U.S. Department of Health and Human Services
  1. Home
  2. Research and Funding
  3. Research at NIDDK
  4. Labs & Branches
  5. Laboratory of Bioorganic Chemistry
  6. Molecular Recognition Section

Molecular Recognition Section

of the Laboratory of Bioorganic Chemistry

Photo of Kenneth Jacobson. Kenneth A. Jacobson, Ph.D., John W. Daly Distinguished Scientist

Section Chief

kenneth.jacobson2@nih.gov
Using chemistry to discover new pharmacological tool compounds and translational candidate molecules, to investigate the role of purinergic signaling in health and disease.
About Our Research

Select Publications

Structure-Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres.
Jung YH, Salmaso V, Wen Z, Bennett JM, Phung NB, Lieberman DI, Gopinatth V, Randle JCR, Chen Z, Salvemini D, Karcz TP, Cook DN, Jacobson KA.
J Med Chem (2021 Apr 22) 64:5099-5122. Abstract/Full Text
Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.
Scortichini M, Idris RM, Moschütz S, Keim A, Salmaso V, Dobelmann C, Oliva P, Losenkova K, Irjala H, Vaittinen S, Sandholm J, Yegutkin GG, Sträter N, Junker A, Müller CE, Jacobson KA.
J Med Chem (2022 Feb 10) 65:2409-2433. Abstract/Full Text
View More Publications

Lab Members

Staff of the Molecular Recognition Section

Staff of the Molecular Recognition Section

View Our Lab Members
Research Materials