A selection of recent and significant publications can be viewed below.

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Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity.
Hild B, Dreier MS, Oh JH, McCulloch JA, Badger JH, Guo J, Thefaine CE, Umarova R, Hall KD, Gavrilova O, Rosshart SP, Trinchieri G, Rehermann B.
Nat Metab (2021 Aug) 3:1042-1057. Abstract/Full Text
Laboratory mice born to wild mice have natural microbiota and model human immune responses.
Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, McCulloch JA, Anastasakis DG, Sarshad AA, Leonardi I, Collins N, Blatter JA, Han SJ, Tamoutounour S, Potapova S, Foster St Claire MB, Yuan W, Sen SK, Dreier MS, Hild B, Hafner M, Wang D, Iliev ID, Belkaid Y, Trinchieri G, Rehermann B.
Science (2019 Aug 2) 365. Abstract/Full Text
Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection.
Nishio A, Bolte FJ, Takeda K, Park N, Yu ZX, Park H, Valdez K, Ghany MG, Rehermann B.
Sci Transl Med (2021 Mar 31) 13. Abstract/Full Text
Liver-Resident Bystander CD8+ T Cells Contribute to Liver Disease Pathogenesis in Chronic Hepatitis D Virus Infection.
Kefalakes H, Horgan XJ, Jung MK, Amanakis G, Kapuria D, Bolte FJ, Kleiner DE, Koh C, Heller T, Rehermann B.
Gastroenterology (2021 Jul 21) Abstract/Full Text
Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation.
Bolte FJ, O'Keefe AC, Webb LM, Serti E, Rivera E, Liang TJ, Ghany M, Rehermann B.
Gastroenterology (2017 Nov) 153:1392-1403.e2. Abstract/Full Text

Additional Publications

Baseline Intrahepatic and Peripheral Innate Immunity are Associated with Hepatitis C Virus Clearance During Direct-Acting Antiviral Therapy.
Alao H, Cam M, Keembiyehetty C, Zhang F, Serti E, Suarez D, Park H, Fourie NH, Wright EC, Henderson WA, Li Q, Liang TJ, Rehermann B, Ghany MG.
Hepatology (2018 Dec) 68:2078-2088. Abstract/Full Text
The role of genetics in hepatic fibrosis among hepatitis C virus patients.
Park H, O'Brien TR, Rehermann B.
Hepatology (2018 May) 67:2043-2045. Abstract/Full Text
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.
Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y.
Cell (2018 Feb 8) 172:784-796.e18. Abstract/Full Text
Mucosal-Associated Invariant T Cells in Chronic Inflammatory Liver Disease.
Bolte FJ, Rehermann B.
Semin Liver Dis (2018 Feb) 38:60-65. Abstract/Full Text
Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.
Cheng X, Xia Y, Serti E, Block PD, Chung M, Chayama K, Rehermann B, Liang TJ.
Hepatology (2017 Dec) 66:1779-1793. Abstract/Full Text
Tissue-resident T cells in hepatitis B: A new target for cure?
Bolte FJ, Rehermann B.
J Exp Med (2017 Jun 5) 214:1564-1566. Abstract/Full Text
Use of Current and New Endpoints in the Evaluation of Experimental Hepatitis B Therapeutics.
Block TM, Locarnini S, McMahon BJ, Rehermann B, Peters MG.
Clin Infect Dis (2017 May 1) 64:1283-1288. Abstract/Full Text
Rapid decrease in hepatitis C viremia by direct acting antivirals improves the natural killer cell response to IFNα.
Serti E, Park H, Keane M, O'Keefe AC, Rivera E, Liang TJ, Ghany M, Rehermann B.
Gut (2017 Apr) 66:724-735. Abstract/Full Text
Mature peritoneal macrophages take an avascular route into the injured liver and promote tissue repair.
Rehermann B.
Hepatology (2017 Jan) 65:376-379. Abstract/Full Text
Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes.
Kugler DG, Flomerfelt FA, Costa DL, Laky K, Kamenyeva O, Mittelstadt PR, Gress RE, Rosshart SP, Rehermann B, Ashwell JD, Sher A, Jankovic D.
J Exp Med (2016 Dec 12) 213:3041-3056. Abstract/Full Text
Peptide-dependent HLA-KIR-mediated regulation of NK cell function.
Rehermann B.
J Hepatol (2016 Aug) 65:237-9. Abstract/Full Text
HCV in 2015: Advances in hepatitis C research and treatment.
Rehermann B.
Nat Rev Gastroenterol Hepatol (2016 Feb) 13:70-2. Abstract/Full Text
Natural Killer Cells in Viral Hepatitis.
Rehermann B.
Cell Mol Gastroenterol Hepatol (2015 Nov) 1:578-588. Abstract/Full Text
Durability of antibody response against hepatitis B virus in healthcare workers vaccinated as adults.
Gara N, Abdalla A, Rivera E, Zhao X, Werner JM, Liang TJ, Hoofnagle JH, Rehermann B, Ghany MG.
Clin Infect Dis (2015 Feb 15) 60:505-13. Abstract/Full Text
T cell responses in hepatitis C virus infection: historical overview and goals for future research.
Holz L, Rehermann B.
Antiviral Res (2015 Feb) 114:96-105. Abstract/Full Text
Ribavirin improves the IFN-γ response of natural killer cells to IFN-based therapy of hepatitis C virus infection.
Werner JM, Serti E, Chepa-Lotrea X, Stoltzfus J, Ahlenstiel G, Noureddin M, Feld JJ, Liang TJ, Rotman Y, Rehermann B.
Hepatology (2014 Oct) 60:1160-9. Abstract/Full Text
Trace amounts of sporadically reappearing HCV RNA can cause infection.
Veerapu NS, Park SH, Tully DC, Allen TM, Rehermann B.
J Clin Invest (2014 Aug) 124:3469-78. Abstract/Full Text
Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8+ T cell effector functions.
Kang W, Sung PS, Park SH, Yoon S, Chang DY, Kim S, Han KH, Kim JK, Rehermann B, Chwae YJ, Shin EC.
Gastroenterology (2014 May) 146:1351-60.e1-4. Abstract/Full Text
Sequence analysis of hepatitis C virus from patients with relapse after a sustained virological response: relapse or reinfection?
Hara K, Rivera MM, Koh C, Demino M, Page S, Nagabhyru PR, Rehermann B, Liang TJ, Hoofnagle JH, Heller T.
J Infect Dis (2014 Jan 1) 209:38-45. Abstract/Full Text
The hepatitis B vaccine protects re-exposed health care workers, but does not provide sterilizing immunity.
Werner JM, Abdalla A, Gara N, Ghany MG, Rehermann B.
Gastroenterology (2013 Nov) 145:1026-34. Abstract/Full Text
Occupational exposure to hepatitis C virus: early T-cell responses in the absence of seroconversion in a longitudinal cohort study.
Heller T, Werner JM, Rahman F, Mizukoshi E, Sobao Y, Gordon AM, Sheets A, Sherker AH, Kessler E, Bean KS, Herrine SK, Stevens M, Schmitt J, Rehermann B.
J Infect Dis (2013 Sep) 208:1020-5. Abstract/Full Text
Reply: b-cell frequency in HCV-related mixed cryoglobulinemia.
Holz LE, Yoon JC, Raghuraman S, Moir S, Sneller MC, Rehermann B.
Hepatology (2013 Jul) 58:448-9. Abstract/Full Text
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells.
Rehermann B.
Nat Med (2013 Jul) 19:859-68. Abstract/Full Text
The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection.
Shin EC, Park SH, Nascimbeni M, Major M, Caggiari L, de Re V, Feinstone SM, Rice CM, Rehermann B.
J Virol (2013 Apr) 87:4772-7. Abstract/Full Text
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.
Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR.
Nat Genet (2013 Feb) 45:164-71. Abstract/Full Text
IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection.
Park H, Serti E, Eke O, Muchmore B, Prokunina-Olsson L, Capone S, Folgori A, Rehermann B.
Hepatology (2012 Dec) 56:2060-70. Abstract/Full Text
B cell homeostasis in chronic hepatitis C virus-related mixed cryoglobulinemia is maintained through naïve B cell apoptosis.
Holz LE, Yoon JC, Raghuraman S, Moir S, Sneller MC, Rehermann B.
Hepatology (2012 Nov) 56:1602-10. Abstract/Full Text
Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus.
Park SH, Shin EC, Capone S, Caggiari L, De Re V, Nicosia A, Folgori A, Rehermann B.
Gastroenterology (2012 Oct) 143:1048-60.e4. Abstract/Full Text
The clinical relevance of persistent recombinant immunoblot assay-indeterminate reactions: insights into the natural history of hepatitis C virus infection and implications for donor counseling.
Makuria AT, Raghuraman S, Burbelo PD, Cantilena CC, Allison RD, Gibble J, Rehermann B, Alter HJ.
Transfusion (2012 Sep) 52:1940-8. Abstract/Full Text
Infectivity in chimpanzees (Pan troglodytes) of plasma collected before HCV RNA detectability by FDA-licensed assays: implications for transfusion safety and HCV infection outcomes.
Busch MP, Murthy KK, Kleinman SH, Hirschkorn DF, Herring BL, Delwart EL, Racanelli V, Yoon JC, Rehermann B, Alter HJ.
Blood (2012 Jun 28) 119:6326-34. Abstract/Full Text
Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients.
Edlich B, Ahlenstiel G, Zabaleta Azpiroz A, Stoltzfus J, Noureddin M, Serti E, Feld JJ, Liang TJ, Rotman Y, Rehermann B.
Hepatology (2012 Jan) 55:39-48. Abstract/Full Text
Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C.
Ahlenstiel G, Edlich B, Hogdal LJ, Rotman Y, Noureddin M, Feld JJ, Holz LE, Titerence RH, Liang TJ, Rehermann B.
Gastroenterology (2011 Oct) 141:1231-9, 1239.e1-2. Abstract/Full Text
Induction of CXCR3- and CCR5-associated chemokines during acute hepatitis C virus infection.
Zeremski M, Hooker G, Shu MA, Winkelstein E, Brown Q, Des Jarlais DC, Tobler LH, Rehermann B, Busch MP, Edlin BR, Talal AH.
J Hepatol (2011 Sep) 55:545-553. Abstract/Full Text
Delayed induction, not impaired recruitment, of specific CD8⁺ T cells causes the late onset of acute hepatitis C.
Shin EC, Park SH, Demino M, Nascimbeni M, Mihalik K, Major M, Veerapu NS, Heller T, Feinstone SM, Rice CM, Rehermann B.
Gastroenterology (2011 Aug) 141:686-95, 695.e1. Abstract/Full Text
Sporadic reappearance of minute amounts of hepatitis C virus RNA after successful therapy stimulates cellular immune responses.
Veerapu NS, Raghuraman S, Liang TJ, Heller T, Rehermann B.
Gastroenterology (2011 Feb) 140:676-685.e1. Abstract/Full Text
Dendritic cells transfected with Her2 antigen-encoding RNA replicons cross-prime CD8 T cells and protect mice against tumor challenge.
Edlich B, Hogdal LJ, Rehermann B, Behrens SE.
Vaccine (2010 Nov 16) 28:7764-73. Abstract/Full Text
Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner.
Ahlenstiel G, Titerence RH, Koh C, Edlich B, Feld JJ, Rotman Y, Ghany MG, Hoofnagle JH, Liang TJ, Heller T, Rehermann B.
Gastroenterology (2010 Jan) 138:325-35.e1-2. Abstract/Full Text
Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis.
Mix H, Weiler-Normann C, Thimme R, Ahlenstiel G, Shin EC, Herkel J, David CS, Lohse AW, Rehermann B.
Gastroenterology (2008 Dec) 135:2107-18. Abstract/Full Text
Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV.
Mizukoshi E, Eisenbach C, Edlin BR, Newton KP, Raghuraman S, Weiler-Normann C, Tobler LH, Busch MP, Carrington M, McKeating JA, O'Brien TR, Rehermann B.
J Infect Dis (2008 Jul 15) 198:203-12. Abstract/Full Text