Treatment for Primary Sclerosing Cholangitis

In this section:

How do doctors treat PSC?

Currently, no cure or effective treatments for primary sclerosing cholangitis (PSC) exist. However, doctors can treat narrowed or blocked bile ducts and symptoms of PSC.

Narrowed or blocked bile ducts

If bile ducts are narrowed or blocked, doctors may use endoscopic retrograde cholangiopancreatography (ERCP) to open them and help keep them open. To help keep ducts open, doctors sometimes place stents. Stents are tiny tubes that a doctor leaves in narrowed ducts for a short time to hold them open.

In some cases, doctors may use percutaneous transhepatic cholangiography to open narrowed or blocked bile ducts.

Itchy skin

Doctors may recommend over-the-counter medicines or prescribe medicines to treat itchy skin caused by PSC.

How do doctors treat the complications of PSC?

Liver complications

Doctors may recommend treatments for liver complications of PSC.

Cirrhosis or portal hypertension

If PSC leads to cirrhosis or portal hypertension, doctors can treat the health problems related to these conditions with medicines, medical procedures, or surgery.

Liver failure

If cirrhosis leads to liver failure, you may need a liver transplant.


PSC increases the risk for developing several types of cancer. Your doctor may recommend tests to check for signs of cancer. Finding cancer at an early stage improves the chance of curing the cancer.

Bile duct infection

To treat a bile duct infection, doctors may prescribe antibiotics. To help prevent bile duct infections, doctors may prescribe antibiotics for people with PSC before and after they have procedures, such as ERCP, that increase the risk of getting an infection.

Other complications

Doctors may treat other complications of PSC with medicines, dietary supplements, or changes in diet or lifestyle.

  • For low levels of vitamins A, D, E, and K, doctors may recommend taking dietary supplements of these fat-soluble vitamins. Follow your doctor’s instructions on the type and amount of vitamins you should take.
  • For osteoporosis, doctors may prescribe medicines that slow or stop bone loss and improve bone density. Doctors may recommend taking dietary supplements of calcium and vitamin D.

When do doctors consider a liver transplant for PSC?

Doctors may consider a liver transplant if PSC leads to liver failure or causes severe symptoms or complications. In some patients with bile duct cancer, liver transplant may be the best treatment. Doctors consider liver transplants only after all other treatment options have failed. Talk with your doctor to find out whether a liver transplant is right for you.

Doctor talking with an older patient who is lying in a hospital bed.Doctors may consider a liver transplant if PSC leads to liver failure.

What can I do to prevent further liver damage?

If you have PSC, you can take steps to help prevent further liver damage.

  • Follow your doctor’s instructions carefully and take medicines and dietary supplements as directed.
  • Quit smoking.
  • Do not use illegal drugs.
  • Stop drinking alcohol or, at least, limit your intake. If you have PSC and cirrhosis, completely stop drinking alcohol.
  • Have regular checkups, as recommended by your doctor.
  • Talk with your doctor before taking
  • Try to reach and stay at a healthy body weight.
Last Reviewed February 2022
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This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. NIDDK translates and disseminates research findings to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by NIDDK is carefully reviewed by NIDDK scientists and other experts.