Research Materials & Patents

Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.

  1. Asah2 KO Mouse

    Also known as: Asah2tm1Rlp, neutral ceramidase KO mouse

    Asah2 KO mice lack expression of neutral ceramidase, which is highly expressed in the intestinal epithelia. Asah2 KO mice are viable and grossly normal, lack expression of neutral ceramidase and…

  2. Floxed Ormdl3 Mouse

    Also known as: B6.Cg-Ormdl3tm1.1Rlp/J
     
    ORMDL proteins (ORMDL1, 2 and 3) are a family of small transmembrane endoplasmic reticulum proteins involved in feedback inhibition of the de novo synthesis pathway of sphingolipids by inhibiting serine…
  3. Floxed S1pr1 Mouse

    Also known as: S1pr1tm2.1Rlp, floxed S1P1 mouse

    S1pr1 is a member of the sphingosine-1-phosphate G-protein coupled receptor family. S1pr1 is essential for vascular maturation during embryonic development and is involved in in the regulation of innate…

  4. Floxed Sptlc1 Mouse

    Also known as: Sptlc1tm1.1Rlp

    The Sptlc1tm1.1Rlp  allele  has loxp sites flanking exons 4 and 5.  When the Cre gene is expressed under the control of the Adipoq promotor, the Sptlc1 expression and sphingolipid levels is reduced in…

  5. Floxed Ugcg Mouse

    Also known as: Ugcgtm4Rlp, floxed glucosylceramide synthase mouse, floxed GlcT mouse

    Ugcgtm4Rlp allele has  loxp sites in intron 6 and in the 3’ untranslated region.  Cre expression would be predicted to delete exons 6,7,8 and 9.  Cre…

  6. GalNAcT KO Mouse

    Also known as: B4galnt1tm1Rlp, GM2/GD2 synthase KO mouse

    B4galnt1 KO mice lack complex gangliosides and instead express high levels of simple gangliosides GM3 and GD3. The KO mice display decreased central myelination, axonal degeneration in both the…

  7. GbaL444P Knock-in Mouse

    Also known as: Gbatm1Rlp, Type 3 Gaucher disease mouse

    Gaucher disease, the most common lysosomal storage disease, is caused by mutations in the gene encoding the lysosomal enzyme, glucocerebrosidase encoded by the Gba gene. The L444P mutation in GBA…

  8. GD3 Synthase KO Mouse

    Also known as: St8sia1tm1Rlp, GD3S KO mouse

    GD3 synthase (GD3S), encoded by St8sia1, is a sialyltransferase expressed in the nervous system, that is responsible for the synthesis of b-series gangliosides. St8sia1 KO mice, even with an absence of…

  9. GM2 Activator Deficiency Disease Mouse

    Also known as: Gm2atm1Rlp , Gm2a KO mouse, AB Variant of GM2 gangliosidosis mouse

    Gm2a KO mice demonstrate neuronal storage of GM2 ganglioside in restricted regions of the brain (piriform, entorhinal cortex, amygdala, and hypothalmic nuclei…

  10. GM3 Synthase KO Mouse

    Also known as: St3gal5tm1Rlp, St3gal5 KO mouse

    The St3gal5 KO mice are viable and appear grossly normal but show a heightened sensitivity to insulin. A basis for the increased insulin sensitivity in the mutant mice is enhanced insulin receptor…

  11. Inducible SPT Mouse

    Also known as: Floxed stop fusion-serine palmitoyl transferase mouse, Stop-fSPT mouse, B6J.FVB-Gt(ROSA)26Sortm3(CAG-SPTLC2/SPTSSA/SPTLC1,-EGFP)1Rlp/Mmucd
     
    The mice carry a transgene that is a single-chain version of serine…
  12. OrmdI1 KO Mouse

    Also known as: C57BL/6-Ormdl1em1Rlp/J
     
    ORMDL proteins (ORMDL1, 2 and 3) are a family of small transmembrane endoplasmic reticulum proteins involved in feedback inhibition of the de novo synthesis pathway of sphingolipids by inhibiting serine…
  13. Ormdl2 KO Mouse

    Also known as: C57BL/6-Ormdl2em1Rlp/J
     
    ORMDL proteins (ORMDL1, 2 and 3) are a family of small transmembrane endoplasmic reticulum proteins involved in feedback inhibition of the de novo synthesis pathway of sphingolipids by inhibiting serine…
  14. S1P1 GFP Signaling Mouse

    Also known as: S1pr1tm3.1(tTA,-Arrb2)Rlp, S1P1 Tango mouse

    These S1pr1 knockin mice have a bicistronic transcription unit inserted at the C-terminus of exon 2 of the sphingosine-1-phosphate receptor 1 (S1pr1) gene. Specifically, the allele contains…

  15. S1P1 Luciferase Signaling Mouse

    S1P1 luciferase signaling mice enable the bioluminescent detection of sphingosine-1-phosphate receptor 1 (S1P1) activation in real time. A synthetic S1P1 signaling pathway, designed to report the interaction between S1P1and β-arrestin2 via the…

  16. S1pr1 KO Mouse

    Also known as: S1pr1tm1Rlp, sphingosine-1-phosphate receptor 1 KO mouse, S1P1 KO mouse, Edg1 KO mouse

    S1pr1 is a member of the sphingosine-1-phosphate G-protein coupled receptor family. S1pr1 is essential for vascular maturation during embryonic…

  17. S1pr2 KO Mouse

    Also known as: S1pr2tm1Rlp, sphingosine-1-phosphate receptor 2 KO mouse, S1P2 KO mouse, Edg5 KO mouse

    S1pr2 is a member of the sphingosine-1-phosphate G-protein coupled receptor family. S1pr2 KO mice exhibit deafness, seizures and are prone…

  18. S1pr3 KO Mouse

    Also known as: S1pr3tm1Rlp, sphingosine-1-phosphate receptor 3 KO mouse, S1P3 KO mouse, Edg3 KO mouse

    S1pr3 is a member of the sphingosine-1-phosphate G-protein coupled receptor family. S1pr3 KO mice are grossly normal. Double KO S1pr2/S1pr3 mice…

  19. Sandhoff Disease Mouse

    Also known as: Hexbtm1Rlp, Hexb KO mouse

    Hexb KO mice develop motor defects beginning at about 3 months of age. The defects progressively worsen and homozygous mice die by 4.5 months of age. Mice display gangliosidosis; mice abnormally accumulate GM2…

  20. Sgpp2 KO Mouse

    Also known as: Sgpp2tm1Rlp, sphingosine-1-phosphate (S1P) phosphatase 2 KO mouse

    Intracellular metabolism of sphingosine-1-phosphate (S1P) is controlled, in part, by two homologous S1P phosphatases (SPPases), 1 and 2, which are encoded by the Sgpp1

  21. Sphk1 KO Mouse

    Also known as: Sphk1tm1Rlp, sphingosine kinase 1 KO mouse

    Sphingosine kinase 1 and 2, expressed by the Sphk1 and Sphk2 genes, respectively, are enzymes that catalyzes the synthesis of sphingosine-1-phosphate (S1P), a lipid signaling molecule, from…

  22. Sphk2 KO Mouse

    Also known as: Sphk2tm1Rlp, sphingosine kinase 2 KO mouse

    Sphingosine kinase 1 and 2, expressed by the Sphk1 and Sphk2 genes, respectively, are enzymes that catalyzes the synthesis of sphingosine-1-phosphate (S1P), a lipid signaling molecule, from…

  23. Tay-Sachs Disease Mouse

    Also known as: Hexatm1Rlp, Hexa KO mouse

    These Hexa knock-out mice exhibit accumulation of GM2 ganglioside in the central nervous system. They are suitable for use in applications related to the study of Tay-Sachs disease in humans. Learn more on