Using chemistry to discover new pharmacological tool compounds and translational candidate molecules, to investigate the role of purinergic signaling in health and disease.

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Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y(14) Receptor Antagonists.
Wen Z, Pramanik A, Lewicki SA, Jung YH, Gao ZG, Randle JCR, Cronin C, Chen Z, Giancotti LA, Whitehead GS, Liang BT, Breton S, Salvemini D, Cook DN, Jacobson KA.
J Med Chem (2023 Jul 13) 66:9076-9094. Abstract/Full Text
A(3) adenosine receptor agonists containing dopamine moieties for enhanced interspecies affinity.
Tosh DK, Salmaso V, Campbell RG, Rao H, Bitant A, Pottie E, Stove CP, Liu N, Gavrilova O, Gao ZG, Auchampach JA, Jacobson KA.
Eur J Med Chem (2022 Jan 15) 228:113983. Abstract/Full Text
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Last Reviewed February 2023