We are investigating embryonic functions of microRNAs and mechanisms of microRNA turnover.

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Catalytic residues of microRNA Argonautes play a modest role in microRNA star strand destabilization in C. elegans.
Kotagama K, Grimme AL, Braviner L, Yang B, Sakhawala RM, Yu G, Benner LK, Joshua-Tor L, McJunkin K.
Nucleic Acids Res (2024 May 22) 52:4985-5001. Abstract/Full Text
The developmentally timed decay of an essential microRNA family is seed-sequence dependent.
Donnelly BF, Yang B, Grimme AL, Vieux KF, Liu CY, Zhou L, McJunkin K.
Cell Rep (2022 Aug 9) 40:111154. Abstract/Full Text
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Last Reviewed April 2024