Investigating how glial cells sense and respond to cellular stress with the goal of identifying the mechanisms that drive aging and disease.

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Measurements of Physiological Stress Responses in C. Elegans.
Bar-Ziv R, Frakes AE, Higuchi-Sanabria R, Bolas T, Frankino PA, Gildea HK, Metcalf MG, Dillin A.
J Vis Exp (2020 May 21) Abstract/Full Text
Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans.
Frakes AE, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S, Dillin A.
Science (2020 Jan 24) 367:436-440. Abstract/Full Text
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