Molecular Signaling Section

of the Laboratory of Bioorganic Chemistry

G protein-coupled receptors and beta-arrestins; Mutant mouse models; Identification of novel targets for the therapy of diabetes and obesity

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Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice.
Kimura T, Pydi SP, Wang L, Haspula D, Cui Y, Lu H, König GM, Kostenis E, Steinberg GR, Gavrilova O, Wess J.
Nat Commun (2022 Mar 29) 13:1652. Abstract/Full Text
Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells.
Meister J, Bone DBJ, Knudsen JR, Barella LF, Velenosi TJ, Akhmedov D, Lee RJ, Cohen AH, Gavrilova O, Cui Y, Karsenty G, Chen M, Weinstein LS, Kleinert M, Berdeaux R, Jensen TE, Richter EA, Wess J.
Nat Commun (2022 Jan 10) 13:22. Abstract/Full Text
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