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Thomas Eggerman, M.D., Ph.D.

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Cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation

Responsibilities & Activities

I am a scientific officer for the Clinical Islet Transplantation Consortium (CIT), which is comprised of 13 clinical centers and a coordinating center. This consortium is interested in supporting multidisciplinary cellular therapy approaches for controlling blood glucose. Nine protocols have been developed including two pivotal (phase III) studies. Each study has mechanistic studies designed to help understand the responses seen with each intervention. Resources include a central web portal for accessing ongoing study information, patient recruitment facts, specimen availability, process details, and statistics.

I am also the program officer for Cystic Fibrosis grants and Centers programs. The focus is on the non-pulmonary aspects of Cystic Fibrosis.

I am the program director for the Human Islet Research Network (HIRN) Coordinating Center and for the HIRN Bioinformatics Center.

I am the Scientific Officer for the Collaborative Islet Transplantation Registry.

Research Programs

Cystic Fibrosis
Etiology, molecular pathogenesis, pathophysiology, diagnosis, and treatment of cystic fibrosis and its complications.

Cystic Fibrosis Research & Translation Centers
CFRTCs provide support for basic, preclinical, and clinical research efforts to advance scientific knowledge and new therapies for CF.

Endocrine Pancreas
Biology, development, and function of the endocrine pancreas and clinical studies on islet transplantation for type 1 diabetes treatment.

Genetic Metabolic Disease
Basic and clinical studies on the pathophysiology and treatment of inborn errors of metabolism and rare genetic metabolic diseases.

Committees & Working Groups

  • Type 1 Diabetes Working Group, Member
  • Auto-Immunity and Transplantation Working Group, Member
  • HIRN Working Group, Member
  • DEM Clinical Oversight Committee, Member
  • DEM Fellowship Selection Committee, Member
  • Rare Disease Clinical Trials Network, Member