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NIH: National Institute of Diabetes and Digestive and Kidney Diseases NIH: National Institute of Diabetes and Digestive and Kidney Diseases 75 years: 1950-2025 75 years: 1950-2025
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Bertram J. Canagarajah, Ph.D.

Professional Experience

  • Ph.D., University of Texas Southwestern Medical Center, 1999
  • B.S., University of Texas at Austin, 1994

Research Goal

My research goal is to use cryo-electron microscopy (cryo-EM) to determine the molecular structure of proteins and multi-protein complexes to understand their function.

Select Publications

OPA1 helical structures give perspective to mitochondrial dysfunction.
Nyenhuis SB, Wu X, Strub MP, Yim YI, Stanton AE, Baena V, Syed ZA, Canagarajah B, Hammer JA, Hinshaw JE.
Nature (2023 Aug) 620:1109-1116. Abstract/Full Text
Visualization of Sparsely-populated Lower-order Oligomeric States of Human Mitochondrial Hsp60 by Cryo-electron Microscopy.
Wälti MA, Canagarajah B, Schwieters CD, Clore GM.
J Mol Biol (2021 Dec 3) 433:167322. Abstract/Full Text
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Research in Plain Language

Proteins are complex molecules that play important functions in living organisms. We use cryo-electron microscope to study protein molecules in detail. Knowing the three-dimensional structure of proteins help us to understand their function, and to design drugs to treat diseases that they may be involved in.

Last Reviewed August 2024