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Barbara Linder, M.D., Ph.D.

Photo of Dr. Barbara Linder
Type 2 diabetes in children and youth; medical management of type 1 diabetes in children, youth and adults; human studies of metabolic imprinting

Responsibilities & Activities

I am the senior advisor for the Childhood Diabetes Research program. I administer a portfolio of research grants related to the care of individuals with type 1 diabetes and youth with type 2 diabetes, as well as a portfolio of clinical research grants related to metabolic imprinting. I am the project scientist for the TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) follow-up study. TODAY compared three different treatments for type 2 diabetes in youth, and demonstrated that type 2 diabetes is a particularly aggressive disease when it occurs at a young age. My responsibilities also include scientific oversight of the SEARCH study, co-led by the NIDDK and the U.S. Centers for Disease Control and Prevention. This multicenter epidemiological study identifies cases of diabetes in people younger than age 20 in five geographically dispersed populations that reflect the ethnic diversity of the United States. SEARCH reports on incidence, prevalence, and clinical course of diabetes in U.S. youth. In addition, I help oversee the cooperative agreement grants for the Diabetes Prevention Program Outcomes study, the Glycemic Reduction Approaches in Diabetes Effectiveness study, Restoring Insulin Secretion Consortium, and the Hyperglycemia and Adverse Pregnancy Outcomes study.

In addition to my work at the DEM, I also support the Pediatric Endocrine Clinic at the NIH.

Research Programs

Clinical Research in Type 1 Diabetes
Determinants, etiology, progression, prevention, and treatment of type 1 diabetes in children and adults.

Clinical Research in Type 2 Diabetes
Progression and treatment of type 2 diabetes in children and adults.

Obesity, Pregnancy, & the Intrauterine Environment
Impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of mother and offspring.

Pathophysiology of Diabetes & Metabolic Disease
Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.