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Barbara Linder, M.D., Ph.D.

Photo of Barbara Linder
Type 2 diabetes in children and youth; human studies of metabolic imprinting

Responsibilities & Activities

I am the senior advisor for the Childhood Diabetes Research program. I administer a portfolio of research grants related to several areas, including clinical research focused on: 1) the care of individuals with type 1 diabetes; 2) type 2 diabetes in youth; 3) the relationship between gestational diabetes and subsequent T2D in women; and 4) metabolic imprinting. I am the project scientist for the TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) follow-up study. TODAY compared three different treatments for type 2 diabetes in youth and demonstrated that type 2 diabetes is a particularly aggressive disease when it occurs at a young age. My responsibilities also include scientific oversight of the SEARCH study, co-led by the NIDDK and the U.S. Centers for Disease Control and Prevention. This multi-center epidemiological study identifies cases of diabetes in people younger than age 20 in five geographically dispersed populations that reflect the ethnic diversity of the United States. SEARCH reports on incidence, prevalence, and clinical course of diabetes in U.S. youth. I am also  the Project Scientist for the Glycemic Profile in Pregnancy Consortium. In addition, I help oversee the cooperative agreement awards for DPPOS (Diabetes Prevention Program Outcomes Study), GRADE (Glycemic Reduction Approaches in Diabetes:A Comparative Effectiveness Study), RISE (Restoring Insulin Secretion Consortium), and ARMMS (Alliance of Randomized Trials of Medicine v. Metabolic Surgery in Type 2 Diabetes).

In addition to my work at the DEM, I also support the Pediatric Endocrine Clinic at the NIH.

Research Programs

Clinical Research in Type 1 Diabetes
Determinants, etiology, progression, prevention, and treatment of type 1 diabetes in children and adults.

Clinical Research in Type 2 Diabetes
Progression and treatment of type 2 diabetes in children and adults.

Diabetes: Treatment, Prevention, & Complications
Basic and clinical studies aimed at addressing the prevention, treatment, and pathophysiology of type 1 and type 2 diabetes.

Obesity, Pregnancy, & the Intrauterine Environment
Impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of mother and offspring.

Pathophysiology of Diabetes & Metabolic Disease
Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes.