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Barbara Linder, M.D., Ph.D.

Photo of Barbara Linder
Type 2 diabetes in children and youth; human studies of metabolic imprinting

Responsibilities & Activities

I am the senior advisor for the Childhood Diabetes Research program. I administer a portfolio of research grants related to several areas, including clinical research focused on 1) type 2 diabetes in youth; and 2) metabolic imprinting. I am the project scientist for the TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) follow-up study. TODAY compared three different treatments for type 2 diabetes in youth and demonstrated that type 2 diabetes is a particularly aggressive disease when it occurs at a young age. My responsibilities also include scientific oversight of the DiCAYA study, led by the U.S. Centers for Disease Control and Prevention and co-funded by NIDDK. This multi-center epidemiological study identifies cases of diabetes in youth and young adults to determine incidence and prevalence of diabetes in these populations. I am also the Project Scientist for the GO MOMs study (Glycemic Observation and Metabolic Outcomes in Mothers and Offspring), which aims to develop better diagnostic approaches for gestational diabetes. In addition, I help oversee the cooperative agreement awards for DPPOS (Diabetes Prevention Program Outcomes Study), GRADE (Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study), and ARMMS (Alliance of Randomized Trials of Medicine v. Metabolic Surgery in Type 2 Diabetes).

In addition to my work at the DEM, I also support the Pediatric Endocrine Clinic at the NIH.

Research Programs

Clinical Research in Type 1 Diabetes
Determinants, etiology, progression, prevention, and treatment of type 1 diabetes in children and adults.

Clinical Research in Type 2 Diabetes
Progression and treatment of type 2 diabetes in children and adults.

Diabetes: Treatment, Prevention, & Complications
Basic and clinical studies aimed at addressing the prevention, treatment, and pathophysiology of type 1 and type 2 diabetes.

Obesity, Pregnancy, & the Intrauterine Environment
Impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of mother and offspring.

Pathophysiology of Diabetes & Metabolic Disease
Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.