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NIH: National Institute of Diabetes and Digestive and Kidney Diseases NIH: National Institute of Diabetes and Digestive and Kidney Diseases 75 years: 1950-2025 75 years: 1950-2025
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  6. Molecular Recognition Section

Molecular Recognition Section

of the Laboratory of Bioorganic Chemistry

Kenneth Jacobson. Kenneth A. Jacobson, Ph.D., John W. Daly Distinguished Scientist

Section Chief

kennethj@nih.gov
Using chemistry to discover new pharmacological tool compounds and translational candidate molecules, to investigate the role of purinergic signaling in health and disease.
About Our Research

Select Publications

Structure of the human dopamine transporter and mechanisms of inhibition.
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E.
Nature (2024 Aug) 632:672-677. Abstract/Full Text
Lipid Trolling to Optimize A(3) Adenosine Receptor-Positive Allosteric Modulators (PAMs).
Pradhan B, Pavan M, Fisher CL, Salmaso V, Wan TC, Keyes RF, Rollison N, Suresh RR, Kumar TS, Gao ZG, Smith BC, Auchampach JA, Jacobson KA.
J Med Chem (2024 Jul 25) 67:12221-12247. Abstract/Full Text
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Lab Members

Staff of the Molecular Recognition Section

Staff of the Molecular Recognition Section

View Our Lab Members
Research Materials
Last Reviewed February 2025