Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly.
Li Q, Pène V, Krishnamurthy S, Cha H, Liang TJ.
Nat Med (2013 Jun) 19:722-9. Abstract/Full Text
Current and future therapies for hepatitis C virus infection.
Liang TJ, Ghany MG.
N Engl J Med (2013 May 16) 368:1907-17. Abstract/Full Text
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ, Liang TJ.
Sci Transl Med (2015 Apr 8) 7:282ra49. Abstract/Full Text
Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.
Cheng X, Uchida T, Xia Y, Umarova R, Liu CJ, Chen PJ, Gaggar A, Suri V, Mücke MM, Vermehren J, Zeuzem S, Teraoka Y, Osawa M, Aikata H, Tsuji K, Mori N, Hige S, Karino Y, Imamura M, Chayama K, Liang TJ.
J Clin Invest (2020 Jun 1) 130:3205-3220. Abstract/Full Text
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1.
Hu Z, Rolt A, Hu X, Ma CD, Le DJ, Park SB, Houghton M, Southall N, Anderson DE, Talley DC, Lloyd JR, Marugan JC, Liang TJ.
Cell Chem Biol (2020 Jul 16) 27:780-792.e5. Abstract/Full Text

Additional Publications

Immunological mechanisms and therapeutic targets of fatty liver diseases.
Wang H, Mehal W, Nagy LE, Rotman Y.
Cell Mol Immunol (2021 Jan) 18:73-91. Abstract/Full Text
Risk Factors for Delta Hepatitis in a North American Cohort: Who Should Be Screened?
Da BL, Rahman F, Lai WC, Kleiner DE, Heller T, Koh C.
Am J Gastroenterol (2021 Jan 1) 116:206-209. Abstract/Full Text
Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity.
Ma Y, Karki S, Brown PM, Lin DD, Podszun MC, Zhou W, Belyaeva OV, Kedishvili NY, Rotman Y.
J Lipid Res (2020 Nov) 61:1400-1409. Abstract/Full Text
Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis.
Podszun MC, Alawad AS, Lingala S, Morris N, Huang WA, Yang S, Schoenfeld M, Rolt A, Ouwerkerk R, Valdez K, Umarova R, Ma Y, Fatima SZ, Lin DD, Mahajan LS, Samala N, Violet PC, Levine M, Shamburek R, Gharib AM, Kleiner DE, Garraffo HM, Cai H, Walter PJ, Rotman Y.
Redox Biol (2020 Oct) 37:101710. Abstract/Full Text
HLA-B*35:01 and Green Tea Induced Liver Injury.
Hoofnagle JH, Bonkovsky HL, Phillips EJ, Li YJ, Ahmad J, Barnhart H, Durazo F, Fontana RJ, Gu J, Khan I, Kleiner DE, Koh C, Rockey DC, Seeff LB, Serrano J, Stolz A, Tillmann HL, Vuppalanchi R, Navarro VJ, Drug-Induced Liver Injury Network..
Hepatology (2020 Sep 5) Abstract/Full Text
Genetic Determinants of Cirrhosis and Hepatocellular Carcinoma Due to Fatty Liver Disease: What's the Score?
Pfeiffer RM, Rotman Y, O'Brien TR.
Hepatology (2020 Sep) 72:794-796. Abstract/Full Text
MR elastography-based liver fibrosis correlates with liver events in nonalcoholic fatty liver patients: A multicenter study.
Han MAT, Vipani A, Noureddin N, Ramirez K, Gornbein J, Saouaf R, Baniesh N, Cummings-John O, Okubote T, Setiawan VW, Rotman Y, Loomba R, Alkhouri N, Noureddin M.
Liver Int (2020 Sep) 40:2242-2251. Abstract/Full Text
Design and in vivo activity of A3 adenosine receptor agonist prodrugs.
Suresh RR, Jain S, Chen Z, Tosh DK, Ma Y, Podszun MC, Rotman Y, Salvemini D, Jacobson KA.
Purinergic Signal (2020 Sep) 16:367-377. Abstract/Full Text
4-HNE Immunohistochemistry and Image Analysis for Detection of Lipid Peroxidation in Human Liver Samples Using Vitamin E Treatment in NAFLD as a Proof of Concept.
Podszun MC, Chung JY, Ylaya K, Kleiner DE, Hewitt SM, Rotman Y.
J Histochem Cytochem (2020 Sep) 68:635-643. Abstract/Full Text
Hsd17b13 Deficiency Does not Protect Mice From Obesogenic Diet Injury.
Ma Y, Brown PM, Lin DD, Ma J, Feng D, Belyaeva OV, Podszun MC, Roszik J, Allen J, Umarova R, Kleiner DE, Kedishvili NY, Gavrilova O, Gao B, Rotman Y.
Hepatology (2020 Aug 11) Abstract/Full Text
Rhythmic Fluctuations in Levels of Liver Enzymes During Menstrual Cycles of Healthy Women and Effects of Body Weight.
Lai CW, Jadhav S, Njei B, Ye A, Wactawski-Wende J, Mumford SL, Schisterman EF, Rotman Y.
Clin Gastroenterol Hepatol (2020 Aug) 18:2055-2063.e2. Abstract/Full Text
A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma.
Liu J, Tang W, Budhu A, Forgues M, Hernandez MO, Candia J, Kim Y, Bowman ED, Ambs S, Zhao Y, Tran B, Wu X, Koh C, Surana P, Liang TJ, Guarnera M, Mann D, Rajaure M, Greten TF, Wang Z, Yu H, Wang XW.
Cell (2020 Jul 23) 182:317-328.e10. Abstract/Full Text
Is SARS-CoV-2 Also an Enteric Pathogen With Potential Fecal-Oral Transmission? A COVID-19 Virological and Clinical Review.
Ding S, Liang TJ.
Gastroenterology (2020 Jul) 159:53-61. Abstract/Full Text
Coronavirus Disease-19 Has Come Home to Roost in Gastroenterology.
Koh C, Liang TJ.
Gastroenterology (2020 Jul) 159:36-38. Abstract/Full Text
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.
O'Mara AE, Johnson JW, Linderman JD, Brychta RJ, McGehee S, Fletcher LA, Fink YA, Kapuria D, Cassimatis TM, Kelsey N, Cero C, Sater ZA, Piccinini F, Baskin AS, Leitner BP, Cai H, Millo CM, Dieckmann W, Walter M, Javitt NB, Rotman Y, Walter PJ, Ader M, Bergman RN, Herscovitch P, Chen KY, Cypess AM.
J Clin Invest (2020 May 1) 130:2209-2219. Abstract/Full Text
Vibration-controlled transient elastography for the detection of cirrhosis in chronic hepatitis D infection.
Da BL, Surana P, Takyar V, Kleiner DE, Heller T, Koh C.
J Viral Hepat (2020 Apr) 27:428-436. Abstract/Full Text
Durability of Spontaneous and Treatment-Related Loss of Hepatitis B s Antigen.
Alawad AS, Auh S, Suarez D, Ghany MG.
Clin Gastroenterol Hepatol (2020 Mar) 18:700-709.e3. Abstract/Full Text
Dietary fatty acid oxidation is decreased in non-alcoholic fatty liver disease: A palmitate breath test study.
Naguib G, Morris N, Yang S, Fryzek N, Haynes-Williams V, Huang WA, Norman-Wheeler J, Rotman Y.
Liver Int (2020 Mar) 40:590-597. Abstract/Full Text
United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.
Oketch-Rabah HA, Roe AL, Rider CV, Bonkovsky HL, Giancaspro GI, Navarro V, Paine MF, Betz JM, Marles RJ, Casper S, Gurley B, Jordan SA, He K, Kapoor MP, Rao TP, Sherker AH, Fontana RJ, Rossi S, Vuppalanchi R, Seeff LB, Stolz A, Ahmad J, Koh C, Serrano J, Low Dog T, Ko R.
Toxicol Rep (2020) 7:386-402. Abstract/Full Text
The Delta-4 fibrosis score (D4FS): A novel fibrosis score in chronic hepatitis D.
Da BL, Surana P, Kleiner DE, Heller T, Koh C.
Antiviral Res (2020 Feb) 174:104691. Abstract/Full Text
Chronic hepatitis delta: A state-of-the-art review and new therapies.
Gilman C, Heller T, Koh C.
World J Gastroenterol (2019 Aug 28) 25:4580-4597. Abstract/Full Text
Longitudinal effects of Nucleos(t)ide analogue therapy in chronic hepatitis B patients and the utility of non-invasive fibrosis markers during treatment: A single-center experience for up to 17 years.
Surana P, Kapuria D, Broadwell C, Wright EC, Takyar V, Kleiner DE, Ghany MG, Ben-Yakov G, Heller T, Liang TJ, Koh C.
Antiviral Res (2019 Aug) 168:61-67. Abstract/Full Text
Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122.
Lowey B, Hertz L, Chiu S, Valdez K, Li Q, Liang TJ.
mBio (2019 Jul 30) 10. Abstract/Full Text
Hepatic Manifestations of Cystic Fibrosis.
Sakiani S, Kleiner DE, Heller T, Koh C.
Clin Liver Dis (2019 May) 23:263-277. Abstract/Full Text
17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease.
Ma Y, Belyaeva OV, Brown PM, Fujita K, Valles K, Karki S, de Boer YS, Koh C, Chen Y, Du X, Handelman SK, Chen V, Speliotes EK, Nestlerode C, Thomas E, Kleiner DE, Zmuda JM, Sanyal AJ, (for the Nonalcoholic Steatohepatitis Clinical Research Network)., Kedishvili NY, Liang TJ, Rotman Y.
Hepatology (2019 Apr) 69:1504-1519. Abstract/Full Text
A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.
Koh C, Dubey P, Han MAT, Walter PJ, Garraffo HM, Surana P, Southall NT, Borochov N, Uprichard SL, Cotler SJ, Etzion O, Heller T, Dahari H, Liang TJ.
Antiviral Res (2019 Mar) 163:149-155. Abstract/Full Text
Rates of and Factors Associated With Placebo Response in Trials of Pharmacotherapies for Nonalcoholic Steatohepatitis: Systematic Review and Meta-analysis.
Han MAT, Altayar O, Hamdeh S, Takyar V, Rotman Y, Etzion O, Lefebvre E, Safadi R, Ratziu V, Prokop LJ, Murad MH, Noureddin M.
Clin Gastroenterol Hepatol (2019 Mar) 17:616-629.e26. Abstract/Full Text
Development of Direct-acting Antiviral and Host-targeting Agents for Treatment of Hepatitis B Virus Infection.
Xia Y, Liang TJ.
Gastroenterology (2019 Jan) 156:311-324. Abstract/Full Text
Pathogenesis of and New Therapies for Hepatitis D.
Koh C, Heller T, Glenn JS.
Gastroenterology (2019 Jan) 156:461-476.e1. Abstract/Full Text
Development of Hepatic Steatosis After Chemotherapy for Non-Hodgkin Lymphoma.
Ben-Yakov G, Alao H, Haydek JP, Fryzek N, Cho MH, Hemmati M, Samala V, Shovlin M, Dunleavy K, Wilson W, Jones EC, Rotman Y.
Hepatol Commun (2019 Feb) 3:220-226. Abstract/Full Text
TM6SF2 Promotes Lipidation and Secretion of Hepatitis C Virus in Infected Hepatocytes.
Boyer A, Park SB, de Boer YS, Li Q, Liang TJ.
Gastroenterology (2018 Dec) 155:1923-1935.e8. Abstract/Full Text
Baseline Intrahepatic and Peripheral Innate Immunity are Associated with Hepatitis C Virus Clearance During Direct-Acting Antiviral Therapy.
Alao H, Cam M, Keembiyehetty C, Zhang F, Serti E, Suarez D, Park H, Fourie NH, Wright EC, Henderson WA, Li Q, Liang TJ, Rehermann B, Ghany MG.
Hepatology (2018 Dec) 68:2078-2088. Abstract/Full Text
Rheological determinants for simultaneous staging of hepatic fibrosis and inflammation in patients with chronic liver disease.
Sinkus R, Lambert S, Abd-Elmoniem KZ, Morse C, Heller T, Guenthner C, Ghanem AM, Holm S, Gharib AM.
NMR Biomed (2018 Oct) 31:e3956. Abstract/Full Text
Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.
Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang TJ.
J Virol (2018 Oct 1) 92. Abstract/Full Text
Starry Night on Liver MRI: An Unexpected Incidental Finding in a Healthy Recruit.
Ben-Yakov G, Kapuria D, Heller T.
Gastroenterology (2018 Sep) 155:621-622. Abstract/Full Text
"Dwarfing" White Strands on Screening Colonoscopy!
Chitsaz E, Rotcheewaphan S, Koh C, Heller T.
Gastroenterology (2018 Sep) 155:e22-e23. Abstract/Full Text
Spleen and Liver Volumetrics as Surrogate Markers of Hepatic Venous Pressure Gradient in Patients With Noncirrhotic Portal Hypertension.
Etzion O, Takyar V, Novack V, Gharib AM, Canales R, Adebogun A, Matsumoto E, Eccleston JL, Kleiner DE, Rosenzweig SD, Gunay-Aygun M, Uzel G, Fuss I, Childs R, Holland SM, Levy EB, Liang TJ, Heller T, Koh C.
Hepatol Commun (2018 Aug) 2:919-928. Abstract/Full Text
Association of Hepatic Steatosis With Subclinical Atherosclerosis: Systematic Review and Meta-Analysis.
Kapuria D, Takyar VK, Etzion O, Surana P, O'Keefe JH, Koh C.
Hepatol Commun (2018 Aug) 2:873-883. Abstract/Full Text
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.
Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R.
J Clin Invest (2018 Jul 2) 128:3041-3052. Abstract/Full Text
Social media: Why AASLD and its members must lead the conversation.
Heller T, Koh C, Kumar S.
Hepatology (2018 Jul) 68:4-6. Abstract/Full Text
Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
Rolt A, Le D, Hu Z, Wang AQ, Shah P, Singleton M, Hughes E, Dulcey AE, He S, Imamura M, Uchida T, Chayama K, Xu X, Marugan JJ, Liang TJ.
J Infect Dis (2018 May 5) 217:1761-1769. Abstract/Full Text
Noncirrhotic portal hypertension.
Da BL, Koh C, Heller T.
Curr Opin Gastroenterol (2018 May) 34:140-145. Abstract/Full Text
Liver disease in patients with cystic fibrosis.
Kamal N, Surana P, Koh C.
Curr Opin Gastroenterol (2018 May) 34:146-151. Abstract/Full Text
The Changing Paradigm of Management of Liver Abscesses in Chronic Granulomatous Disease.
Straughan DM, McLoughlin KC, Mullinax JE, Marciano BE, Freeman AF, Anderson VL, Uzel G, Azoury SC, Sorber R, Quadri HS, Malech HL, DeRavin SS, Kamal N, Koh C, Zerbe CS, Kuhns DB, Gallin JI, Heller T, Holland SM, Rudloff U.
Clin Infect Dis (2018 Apr 17) 66:1427-1434. Abstract/Full Text
Optimizing lonafarnib treatment for the management of chronic delta hepatitis: The LOWR HDV-1 study.
Yurdaydin C, Keskin O, Kalkan Ç, Karakaya F, Çalişkan A, Karatayli E, Karatayli S, Bozdayi AM, Koh C, Heller T, Idilman R, Glenn JS.
Hepatology (2018 Apr) 67:1224-1236. Abstract/Full Text