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  6. Molecular Recognition Section

Molecular Recognition Section

of the Laboratory of Bioorganic Chemistry

Photo of Kenneth Jacobson. Kenneth A. Jacobson, Ph.D., John W. Daly Distinguished Scientist

Section Chief

kennethj@nih.gov
Using chemistry to discover new pharmacological tool compounds and translational candidate molecules, to investigate the role of purinergic signaling in health and disease.
About Our Research

Select Publications

Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y(14)R Antagonist.
Wen Z, Salmaso V, Jung YH, Phung NB, Gopinatth V, Shah Q, Patterson AT, Randle JCR, Chen Z, Salvemini D, Lieberman DI, Whitehead GS, Karcz TP, Cook DN, Jacobson KA.
J Med Chem (2022 Feb 24) 65:3434-3459. Abstract/Full Text
Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.
Scortichini M, Idris RM, Moschütz S, Keim A, Salmaso V, Dobelmann C, Oliva P, Losenkova K, Irjala H, Vaittinen S, Sandholm J, Yegutkin GG, Sträter N, Junker A, Müller CE, Jacobson KA.
J Med Chem (2022 Feb 10) 65:2409-2433. Abstract/Full Text
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Lab Members

Staff of the Molecular Recognition Section

Staff of the Molecular Recognition Section

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Research Materials