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Cystic Fibrosis Research & Translation Centers

CFRTCs provide support for basic, preclinical, and clinical research efforts to advance scientific knowledge and new therapies for CF.

NIDDK Program Staff

  • Thomas Eggerman, M.D., Ph.D. Cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation

Funding for Cystic Fibrosis Research & Translation Centers

The goal of these CF Research and Translation Centers is to support research to develop and test therapies for CF. Centers provide increased, cost effective collaboration among multidisciplinary groups of investigators at institutions or a group of institutions with an established, comprehensive research base in cystic fibrosis.

NIDDK funds Cystic Fibrosis Centers through a P30 mechanism. Please see the CF Application Resources for required tables and addition documentation.

Centers are funded on the following review schedule:

  • 3 Centers January Council 2018
  • 4 Centers January Council 2020

Resources and Services Available from Cystic Fibrosis Research & Translation Centers

The Cystic Fibrosis Research and Translation Centers provide a variety of research resources to facilitate CF research from basic to the conduct of clinical trials. In addition, there are pilot and feasibility research programs that provide limited funds for early stage investigations.

Cystic Fibrosis Center Sites

The Cystic Fibrosis Research and Translation Centers provide research services for investigators at their sites as well as for other investigators at other regional, national and even international sites. These services are quite varied and include various CF related efforts involving biochemical, cell models, animal models small molecule therapeutic development, gene vectors and clinical applications.

University of North Carolina
  • Research Aims: The UNC focus includes ion transport physiology, mucin biology, microbiology and animal models.
  • Activities & Services: UNC has Cores including preclinical, cell models, mucous biochemistry and clinical translation.
  • Pilot & Feasibility Program
University of Alabama at Birmingham
  • Research Aims: The UAB Center aims are to provide a multi-disciplinary research support for CF basic research and therapy.
  • Activities & Services: The UAB Center maintains Core facilities available for studies of cell biology, ion transport, animal models and translational aspects of CF research.
  • Pilot & Feasibility Program
University of California San Francisco
  • Research Aims: The UCSF focus is to develop novel therapies for cystic fibrosis and to enhance many research projects examining the mechanisms of cystic fibrosis lung disease.
  • Activities & Services: UCSF has Cores including high throughput screening, synthesis, cells and tissues and bioassay.
University of Pittsburgh
  • Research Aims: The U of P focus is to understand the basic mechanisms of CF disease and translate that understanding to provide improved CF treatments.
  • Activities & Services: The U of P has Cores including human airway cells and assays, imaging and translational studies.
  • Pilot & Feasibility Program
University of Washington
  • Research Aims: The U of W focus is clinical-translational science in cystic fibrosis (CF), spanning from early drug development to dissemination into the CF community.
  • Activities & Services: The U of W has Cores including microbiology, genomics, host response and clinical care.
  • Pilot & Feasibility Program
University of Pennsylvania
  • Research Aims: The Penn focus is providing a foundation for basic research necessary to assure the success of gene therapy.
  • Activities & Services: Penn has Cores including vector, immunology and animal models.
  • Pilot & Feasibility Program
University of Iowa
  • Research Aims: The U of Iowa research aims include gene therapy, animal models and CF related diabetes.
  • Activities & Services: The U of Iowa has Cores including gene vector, animal models, clinical, comparative pathology, cells and tissue.
  • Pilot & Feasibility Program

Related Links


Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

  • Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
  • NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
  • NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.

Additional Research Programs

Research Training

Funding Eligibility by Career Level arrow graphic

NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.

Learn about NIDDK Research Training Programs

Diversity

Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.

Learn about NIDDK Diversity Programs

Small Business

Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.

Learn about NIDDK Small Business Programs

Human Subjects Research

Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.

Learn about Human Subjects Research

Translational Research

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NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.

Learn about NIDDK Translational Research Opportunities

Meetings & Events

  • NIH Common Fund

    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.

  • Planning to Apply? Register Early

    Registration is required at eRA Commons and grants.gov and can take 4 weeks.