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Section on Regulatory RNAs

Publications

A selection of recent and significant publications can be viewed below.

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In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans.
Yang B, Schwartz M, McJunkin K.
Genes Dev (2020 Sep 1) 34:1227-1238. Abstract/Full Text
The mir-35 Family Links Maternal Germline Sex to Embryonic Viability in Caenorhabditis elegans.
Benner LK, Prothro KP, McJunkin K.
G3 (Bethesda) (2019 Mar 7) 9:901-909. Abstract/Full Text
CRISPR screening strategies for microRNA target identification.
Yang B, McJunkin K.
FEBS J (2020 Jul) 287:2914-2922. Abstract/Full Text
Maternal effects of microRNAs in early embryogenesis.
McJunkin K.
RNA Biol (2018 Feb 1) 15:165-169. Abstract/Full Text

Additional Publications

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans.
Davis GM, Tu S, Anderson JW, Colson RN, Gunzburg MJ, Francisco MA, Ray D, Shrubsole SP, Sobotka JA, Seroussi U, Lao RX, Maity T, Wu MZ, McJunkin K, Morris QD, Hughes TR, Wilce JA, Claycomb JM, Weng Z, Boag PR.
Elife (2018 Dec 21) 7. Abstract/Full Text
A microRNA family exerts maternal control on sex determination in C. elegans.
McJunkin K, Ambros V.
Genes Dev (2017 Feb 15) 31:422-437. Abstract/Full Text
miRNAs cooperate in apoptosis regulation during C. elegans development.
Sherrard R, Luehr S, Holzkamp H, McJunkin K, Memar N, Conradt B.
Genes Dev (2017 Jan 15) 31:209-222. Abstract/Full Text
GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.
Jannot G, Michaud P, Quévillon Huberdeau M, Morel-Berryman L, Brackbill JA, Piquet S, McJunkin K, Nakanishi K, Simard MJ.
PLoS Genet (2016 Dec) 12:e1006484. Abstract/Full Text
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.
Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S, Zender L.
Nat Med (2014 Oct) 20:1138-46. Abstract/Full Text
The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans.
McJunkin K, Ambros V.
G3 (Bethesda) (2014 Jul 21) 4:1747-54. Abstract/Full Text
A pipeline for the generation of shRNA transgenic mice.
Dow LE, Premsrirut PK, Zuber J, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW.
Nat Protoc (2012 Feb 2) 7:374-93. Abstract/Full Text
Reversible suppression of an essential gene in adult mice using transgenic RNA interference.
McJunkin K, Mazurek A, Premsrirut PK, Zuber J, Dow LE, Simon J, Stillman B, Lowe SW.
Proc Natl Acad Sci U S A (2011 Apr 26) 108:7113-8. Abstract/Full Text
Functional identification of optimized RNAi triggers using a massively parallel sensor assay.
Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW.
Mol Cell (2011 Mar 18) 41:733-46. Abstract/Full Text
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.
Zuber J, McJunkin K, Fellmann C, Dow LE, Taylor MJ, Hannon GJ, Lowe SW.
Nat Biotechnol (2011 Jan) 29:79-83. Abstract/Full Text
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia.
Mavrakis KJ, Wolfe AL, Oricchio E, Palomero T, de Keersmaecker K, McJunkin K, Zuber J, James T, Khan AA, Leslie CS, Parker JS, Paddison PJ, Tam W, Ferrando A, Wendel HG.
Nat Cell Biol (2010 Apr) 12:372-9. Abstract/Full Text
miR-221 overexpression contributes to liver tumorigenesis.
Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A.
Proc Natl Acad Sci U S A (2010 Jan 5) 107:264-9. Abstract/Full Text
Tissue-specific and reversible RNA interference in transgenic mice.
Dickins RA, McJunkin K, Hernando E, Premsrirut PK, Krizhanovsky V, Burgess DJ, Kim SY, Cordon-Cardo C, Zender L, Hannon GJ, Lowe SW.
Nat Genet (2007 Jul) 39:914-21. Abstract/Full Text