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  6. Molecular Recognition Section

Molecular Recognition Section

of the Laboratory of Bioorganic Chemistry

Photo of Kenneth Jacobson. Kenneth A. Jacobson, Ph.D., John W. Daly Distinguished Scientist

Section Chief

kennethj@niddk.nih.gov
Using chemistry to discover new pharmacological tool compounds and translational candidate molecules, to investigate the role of purinergic signaling in health and disease.
About Our Research

Select Publications

Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core.
Jung YH, Yu J, Wen Z, Salmaso V, Karcz TP, Phung NB, Chen Z, Duca S, Bennett JM, Dudas S, Salvemini D, Gao ZG, Cook DN, Jacobson KA.
J Med Chem (2020 Sep 10) 63:9563-9589. Abstract/Full Text
Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.
Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA.
J Med Chem (2019 Apr 11) 62:3677-3695. Abstract/Full Text
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Lab Members

Staff of the Molecular Recognition Section

Staff of the Molecular Recognition Section

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Research Materials