Genetics of Organelle Biogenesis Section

of the Laboratory of Biochemistry & Genetics

Studying the assembly of centrosomes and centrioles.

Select Publications

The kinase ZYG-1 phosphorylates the cartwheel protein SAS-5 to drive centriole assembly in C. elegans.
Sankaralingam P, Wang S, Liu Y, Oegema KF, O'Connell KF.
EMBO Rep (2024 Jun) 25:2698-2721. Abstract/Full Text
The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number.
Iyer J, Gentry LK, Bergwell M, Smith A, Guagliardo S, Kropp PA, Sankaralingam P, Liu Y, Spooner E, Bowerman B, O'Connell KF.
PLoS Genet (2022 Apr) 18:e1009799. Abstract/Full Text
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Last Reviewed January 2025