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  5. Laboratory of Molecular Biology
  6. Section on Nuclear Mechanotransduction and Cell Fate Dynamics
We employ interdisciplinary approaches to uncover the role of mechanical forces in regulating chromatin and nuclear architecture and gene expression to modulate stem cell fate.

Select Publications

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.
Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA.
Cell (2020 May 14) 181:800-817.e22. Abstract/Full Text
Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.
Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA.
Nat Cell Biol (2018 Jan) 20:69-80. Abstract/Full Text
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