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Barbara Linder, M.D., Ph.D.

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Type 2 diabetes in children and youth; human studies of metabolic imprinting

Responsibilities & Activities

I am the senior advisor for the Childhood Diabetes Research program. I administer a portfolio of research grants related to several areas, including clinical research focused on 1) type 2 diabetes in youth; and 2) metabolic imprinting. I am the project scientist for the DISCOVERY study, which will recruit and follow a large cohort of youth at risk for type 2 diabetes to better understand the underlying pathophysiology of youth-onset T2D and predict those who are at highest risk. I am also the Project Scientist for the GO MOMs study (Glycemic Observation and Metabolic Outcomes in Mothers and Offspring), which aims to develop better diagnostic approaches for gestational diabetes. My responsibilities also include scientific oversight of the DiCAYA study, led by the U.S. Centers for Disease Control and Prevention and co-funded by NIDDK. This multi-center epidemiological study identifies cases of diabetes in youth and young adults to determine incidence and prevalence of diabetes in these populations. 
In addition to my work at the DEM, I also support the Pediatric Endocrine Clinic at the NIH.

 

Research Programs

Clinical Research in Type 2 Diabetes
Progression and treatment of type 2 diabetes in children and adults.

Diabetes: Treatment, Prevention, & Complications
The Diabetes: Treatment, Prevention, and Complications Program supports both basic and clinical studies aimed at addressing the prevention, treatment and pathophysiology of type 1 and type 2 diabetes across the lifespan.

Obesity, Pregnancy, & the Intrauterine Environment
Impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of mother and offspring.

Pathophysiology of Diabetes & Metabolic Disease
Whole body intermediary carbohydrate, lipid and protein metabolism, energy balance, thermogenesis and mitochondria biology in obesity and diabetes

Last Reviewed April 2024