Obesity, Pregnancy, & the Intrauterine Environment
Impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of mother and offspring.
The Obesity, Pregnancy, and Intrauterine Environment program supports basic and clinical research to understand the impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of both mother and offspring. The program supports observational and interventional clinical studies on the adverse effects of obesity and gestational/type 2 diabetes during pregnancy on mothers and their offspring beyond the immediate neonatal period. NIDDK does not generally support research focusing on the primary prevention or treatment of gestational diabetes directed at the immediate pregnancy outcomes/complications in women or their newborns. Interventional studies may involve, but are not limited to, diet (including food components/dietary supplements), physical activity programs, medications, or bariatric surgery that aim to mitigate or prevent adverse effects of over-nutrition and dysglycemia during and after pregnancy/delivery in both the mothers and their offspring beyond the immediate neonatal period. The program also supports basic and clinical research investigating the mechanisms by which the intrauterine environment alters metabolic responses in offspring. A particular focus is on the role of the pathophysiological consequences of obesity and/or diabetes on the offspring. The long-term goal of this program is to identify molecular targets that could be therapeutically altered in order to prevent or ameliorate the increasing incidence and deleterious effects of obesity and type 2 diabetes.
NIDDK Program Staff
- Barbara Linder, M.D., Ph.D. Type 2 diabetes in children and youth; medical management of type 1 diabetes in children, youth and adults; human studies of metabolic imprinting
- Corinne M. Silva, Ph.D. Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease
- Mary Evans, Ph.D. Multi-center Clinical Studies in Nutrition & Obesity; Nutrition Obesity Research Centers; Diet & Physical Activity Assessment Methodology
- Saul Malozowski, M.D., Ph.D., M.B.A. Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism
Recent Funding OpportunitiesView More Recent Funding Opportunities
Advanced Clinical Trials to test Artificial Pancreas Device Systems in Type 1 Diabetes (U01 Clinical Trial Required)
Mass Spectrometric Assays for the Reliable and Reproducible Detection of Proteins/Peptides of Importance in Obesity Research (U01 Clinical Trial Not Allowed)
Establishing a Cohort to Clarify Risk and Protective Factors for Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) - Planning Cooperative Agreements (U34 Clinical Trial Not Allowed)
Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/44 Clinical Trial Not Allowed)
Type 1 Diabetes TrialNet Clinical Network Hub (U01 Clinical Trial Not Allowed)
View related clinical trials from ClinicalTrials.gov.
Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
- Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
- NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
- NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
Additional Research Programs
NIDDK supports the training and career development of medical and graduate students, postdoctoral fellows, and physician scientists through institutional and individual grants.Learn about NIDDK Research Training Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.Learn about NIDDK Diversity Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs support innovative research conducted by small businesses that has the potential for commercialization.Learn about NIDDK Small Business Programs
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.Learn about Human Subjects Research
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries into novel therapeutics.Learn about NIDDK Translational Research Opportunities