Structural Cell Biology Section

of the Laboratory of Cell and Molecular Biology

Our goal is to determine the mechanistic properties of dynamin superfamily proteins (DSPs) through cryo-EM analysis and correlate them with their diverse cellular functions.

Select Publications

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, Ditlev JA, Zhang G, Rosen MK, Frost A, Alto NM, Gardel M, Schmid SL, Svitkina TM, Hinshaw JE, Chen EH.
Nat Cell Biol (2020 Jun) 22:674-688. Abstract/Full Text
Cryo-EM of the dynamin polymer assembled on lipid membrane.
Kong L, Sochacki KA, Wang H, Fang S, Canagarajah B, Kehr AD, Rice WJ, Strub MP, Taraska JW, Hinshaw JE.
Nature (2018 Aug) 560:258-262. Abstract/Full Text
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