Research Materials & Patents

1. M1 Muscarinic receptor KO (Chrm1 tm1Jwe) Mouse

   M1 Muscarinic Receptor Knockout: support involvement in cognitive processes.The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to…
   Summary
   PI: Wess, Jurgen

2. M2 Muscarinic receptor KO (Chrm2 tm1Jwe) Mouse

   M2 Muscarinic Receptor Knockout: role in learning and memory, and mediating analgesic effects of muscarinic agonists The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to…
   Summary
   PI: Wess, Jurgen

3. M3 Muscarinic Receptor Knockout mice are hypophagic, lean, & have improved glucose tolerance & insulin sensitivity

   M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to…
   Summary
   PI: Wess, Jurgen

4. M4 Muscarinic receptor KO (Chrm4 tm1Jwe) Mouse

   M4 Muscarinic Receptor Knockout: Activation of M4R may reduce the reinforcing effect of drugs of abuse, and contribute to the analgesic effects observed after administration of muscarinic agonists.The five Muscarinic Acetylcholine (ACh) receptors are…
   Summary
   PI: Wess, Jurgen

5. M5 Muscarinic receptor KO (Chrm5 tm1Jwe) Mouse

   M5 Muscarinic Receptor Knockout: Deficiency of M5Rs reduces drug-seeking behavior.The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively…
   Summary
   PI: Wess, Jurgen