract/Full Text

Physiology and effects of nucleosides in mice lacking all four adenosine receptors.

Xiao C, Liu N, Jacobson KA, Gavrilova O, Reitman ML.

PLoS Biol (2019 Mar) 17:e3000161. Abstract/Full Text

Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.

Piñol RA, Zahler SH, Li C, Saha A, Tan BK, Škop V, Gavrilova O, Xiao C, Krashes MJ, Reitman ML.

Nat Neurosci (2018 Nov) 21:1530-1540. Abstract/Full Text

Activation of adenosine A_2A or A_2B receptors causes hypothermia in mice.

Carlin JL, Jain S, Duroux R, Suresh RR, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML.

Neuropharmacology (2018 Sep 1) 139:268-278. Abstract/Full Text

Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.

Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML.

Am J Physiol Endocrinol Metab (2018 Sep 1) 315:E357-E366. Abstract/Full Text

Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet.

Liu W, Aerbajinai W, Li H, Liu Y, Gavrilova O, Jain S, Rodgers GP.

Endocrinology (2018 Sep 1) 159:3235-3244. Abstract/Full Text

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.

Zhuang L, Jang Y, Park YK, Lee JE, Jain S, Froimchuk E, Broun A, Liu C, Gavrilova O, Ge K.

Nat Commun (2018 May 4) 9:1796. Abstract/Full Text

Corrigendum to "Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism" [Mol Metabol 6 (2017) 1540-1550].

Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML.

Mol Metab (2018 Mar) 9:220. Abstract/Full Text

Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.

Shin H, Ma Y, Chanturiya T, Cao Q, Wang Y, Kadegowda AKG, Jackson R, Rumore D, Xue B, Shi H, Gavrilova O, Yu L.

Cell Metab (2017 Nov 7) 26:764-777.e5. Abstract/Full Text

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab (2017 Oct 3) 26:672-685.e4. Abstract/Full Text

DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.

Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH.

Cell Metab (2017 Aug 1) 26:447. Abstract/Full Text

DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.

Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH.

Cell Metab (2017 May 2) 25:1135-1146.e7. Abstract/Full Text

Hypothermia in mouse is caused by adenosine A₁ and A₃ receptor agonists and AMP via three distinct mechanisms.

Carlin JL, Jain S, Gizewski E, Wan TC, Tosh DK, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML.

Neuropharmacology (2017 Mar 1) 114:101-113. Abstract/Full Text

Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.

Chen M, Shrestha YB, Podyma B, Cui Z, Naglieri B, Sun H, Ho T, Wilson EA, Li YQ, Gavrilova O, Weinstein LS.

J Clin Invest (2017 Feb 1) 127:500-510. Abstract/Full Text

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

Carlin JL, Tosh DK, Xiao C, Piñol RA, Chen Z, Salvemini D, Gavrilova O, Jacobson KA, Reitman ML.

J Pharmacol Exp Ther (2016 Feb) 356:474-82. Abstract/Full Text

A mouse model for a partially inactive obesity-associated human MC3R variant.

Lee B, Koo J, Yun Jun J, Gavrilova O, Lee Y, Seo AY, Taylor-Douglas DC, Adler-Wailes DC, Chen F, Gardner R, Koutzoumis D, Sherafat Kazemzadeh R, Roberson RB, Yanovski JA.

Nat Commun (2016 Jan 28) 7:10522. Abstract/Full Text

Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight.

Li YQ, Shrestha YB, Chen M, Chanturiya T, Gavrilova O, Weinstein LS.

Proc Natl Acad Sci U S A (2016 Jan 12) 113:446-51. Abstract/Full Text

G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.

Li YQ, Shrestha Y, Pandey M, Chen M, Kablan A, Gavrilova O, Offermanns S, Weinstein LS.

J Clin Invest (2016 Jan) 126:40-9. Abstract/Full Text

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.

Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ.

Nat Commun (2015 Dec 15) 6:10166. Abstract/Full Text

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.

Ma X, Xu L, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E.

Cell Metab (2015 Oct 6) 22:695-708. Abstract/Full Text

Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C.

Xiao C, Goldgof M, Gavrilova O, Reitman ML.

Obesity (Silver Spring) (2015 Jul) 23:1450-9. Abstract/Full Text

Integration of body temperature into the analysis of energy expenditure in the mouse.

Abreu-Vieira G, Xiao C, Gavrilova O, Reitman ML.

Mol Metab (2015 Jun) 4:461-70. Abstract/Full Text

Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice.

Tanaka N, Takahashi S, Matsubara T, Jiang C, Sakamoto W, Chanturiya T, Teng R, Gavrilova O, Gonzalez FJ.

J Biol Chem (2015 Jan 30) 290:3092-105. Abstract/Full Text

Role of forkhead box protein A3 in age-associated metabolic decline.

Ma X, Xu L, Gavrilova O, Mueller E.

Proc Natl Acad Sci U S A (2014 Sep 30) 111:14289-94. Abstract/Full Text

Biphasic effect of melanocortin agonists on metabolic rate and body temperature.

Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML.

Cell Metab (2014 Aug 5) 20:333-45. Abstract/Full Text

The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality.

Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML.

J Biol Chem (2014 Jul 11) 289:19341-50. Abstract/Full Text

Erythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity.

Alnaeeli M, Raaka BM, Gavrilova O, Teng R, Chanturiya T, Noguchi CT.

Diabetes (2014 Jul) 63:2415-31. Abstract/Full Text

Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.

Ravussin Y, Xiao C, Gavrilova O, Reitman ML.

PLoS One (2014) 9:e85876. Abstract/Full Text

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.

Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, Lago CU, Zhang S, DuBois W, Ward T, deCabo R, Gavrilova O, Mock B, Finkel T.

Cell Rep (2013 Sep 12) 4:913-20. Abstract/Full Text

The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.

Xu L, Panel V, Ma X, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E.

Mol Cell Biol (2013 Sep) 33:3392-9. Abstract/Full Text

Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes.

Jiang C, Kim JH, Li F, Qu A, Gavrilova O, Shah YM, Gonzalez FJ.

J Biol Chem (2013 Feb 8) 288:3844-57. Abstract/Full Text

Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy.

Guo T, Bond ND, Jou W, Gavrilova O, Portas J, McPherron AC.

Diabetes (2012 Oct) 61:2414-23. Abstract/Full Text

Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivo.

Ruiz de Azua I, Nakajima K, Rossi M, Cui Y, Jou W, Gavrilova O, Wess J.

FASEB J (2012 Oct) 26:4275-86. Abstract/Full Text

Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic mice.

Lizunov VA, Stenkula KG, Lisinski I, Gavrilova O, Yver DR, Chadt A, Al-Hasani H, Zimmerberg J, Cushman SW.

Am J Physiol Endocrinol Metab (2012 Apr 15) 302:E950-60. Abstract/Full Text

Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis.

Satyanarayana A, Klarmann KD, Gavrilova O, Keller JR.

FASEB J (2012 Jan) 26:309-23. Abstract/Full Text

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.

Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD, Fraser-Liggett C, Matzinger P.

Nat Med (2011 Nov 20) 17:1585-93. Abstract/Full Text

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.

Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX.

J Clin Invest (2011 Nov) 121:4477-90. Abstract/Full Text

Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production.

Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT.

Nat Commun (2011 Nov 1) 2:520. Abstract/Full Text

Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.

Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG.

Cell Metab (2011 Jul 6) 14:67-79. Abstract/Full Text

Beneficial metabolic effects caused by persistent activation of beta-cell M3 muscarinic acetylcholine receptors in transgenic mice.

Gautam D, Ruiz de Azua I, Li JH, Guettier JM, Heard T, Cui Y, Lu H, Jou W, Gavrilova O, Zawalich WS, Wess J.

Endocrinology (2010 Nov) 151:5185-94. Abstract/Full Text

G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis.

Chen M, Chen H, Nguyen A, Gupta D, Wang J, Lai EW, Pacak K, Gavrilova O, Quon MJ, Weinstein LS.

Cell Metab (2010 Apr 7) 11:320-30. Abstract/Full Text

Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.

Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, Gupta D, Lai EW, Pacak K, Gavrilova O, Weinstein LS.

Cell Metab (2009 Jun) 9:548-55. Abstract/Full Text

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency.

Gautam D, Gavrilova O, Jeon J, Pack S, Jou W, Cui Y, Li JH, Wess J.

Cell Metab (2006 Nov) 4:363-75. Abstract/Full Text

Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.

Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML.

J Biol Chem (2003 Sep 5) 278:34268-76. Abstract/Full Text

Leptin and diabetes in lipoatrophic mice.

Gavrilova O, Marcus-Samuels B, Leon LR, Vinson C, Reitman ML.

Nature (2000 Feb 24) 403:850; discussion 850-1. Abstract/Full Text

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.

Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML.

J Clin Invest (2000 Feb) 105:271-8. Abstract/Full Text