Diabetes: Treatment, Prevention, & Complications
Basic and clinical studies aimed at addressing the prevention, treatment, and pathophysiology of type 1 and type 2 diabetes.
The Diabetes: Treatment, Prevention, and Complications Program supports both basic and clinical studies aimed at addressing the prevention, treatment and pathophysiology of type 1 and type 2 diabetes. Studies on drug development or testing of medical therapies to treat type 1 and type 2 diabetes are included in this program. Studies specific to type 1 diabetes (T1DM) include those examining the cellular or immunological therapies to induce tolerance or arrest conversion from normal glucose homeostasis or dysglycemia to T1DM. Studies more specific to type 2 diabetes (T2DM) include those examining medical or surgical approaches that prevent diabetes, induce diabetes remission or improve dysglycemia. Studies relevant to both types of diabetes include those proposing lifestyle (diet and exercise) and other behavioral interventions to prevent or treat diabetes, such as approaches to improving health-related behaviors and enhancing diabetes self-management and other aspects of diabetes care. This Program encompasses basic, clinical and translational research on the pathophysiology and treatment of diabetic complications that apply to multiple tissues and organ systems. It includes tissue-specific research on diabetic wound healing, diabetic neuropathy, and central nervous system impairments including cognition, brain structure and function, resulting from dysglycemia. The program also includes research on diabetes complications such as hypoglycemia and diabetic ketoacidosis, as well as studies addressing the impact of metabolic derangements in type 1 and type 2 diabetes mellitus on the skeleton.
NIDDK Program Staff
- Beena Akolkar, Ph.D. Clinical research in the prevention and immunopathogenesis of Type 1 Diabetes and the genetics and genomics of Type 1 and Type 2 Diabetes
- Guillermo A. Arreaza-Rubín, M.D. Diabetes and endocrine disease bioengineering and glucose sensing
- Henry B. Burch, M.D. Clinical studies on the effects of healthy lifestyle and changes on type 2 diabetes, including studies utilizing telemedicine, wearable technology, and mobile applications in the prevention and treatment of type 2 diabetes.
- Barbara Linder, M.D., Ph.D. Type 2 diabetes in children and youth; human studies of metabolic imprinting
- Brad Cooke, Ph.D. Developmental Neuroendocrinology, Electrophysiology, and Cognitive Neuroscience
- Catherine Cowie, Ph.D., M.P.H. Epidemiology of diabetes, including development, control, interventions and complications
- Christine Lee, M.D., M.S. Clinical studies on the development, diagnosis and medical treatment of type 2 diabetes in adults; clinical studies of diabetes in older adults
- Jean M. Lawrence, Sc.D., M.P.H., M.S.S.A. Gestational diabetes; Type 2 diabetes; Application of electronic health records for research; Health systems research; Epidemiology
- Teresa Jones, M.D. Diabetic Foot Consortium, diabetic wound healing, diabetic neuropathy, basic and clinical research of diabetes complications involving multiple organ systems
- Karen L. Teff, Ph.D. Effects of bariatric surgery on diabetes and metabolism, clinical and basic science of hepatic metabolism and hypoglycemia, human sleep and diabetes
- Pamela L. Thornton, Ph.D. Health Equity Research in Type 2 Diabetes; Implementation and Dissemination Science; Natural Experiments; Centers for Diabetes Translation Research
- Saul Malozowski, M.D., Ph.D., M.B.A. Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism; HIV/AIDS-associated metabolic and endocrine dysfunction
Recent Funding OpportunitiesView More Recent Funding Opportunities
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes Biostatistics Research Center (U01 Clinical Trial Not Allowed)
Continuation of The Collaborative Islet Transplantation Registry (U01 Clinical Trial Not Allowed)
Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required)
PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities
Meetings & Workshops
Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.