Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.
Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B.
Nat Immunol (2018 Dec) 19:1403-1414. Abstract/Full Text
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.
Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.
Nat Immunol (2017 Jul) 18:813-823. Abstract/Full Text
Thymic versus induced regulatory T cells - who regulates the regulators?
Povoleri GA, Scottà C, Nova-Lamperti EA, John S, Lombardi G, Afzali B.
Front Immunol (2013) 4:169. Abstract/Full Text
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation.
Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C.
Immunity (2013 Dec 12) 39:1143-57. Abstract/Full Text
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
Kolev M, Dimeloe S, Le Friec G, Navarini A, Arbore G, Povoleri GA, Fischer M, Belle R, Loeliger J, Develioglu L, Bantug GR, Watson J, Couzi L, Afzali B, Lavender P, Hess C, Kemper C.
Immunity (2015 Jun 16) 42:1033-47. Abstract/Full Text

Additional Publications

Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host-Virus Interactions.
Chakravorty S, Yan B, Wang C, Wang L, Quaid JT, Lin CF, Briggs SD, Majumder J, Canaria DA, Chauss D, Chopra G, Olson MR, Zhao B, Afzali B, Kazemian M.
Cancer Res (2019 Sep 3) Abstract/Full Text
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism.
Arbore G, West EE, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, Tunc I, Pavlidis P, Powell N, Li Y, Liu P, Servais A, Couzi L, Fremeaux-Bacchi V, Placais L, Ferraro A, Walsh PR, Kavanagh D, Afzali B, Lavender P, Lachmann HJ, Kemper C.
Nat Commun (2018 Oct 10) 9:4186. Abstract/Full Text
STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.
Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, Uzel G, Lenardo MJ.
J Immunol (2018 Jan 1) 200:110-118. Abstract/Full Text
Unexpected Roles for Intracellular Complement in the Regulation of Th1 Responses.
West EE, Afzali B, Kemper C.
Adv Immunol (2018) 138:35-70. Abstract/Full Text
Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development.
Popat RJ, Hakki S, Thakker A, Coughlan AM, Watson J, Little MA, Spickett CM, Lavender P, Afzali B, Kemper C, Robson MG.
JCI Insight (2017 Jan 26) 2:e87379. Abstract/Full Text
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.
Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.
Science (2016 Jun 17) 352:aad1210. Abstract/Full Text
Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.
Canavan JB, Scottà C, Vossenkämper A, Goldberg R, Elder MJ, Shoval I, Marks E, Stolarczyk E, Lo JW, Powell N, Fazekasova H, Irving PM, Sanderson JD, Howard JK, Yagel S, Afzali B, MacDonald TT, Hernandez-Fuentes MP, Shpigel NY, Lombardi G, Lord GM.
Gut (2016 Apr) 65:584-94. Abstract/Full Text
Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.
Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ.
Elife (2016 Mar 21) 5. Abstract/Full Text
Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells.
Scottà C, Fanelli G, Hoong SJ, Romano M, Lamperti EN, Sukthankar M, Guggino G, Fazekasova H, Ratnasothy K, Becker PD, Afzali B, Lechler RI, Lombardi G.
Haematologica (2016 Jan) 101:91-100. Abstract/Full Text
EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion.
Yang XP, Jiang K, Hirahara K, Vahedi G, Afzali B, Sciume G, Bonelli M, Sun HW, Jankovic D, Kanno Y, Sartorelli V, O'Shea JJ, Laurence A.
Sci Rep (2015 Jun 19) 5:10643. Abstract/Full Text
Regulatory T-cell therapy in the induction of transplant tolerance: the issue of subpopulations.
Edozie FC, Nova-Lamperti EA, Povoleri GA, Scottà C, John S, Lombardi G, Afzali B.
Transplantation (2014 Aug 27) 98:370-9. Abstract/Full Text
Vitamin D in renal transplantation - from biological mechanisms to clinical benefits.
McGregor R, Li G, Penny H, Lombardi G, Afzali B, Goldsmith DJ.
Am J Transplant (2014 Jun) 14:1259-70. Abstract/Full Text
Regulatory T cells in renal cell carcinoma: additional fuel to the bonfire of debate.
Afzali B, Lombardi G.
BJU Int (2013 Sep) 112:538-9. Abstract/Full Text
Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations.
Scottà C, Esposito M, Fazekasova H, Fanelli G, Edozie FC, Ali N, Xiao F, Peakman M, Afzali B, Sagoo P, Lechler RI, Lombardi G.
Haematologica (2013 Aug) 98:1291-9. Abstract/Full Text
Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.
Afzali B, Edozie FC, Fazekasova H, Scottà C, Mitchell PJ, Canavan JB, Kordasti SY, Chana PS, Ellis R, Lord GM, John S, Hilton R, Lechler RI, Lombardi G.
Clin J Am Soc Nephrol (2013 Aug) 8:1396-405. Abstract/Full Text
CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner.
Afzali B, Mitchell PJ, Edozie FC, Povoleri GA, Dowson SE, Demandt L, Walter G, Canavan JB, Scotta C, Menon B, Chana PS, Khamri W, Kordasti SY, Heck S, Grimbacher B, Tree T, Cope AP, Taams LS, Lechler RI, John S, Lombardi G.
Eur J Immunol (2013 Aug) 43:2043-54. Abstract/Full Text