My work investigates how nutritional status influences brain chemistry and eating behavior in humans. I use molecular neuroimaging techniques including positron emission tomography and magnetic resonance spectroscopy to better understand how our body weight and the foods and nutrients in our diets can impact the brain to influence how easy or difficult it is to change eating behavior.
My work investigates how manipulating dietary macronutrient composition influences energy balance and metabolic health in humans. We aim to understand the integrated physiology of these responses using a combination of whole-body and mechanistic measures. My current project is investigating how switching to a ketogenic diet impacts sleeping energy expenditure, substrate oxidation, and hepatic metabolism in an inpatient feeding setting. We are also exploring the potential for Nicotinamide Riboside supplementation to augment these effects.
By combining integrative physiology with nutritional sciences, my work investigates how dietary macronutrient manipulation relates to body weight, energy intake, and metabolism in a clinical setting. My current projects seek to determine how differentially manipulating carbohydrates and fat can influence energy intake, body weight regulation, and energy metabolism, in an out-patient translational setting. We are also exploring the implications of how various study design and research methodology considerations can influence these outcomes.