Publications

A selection of recent and significant publications can be viewed below.

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Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1.
Lertdumrongluk P, Streja E, Rhee CM, Moradi H, Chang Y, Reddy U, Tantisattamo E, Kalantar-Zadeh K, Kopp JB.
Cardiorenal Med (2019) 9:212-221. Abstract/Full Text
Open-Label Clinical Trials of Oral Pulse Dexamethasone for Adults with Idiopathic Nephrotic Syndrome.
Cho ME, Branton MH, Smith DA, Bartlett L, Howard L, Reynolds JC, Rosenstein D, Sethi S, Nava MB, Barisoni L, Fervenza FC, Kopp JB.
Am J Nephrol (2019) 49:377-385. Abstract/Full Text
APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.
Ryu JH, Ge M, Merscher S, Rosenberg AZ, Desante M, Roshanravan H, Okamoto K, Shin MK, Hoek M, Fornoni A, Kopp JB.
PLoS One (2019) 14:e0211559. Abstract/Full Text
APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.
Okamoto K, Rausch JW, Wakashin H, Fu Y, Chung JY, Dummer PD, Shin MK, Chandra P, Suzuki K, Shrivastav S, Rosenberg AZ, Hewitt SM, Ray PE, Noiri E, Le Grice SFJ, Hoek M, Han Z, Winkler CA, Kopp JB.
Commun Biol (2018) 1:188. Abstract/Full Text
APOL1 Genotype and Renal Function of Black Living Donors.
Doshi MD, Ortigosa-Goggins M, Garg AX, Li L, Poggio ED, Winkler CA, Kopp JB.
J Am Soc Nephrol (2018 Apr) 29:1309-1316. Abstract/Full Text

Additional Publications

Treatment-resistant PLA2R-negative membranous nephropathy responsive to low-density lipoprotein apheresis.
Szymanski JM, Waldman M, Conry-Cantilena C, West KA.
J Clin Apher (2019 Aug) 34:495-498. Abstract/Full Text
Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus.
Hasni S, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Joyal E, Fike A, Manna Z, Auh S, Shi Y, Chan D, Carlucci P, Biehl A, Dema B, Charles N, Balow JE, Waldman M, Siegel RM, Kaplan MJ, Rivera J.
Arthritis Rheumatol (2019 Jul) 71:1135-1140. Abstract/Full Text
One Actor, Many Roles: Histopathologies Associated With APOL1 Genetic Variants.
Kopp JB, Rosenberg AZ.
Adv Anat Pathol (2019 May) 26:215-219. Abstract/Full Text
Health-related quality of life in glomerular disease.
Canetta PA, Troost JP, Mahoney S, Kogon AJ, Carlozzi N, Bartosh SM, Cai Y, Davis TK, Fernandez H, Fornoni A, Gbadegesin RA, Herreshoff E, Mahan JD, Nachman PH, Selewski DT, Sethna CB, Srivastava T, Tuttle KR, Wang CS, Falk RJ, Gharavi AG, Gillespie BW, Greenbaum LA, Holzman LB, Kretzler M, Robinson BM, Smoyer WE, Guay-Woodford LM, Reeve B, Gipson DS, CureGN Consortium..
Kidney Int (2019 May) 95:1209-1224. Abstract/Full Text
Effects of metreleptin on proteinuria in patients with lipodystrophy.
Lee HL, Waldman MA, Auh S, Balow JE, Cochran EK, Gorden P, Brown RJ.
J Clin Endocrinol Metab (2019 Apr 16) Abstract/Full Text
Autoantibodies are present before the clinical diagnosis of systemic sclerosis.
Burbelo PD, Gordon SM, Waldman M, Edison JD, Little DJ, Stitt RS, Bailey WT, Hughes JB, Olson SW.
PLoS One (2019) 14:e0214202. Abstract/Full Text
CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.
Mariani LH, Bomback AS, Canetta PA, Flessner MF, Helmuth M, Hladunewich MA, Hogan JJ, Kiryluk K, Nachman PH, Nast CC, Rheault MN, Rizk DV, Trachtman H, Wenderfer SE, Bowers C, Hill-Callahan P, Marasa M, Poulton CJ, Revell A, Vento S, Barisoni L, Cattran D, D'Agati V, Jennette JC, Klein JB, Laurin LP, Twombley K, Falk RJ, Gharavi AG, Gillespie BW, Gipson DS, Greenbaum LA, Holzman LB, Kretzler M, Robinson B, Smoyer WE, Guay-Woodford LM, CureGN Consortium..
Am J Kidney Dis (2019 Feb) 73:218-229. Abstract/Full Text
Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option?
Mastellos DC, Reis ES, Biglarnia AR, Waldman M, Quigg RJ, Huber-Lang M, Seelen MA, Daha MR, Lambris JD.
Clin Immunol (2019 Jan) 198:102-105. Abstract/Full Text
Alström syndrome: Renal findings in correlation with obesity, insulin resistance, dyslipidemia and cardiomyopathy in 38 patients prospectively evaluated at the NIH clinical center.
Waldman M, Han JC, Reyes-Capo DP, Bryant J, Carson KA, Turkbey B, Choyke P, Naggert JK, Gahl WA, Marshall JD, Gunay-Aygun M.
Mol Genet Metab (2018 Sep) 125:181-191. Abstract/Full Text
Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women.
Franceschini N, Kopp JB, Barac A, Martin LW, Li Y, Qian H, Reiner AP, Pollak M, Wallace RB, Rosamond WD, Winkler CA.
JAMA Cardiol (2018 Aug 1) 3:712-720. Abstract/Full Text
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.
Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R.
J Clin Invest (2018 Jul 2) 128:3041-3052. Abstract/Full Text
ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2.
Lee H, Roshanravan H, Wang Y, Okamoto K, Ryu J, Shrivastav S, Qu P, Kopp JB.
Am J Physiol Renal Physiol (2018 Jul 1) 315:F140-F150. Abstract/Full Text
Association of Sickle Cell Trait With Ischemic Stroke Among African Americans: A Meta-analysis.
Hyacinth HI, Carty CL, Seals SR, Irvin MR, Naik RP, Burke GL, Zakai NA, Wilson JG, Franceschini N, Winkler CA, David VA, Kopp JB, Judd SE, Adams RJ, Longstreth WT Jr, Egede L, Lackland DT, Taylor H, Manson JE, Howard V, Allison M, Gee BE, Correa A, Safford MM, Arnett DK, Howard G, Reiner AP, Cushman M.
JAMA Neurol (2018 Jul 1) 75:802-807. Abstract/Full Text
APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.
Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA.
Circ Genom Precis Med (2018 Jun) 11:e002098. Abstract/Full Text
Apolipoprotein L1 nephropathies: 2017 in review.
Kopp JB, Roshanravan H, Okamoto K.
Curr Opin Nephrol Hypertens (2018 May) 27:153-158. Abstract/Full Text
APOL1 nephropathy risk variants do not associate with subclinical atherosclerosis or left ventricular mass in middle-aged black adults.
Gutiérrez OM, Limou S, Lin F, Peralta CA, Kramer HJ, Carr JJ, Bibbins-Domingo K, Winkler CA, Lewis CE, Kopp JB.
Kidney Int (2018 Mar) 93:727-732. Abstract/Full Text
Does TSH Reliably Detect Hypothyroid Patients?
Ling C, Sun Q, Khang J, Felipa Lastarria M, Strong J, Stolze B, Yu X, Parikh TP, Waldman MA, Welsh K, Jonklaas J, Masika L, Soldin SJ.
Ann Thyroid Res (2018) 4:122-125. Abstract/Full Text
Renal Fanconi syndrome with meropenem/amoxicillin-clavulanate during treatment of extensively drug-resistant tuberculosis.
Abadie ME, Strich JR, Kim T, Xie YL, Fennelly KP, Olivier KN, Waldman M, Arora K, Holland SM, Chen RY.
Eur Respir J (2017 Dec) 50. Abstract/Full Text
Kidney Diseases Associated with Human Immunodeficiency Virus Infection.
Cohen SD, Kopp JB, Kimmel PL.
N Engl J Med (2017 Dec 14) 377:2363-2374. Abstract/Full Text
APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy.
Kopp JB, Heymann J, Winkler CA.
Semin Nephrol (2017 Nov) 37:514-519. Abstract/Full Text
APOL1 genetic variants are not associated with longitudinal blood pressure in young black adults.
Chen TK, Estrella MM, Vittinghoff E, Lin F, Gutierrez OM, Kramer H, Lewis CE, Kopp JB, Allen NB, Winkler CA, Bibbins-Domingo KB, Peralta CA.
Kidney Int (2017 Oct) 92:964-971. Abstract/Full Text
Chronic Kidney Disease in the Aging Human Immunodeficiency Virus-Infected Population.
Kopp JB.
J Infect Dis (2017 Sep 15) 216:619-621. Abstract/Full Text
APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death.
Hughson MD, Hoy WE, Mott SA, Bertram JF, Winkler CA, Kopp JB.
Kidney Int Rep (2018 Jan) 3:89-98. Abstract/Full Text
A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.
Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J.
Nat Med (2017 Aug) 23:945-953. Abstract/Full Text
Sickle Cell Trait and the Risk of ESRD in Blacks.
Naik RP, Irvin MR, Judd S, Gutiérrez OM, Zakai NA, Derebail VK, Peralta C, Lewis MR, Zhi D, Arnett D, McClellan W, Wilson JG, Reiner AP, Kopp JB, Winkler CA, Cushman M.
J Am Soc Nephrol (2017 Jul) 28:2180-2187. Abstract/Full Text
APOL1-associated glomerular disease among African-American children: a collaboration of the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts.
Ng DK, Robertson CC, Woroniecki RP, Limou S, Gillies CE, Reidy KJ, Winkler CA, Hingorani S, Gibson KL, Hjorten R, Sethna CB, Kopp JB, Moxey-Mims M, Furth SL, Warady BA, Kretzler M, Sedor JR, Kaskel FJ, Sampson MG.
Nephrol Dial Transplant (2017 Jun 1) 32:983-990. Abstract/Full Text
Detection and monitoring PLA2R autoantibodies by LIPS in membranous nephropathy.
Burbelo PD, Beck LH Jr, Waldman M.
J Immunol Methods (2017 May) 444:17-23. Abstract/Full Text
Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.
Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K.
Nat Med (2017 Apr) 23:429-438. Abstract/Full Text
Absence of APOL1 risk alleles in a remote living Australian Aboriginal group with high rates of CKD, hypertension, diabetes, and cardiovascular disease.
Hoy WE, Kopp JB, Mott SA, Winkler CA.
Kidney Int (2017 Apr) 91:990. Abstract/Full Text
A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity.
Carmona-Rivera C, Purmalek MM, Moore E, Waldman M, Walter PJ, Garraffo HM, Phillips KA, Preston KL, Graf J, Kaplan MJ, Grayson PC.
JCI Insight (2017 Feb 9) 2:e89780. Abstract/Full Text
Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte.
Heymann J, Winkler CA, Hoek M, Susztak K, Kopp JB.
Nephrol Dial Transplant (2017 Jan 1) 32:i65-i70. Abstract/Full Text
Renal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis.
Woroniecki RP, Ng DK, Limou S, Winkler CA, Reidy KJ, Mitsnefes M, Sampson MG, Wong CS, Warady BA, Furth SL, Kopp JB, Kaskel FJ.
Front Pediatr (2016) 4:122. Abstract/Full Text
Combined Effects of GSTM1 Null Allele and APOL1 Renal Risk Alleles in CKD Progression in the African American Study of Kidney Disease and Hypertension Trial.
Bodonyi-Kovacs G, Ma JZ, Chang J, Lipkowitz MS, Kopp JB, Winkler CA, Le TH.
J Am Soc Nephrol (2016 Oct) 27:3140-3152. Abstract/Full Text
Brief Report: APOL1 Renal Risk Variants Are Associated With Chronic Kidney Disease in Children and Youth With Perinatal HIV Infection.
Purswani MU, Patel K, Winkler CA, Spector SA, Hazra R, Seage GR 3rd, Mofenson L, Karalius B, Scott GB, Van Dyke RB, Kopp JB, Pediatric HIVAIDS Cohort Study..
J Acquir Immune Defic Syndr (2016 Sep 1) 73:63-8. Abstract/Full Text
Membranous nephropathy: Pilot study of a novel regimen combining cyclosporine and Rituximab.
Waldman M, Beck LH Jr, Braun M, Wilkins K, Balow JE, Austin HA 3rd.
Kidney Int Rep (2016 Jul) 1:73-84. Abstract/Full Text
APOL1 Risk Alleles are Associated with More Severe Arteriosclerosis in Renal Resistance Vessels with Aging and Hypertension.
Hughson MD, Hoy WE, Mott SA, Puelles VG, Bertram JF, Winkler CL, Kopp JB.
Kidney Int Rep (2016 May) 1:10-23. Abstract/Full Text
A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
Yu H, Artomov M, Brähler S, Stander MC, Shamsan G, Sampson MG, White JM, Kretzler M, Miner JH, Jain S, Winkler CA, Mitra RD, Kopp JB, Daly MJ, Shaw AS.
J Clin Invest (2016 Apr 1) 126:1603. Abstract/Full Text
A Clinical Service to Support the Return of Secondary Genomic Findings in Human Research.
Darnell AJ, Austin H, Bluemke DA, Cannon RO 3rd, Fischbeck K, Gahl W, Goldman D, Grady C, Greene MH, Holland SM, Hull SC, Porter FD, Resnik D, Rubinstein WS, Biesecker LG.
Am J Hum Genet (2016 Mar 3) 98:435-441. Abstract/Full Text
Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects.
Sampson MG, Robertson CC, Martini S, Mariani LH, Lemley KV, Gillies CE, Otto EA, Kopp JB, Randolph A, Vega-Warner V, Eichinger F, Nair V, Gipson DS, Cattran DC, Johnstone DB, O'Toole JF, Bagnasco SM, Song PX, Barisoni L, Troost JP, Kretzler M, Sedor JR, Nephrotic Syndrome Study Network..
J Am Soc Nephrol (2016 Mar) 27:814-23. Abstract/Full Text
APOL1 Genotype and Race Differences in Incident Albuminuria and Renal Function Decline.
Peralta CA, Bibbins-Domingo K, Vittinghoff E, Lin F, Fornage M, Kopp JB, Winkler CA.
J Am Soc Nephrol (2016 Mar) 27:887-93. Abstract/Full Text
A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
Yu H, Artomov M, Brähler S, Stander MC, Shamsan G, Sampson MG, White JM, Kretzler M, Miner JH, Jain S, Winkler CA, Mitra RD, Kopp JB, Daly MJ, Shaw AS.
J Clin Invest (2016 Mar 1) 126:1067-78. Abstract/Full Text
Association of APOL1 Genotype with Renal Histology among Black HIV-Positive Patients Undergoing Kidney Biopsy.
Atta MG, Estrella MM, Skorecki KL, Kopp JB, Winkler CA, Wasser WG, Shemer R, Racusen LC, Kuperman M, Foy MC, Lucas GM, Fine DM.
Clin J Am Soc Nephrol (2016 Feb 5) 11:262-70. Abstract/Full Text
APOL1 Risk Alleles Are Associated with Exaggerated Age-Related Changes in Glomerular Number and Volume in African-American Adults: An Autopsy Study.
Hoy WE, Hughson MD, Kopp JB, Mott SA, Bertram JF, Winkler CA.
J Am Soc Nephrol (2015 Dec) 26:3179-89. Abstract/Full Text
APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans.
Kasembeli AN, Duarte R, Ramsay M, Mosiane P, Dickens C, Dix-Peek T, Limou S, Sezgin E, Nelson GW, Fogo AB, Goetsch S, Kopp JB, Winkler CA, Naicker S.
J Am Soc Nephrol (2015 Nov) 26:2882-90. Abstract/Full Text
Sequencing rare and common APOL1 coding variants to determine kidney disease risk.
Limou S, Nelson GW, Lecordier L, An P, O'hUigin CS, David VA, Binns-Roemer EA, Guiblet WM, Oleksyk TK, Pays E, Kopp JB, Winkler CA.
Kidney Int (2015 Oct) 88:754-63. Abstract/Full Text