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NIH: National Institute of Diabetes and Digestive and Kidney Diseases NIH: National Institute of Diabetes and Digestive and Kidney Diseases
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Molecular Signaling Section

of the Laboratory of Bioorganic Chemistry

Dr. Jürgen Wess
G protein-coupled receptors and beta-arrestins; Mutant mouse models; Identification of novel targets for the therapy of diabetes and obesity
About Our Research

Select Publications

Activation of G(12)-type G proteins in pancreatic β cells protects against impaired glucose homeostasis.
Pittala S, Liu L, Haspula D, Cui Y, Fulgenzi G, Inoue A, Wess J.
Sci Adv (2026 Aug 28) 12:eaeh5504. Abstract/Full Text
Altered G(i) signaling in enteroendocrine K cells in vivo causes pronounced changes in glucose homeostasis.
Rivera-Gonzalez O, Liu L, Gribble FM, Reimann F, Wess J.
Sci Adv (2026 Jul 31) 12:eaeb9805. Abstract/Full Text
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Lab Members

Members of the Wess lab smiling and sitting at a long table with plates of food in front of them.

Members of the Molecular Signaling Section

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Research Materials
Last Reviewed September 2026